{"id":"https://openalex.org/W1982583288","doi":"https://doi.org/10.1073/pnas.0705396104","title":"Innovation and robustness in complex regulatory gene networks","display_name":"Innovation and robustness in complex regulatory gene networks","publication_year":2007,"publication_date":"2007-08-09","ids":{"openalex":"https://openalex.org/W1982583288","doi":"https://doi.org/10.1073/pnas.0705396104","mag":"1982583288","pmid":"https://pubmed.ncbi.nlm.nih.gov/17690244","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1959426"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0705396104","doi":"https://doi.org/10.1073/pnas.0705396104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705396104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1959426","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077209091","display_name":"Stefano Ciliberti","orcid":"https://orcid.org/0000-0001-7833-9547","observed_orcids":["https://orcid.org/0000-0001-7833-9547"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210097733","display_name":"Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques","ror":"https://ror.org/00w67e447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210097733"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Ciliberti","raw_affiliation_strings":["*Unit\u00e9 Mixte Recherche 8565, Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques, Universit\u00e9 Paris-Sud and Centre National de la Recherche Scientifique, F-91405 Orsay, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Unit\u00e9 Mixte Recherche 8565, Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques, Universit\u00e9 Paris-Sud and Centre National de la Recherche Scientifique, F-91405 Orsay, France;","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210097733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005002059","display_name":"Olivier Martin","orcid":"https://orcid.org/0000-0002-5295-5963","observed_orcids":["https://orcid.org/0000-0002-5295-5963"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210097733","display_name":"Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques","ror":"https://ror.org/00w67e447","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210097733"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. C. Martin","raw_affiliation_strings":["*Unit\u00e9 Mixte Recherche 8565, Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques, Universit\u00e9 Paris-Sud and Centre National de la Recherche Scientifique, F-91405 Orsay, France;","Unit\u00e9 Mixte de Recherche 820, Laboratoire de G\u00e9n\u00e9tique V\u00e9g\u00e9tale, L'Institut National de la Recherche Agronomique, Ferme du Moulon, F-91190 Gif-sur-Yvette, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Unit\u00e9 Mixte Recherche 8565, Laboratoire de Physique Th\u00e9orique et Mod\u00e8les Statistiques, Universit\u00e9 Paris-Sud and Centre National de la Recherche Scientifique, F-91405 Orsay, France;","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210097733"]},{"raw_affiliation_string":"Unit\u00e9 Mixte de Recherche 820, Laboratoire de G\u00e9n\u00e9tique V\u00e9g\u00e9tale, L'Institut National de la Recherche Agronomique, Ferme du Moulon, F-91190 Gif-sur-Yvette, France; and","institution_ids":["https://openalex.org/I4387154544"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840","observed_orcids":["https://orcid.org/0000-0003-4299-3840"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"A. Wagner","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Y27-J-54, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Y27-J-54, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.424,"has_fulltext":false,"cited_by_count":356,"citation_normalized_percentile":{"value":0.98597888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"104","issue":"34","first_page":"13591","last_page":"13596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.27219998836517334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy of Biology and Scientific Explanation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolutionary-novelty","display_name":"evolutionary innovation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gene-expression-patterns","display_name":"gene expression patterns","score":0.9309999942779541},{"id":"https://openalex.org/keywords/genotype-space","display_name":"genotype space","score":0.6660000085830688},{"id":"https://openalex.org/keywords/genotype-phenotype-map","display_name":"genotype-phenotype mapping","score":0.6919999718666077},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.8379999995231628},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.671999990940094},{"id":"https://openalex.org/keywords/evolutionary-search","display_name":"evolutionary search","score":0.5559999942779541},{"id":"https://openalex.org/keywords/connected-graphs","display_name":"connected graphs","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7813469171524048},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6130576133728027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6067781448364258},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6019274592399597},{"id":"https://openalex.org/C2778154381","wikidata":"https://www.wikidata.org/wiki/Q105296908","display_name":"Ingenuity","level":2,"score":0.5826255679130554},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5473650693893433},{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.4931041896343231},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4641363024711609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46328869462013245},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4619925320148468},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4480859339237213},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.11274644732475281},{"id":"https://openalex.org/C133425853","wikidata":"https://www.wikidata.org/wiki/Q60571","display_name":"Neoclassical economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0705396104","doi":"https://doi.org/10.1073/pnas.0705396104","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0705396104","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1959426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1959426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:17690244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17690244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1959426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1959426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4515191329","display_name":"Characterization of a large protein interaction network","funder_award_id":"R01GM063882","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W234963275","https://openalex.org/W1487920553","https://openalex.org/W1493846400","https://openalex.org/W1623155147","https://openalex.org/W1627254997","https://openalex.org/W1637936532","https://openalex.org/W1865748464","https://openalex.org/W1965857389","https://openalex.org/W1968814137","https://openalex.org/W1971013467","https://openalex.org/W1977940795","https://openalex.org/W1987229243","https://openalex.org/W1991138583","https://openalex.org/W1999944340","https://openalex.org/W2000163865","https://openalex.org/W2005862991","https://openalex.org/W2010317419","https://openalex.org/W2010579377","https://openalex.org/W2014208555","https://openalex.org/W2022730625","https://openalex.org/W2034536549","https://openalex.org/W2036338631","https://openalex.org/W2038836884","https://openalex.org/W2041042514","https://openalex.org/W2044856354","https://openalex.org/W2046289407","https://openalex.org/W2046585679","https://openalex.org/W2056760934","https://openalex.org/W2060915805","https://openalex.org/W2066440682","https://openalex.org/W2076180442","https://openalex.org/W2076963640","https://openalex.org/W2078236617","https://openalex.org/W2083034544","https://openalex.org/W2090393235","https://openalex.org/W2091817414","https://openalex.org/W2102216585","https://openalex.org/W2111857816","https://openalex.org/W2117357818","https://openalex.org/W2121105996","https://openalex.org/W2126074998","https://openalex.org/W2146536564","https://openalex.org/W2153904514","https://openalex.org/W2154327289","https://openalex.org/W2165330496","https://openalex.org/W2165641442","https://openalex.org/W2493048666","https://openalex.org/W4241088457","https://openalex.org/W4299328967"],"related_works":["https://openalex.org/W4367312628","https://openalex.org/W141572739","https://openalex.org/W2504565007","https://openalex.org/W2134763495","https://openalex.org/W7097135066","https://openalex.org/W2083034544","https://openalex.org/W7099238067","https://openalex.org/W1973081915","https://openalex.org/W2035410644","https://openalex.org/W3188948613"],"abstract_inverted_index":{"The":[0],"history":[1],"of":[2,11,30,66,76,150,186],"life":[3],"involves":[4],"countless":[5],"evolutionary":[6,43,119,145],"innovations,":[7],"a":[8,54,73,77,81,85,96,156],"steady":[9],"stream":[10],"ingenuity":[12],"that":[13,33,61,117,127,173],"has":[14],"been":[15],"flowing":[16],"for":[17,42,56],"more":[18],"than":[19],"3":[20],"billion":[21],"years.":[22],"Very":[23],"little":[24],"is":[25],"known":[26],"about":[27],"the":[28,57,64,92,168,184,187],"principles":[29,41],"biological":[31],"organization":[32],"allow":[34],"such":[35],"innovation.":[36],"Here,":[37],"we":[38,52,171],"examine":[39],"these":[40],"innovation":[44,151,166,175],"in":[45,99,141,167,176,183],"gene":[46,87,177],"expression":[47,88,178],"patterns.":[48],"To":[49],"this":[50,122],"end,":[51],"study":[53],"model":[55],"transcriptional":[58],"regulation":[59],"networks":[60,104],"are":[62,105,128],"at":[63,139],"heart":[65],"embryonic":[67],"development.":[68],"A":[69],"genotype":[70,100,142,192],"corresponds":[71,83],"to":[72,84,147,155,162],"regulatory":[74,113],"network":[75],"given":[78],"topology,":[79],"and":[80],"phenotype":[82,94],"steady-state":[86],"pattern.":[89],"Networks":[90],"with":[91],"same":[93],"form":[95],"connected":[97,191],"graph":[98,123],"space,":[101,143],"where":[102],"two":[103],"immediate":[106],"neighbors":[107],"if":[108,135],"they":[109,136],"differ":[110],"by":[111,190],"one":[112],"interaction.":[114],"We":[115],"show":[116],"an":[118],"search":[120],"on":[121],"can":[124,180],"reach":[125],"genotypes":[126],"as":[129,134],"different":[130,148],"from":[131],"each":[132],"other":[133],"were":[137],"chosen":[138],"random":[140],"allowing":[144],"access":[146],"kinds":[149],"while":[152],"staying":[153],"close":[154],"viable":[157],"phenotype.":[158],"Thus,":[159],"although":[160],"robustness":[161,188],"mutations":[163],"may":[164],"hinder":[165],"short":[169],"term,":[170],"conclude":[172],"long-term":[174],"patterns":[179],"only":[181],"emerge":[182],"presence":[185],"caused":[189],"graphs.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}