{"id":"https://openalex.org/W1982523926","doi":null,"title":"Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study.","display_name":"Cytochrome P450 aromatase expression in canine nervous tissue: an immunohistochemical study.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1982523926","mag":"1982523926","pmid":"https://pubmed.ncbi.nlm.nih.gov/19227133"},"language":"en","primary_location":{"id":"pmid:19227133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19227133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of veterinary sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067307402","display_name":"Siyami Karahan","orcid":"https://orcid.org/0000-0002-2744-1717","observed_orcids":["https://orcid.org/0000-0002-2744-1717"]},"institutions":[{"id":"https://openalex.org/I45642913","display_name":"K\u0131r\u0131kkale University","ror":"https://ror.org/01zhwwf82","country_code":"TR","type":"education","lineage":["https://openalex.org/I45642913"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S Karahan","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Veterinary Medicine, Kirikkale University 71450, Yahsihan, Kirikkale, Turkey. siyamikarahan@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Veterinary Medicine, Kirikkale University 71450, Yahsihan, Kirikkale, Turkey. siyamikarahan@yahoo.com","institution_ids":["https://openalex.org/I45642913"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055443033","display_name":"Murat Yar\u0131m","orcid":"https://orcid.org/0000-0002-0636-4214","observed_orcids":["https://orcid.org/0000-0002-0636-4214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yarim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054315923","display_name":"Nobuhiro Harada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Harada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"4","first_page":"347","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450-aromatase","display_name":"cytochrome P450 aromatase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/canine-brain","display_name":"canine brain","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.8629999756813049},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":1.0},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mitral-cells","display_name":"mitral cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.7792520523071289},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.757767915725708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6395149230957031},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.5889694690704346},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5539386868476868},{"id":"https://openalex.org/C2909073510","wikidata":"https://www.wikidata.org/wiki/Q1134467","display_name":"Ependymal Cell","level":3,"score":0.48944106698036194},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4286598563194275},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3482711911201477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3157864809036255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11676815152168274},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001141","descriptor_name":"Aromatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19227133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19227133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of veterinary sciences","raw_type":"Journal Article"},{"id":"mag:1982523926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19227133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1783731643","https://openalex.org/W1964704545","https://openalex.org/W1971257654","https://openalex.org/W1975759742","https://openalex.org/W1977641315","https://openalex.org/W1978417400","https://openalex.org/W1979931442","https://openalex.org/W1980032554","https://openalex.org/W1983190649","https://openalex.org/W1988134724","https://openalex.org/W2000592915","https://openalex.org/W2007151209","https://openalex.org/W2010667807","https://openalex.org/W2010913652","https://openalex.org/W2021404668","https://openalex.org/W2022159983","https://openalex.org/W2029226337","https://openalex.org/W2029818973","https://openalex.org/W2065203398","https://openalex.org/W2070127617","https://openalex.org/W2075228423","https://openalex.org/W2075990267","https://openalex.org/W2077465916","https://openalex.org/W2077613782","https://openalex.org/W2078147213","https://openalex.org/W2086529841","https://openalex.org/W2086722367","https://openalex.org/W2089892151","https://openalex.org/W2092338494","https://openalex.org/W2100701110","https://openalex.org/W2101458043","https://openalex.org/W2111945524","https://openalex.org/W2136406425","https://openalex.org/W2145865543","https://openalex.org/W2156965301","https://openalex.org/W2317222735"],"related_works":["https://openalex.org/W4291016502","https://openalex.org/W1998778654","https://openalex.org/W1965542848","https://openalex.org/W1969309241","https://openalex.org/W2004542686","https://openalex.org/W2064750807","https://openalex.org/W2152141678","https://openalex.org/W310290516","https://openalex.org/W2080035201","https://openalex.org/W2395846073"],"abstract_inverted_index":{"The":[0,21,164,190],"enzyme":[1],"cytochrome":[2],"P450":[3],"aromatase":[4,28,170,193],"is":[5],"responsible":[6,211],"for":[7,212],"conversion":[8],"of":[9,27,43,68,74,129,138,152,166,192],"androgens":[10],"to":[11,94,159],"estrogens.":[12],"Estrogens":[13],"have":[14],"been":[15],"implicated":[16],"in":[17,30,52,54,64,70,113,127,135,149,161,172,182,187,194,215],"neurophysiology":[18],"and":[19,34,40,57,116,134,141,156,176,185,200],"neuropathology.":[20],"present":[22,63,126,148],"study":[23],"investigated":[24],"the":[25,31,44,55,71,75,78,105,122,130,139,153,162,188,216],"presence":[26,165,191],"immunoreactivity":[29,48,124,171],"temporal,":[32],"parietal":[33],"occipital":[35],"cortices,":[36],"olfactory":[37,58,106],"bulb,":[38,107],"cerebellum,":[39,123],"choroid":[41,201],"plexus":[42],"normal":[45],"dog.":[46,189],"Aromatase":[47],"was":[49,61,125,146],"localized":[50],"exclusively":[51],"neurons":[53,101,109,128,137],"cortices":[56],"bulb.":[59],"Immunoreactivity":[60,145],"also":[62,147],"a":[65],"small":[66],"number":[67],"astrocytes":[69],"substantia":[72],"alba":[73],"cerebellum.":[76],"In":[77,104,121],"cortical":[79],"regions,":[80],"immunoreactive":[81,108],"neurons,":[82,173],"morphologically":[83],"identified":[84],"as":[85],"pyramidal":[86,100],"cells,":[87],"were":[88,102,110],"found":[89],"throughout":[90],"Layer":[91,95],"II":[92],"down":[93],"VI,":[96],"but":[97],"not":[98],"all":[99],"immunoreactive.":[103],"mainly":[111],"observed":[112],"mitral":[114],"cells":[115,151,178,196,203,207],"inner":[117],"granular":[118,142],"cell":[119,143],"layers.":[120,144],"deep":[131],"cerebellar":[132],"nuclei":[133],"some":[136,174],"molecular":[140],"endothelial":[150,177],"subarachnoid":[154],"vessels":[155],"those":[157],"adjacent":[158],"ventricles":[160,199],"cortex.":[163],"well":[167],"defined":[168],"cytoplasmic":[169],"astrocytes,":[175],"suggests":[179,204],"estrogen":[180,213],"involvement":[181],"CNS":[183],"physiology":[184],"function":[186],"ependymal":[195],"lining":[197],"cerebral":[198],"epithelial":[202],"that":[205],"these":[206],"may":[208],"be":[209],"partially":[210],"concentration":[214],"cerebrospinal":[217],"fluid.":[218]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}