{"id":"https://openalex.org/W1982296353","doi":"https://doi.org/10.1074/jbc.m110.159517","title":"Structural Studies and the Assembly of the Heptameric Post-translational Translocon Complex","display_name":"Structural Studies and the Assembly of the Heptameric Post-translational Translocon Complex","publication_year":2010,"publication_date":"2010-09-09","ids":{"openalex":"https://openalex.org/W1982296353","doi":"https://doi.org/10.1074/jbc.m110.159517","mag":"1982296353","pmid":"https://pubmed.ncbi.nlm.nih.gov/20826819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3024790"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.159517","doi":"https://doi.org/10.1074/jbc.m110.159517","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.159517","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110.159517","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014312307","display_name":"Yoichiro Harada","orcid":"https://orcid.org/0000-0003-1818-9633","observed_orcids":["https://orcid.org/0000-0003-1818-9633"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoichiro Harada","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA","From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115601958","display_name":"Hua Long Li","orcid":"https://orcid.org/0000-0002-8786-4295","observed_orcids":["https://orcid.org/0000-0002-8786-4295"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":["From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113568516","display_name":"Joseph S. Wall","orcid":"https://orcid.org/0000-0002-9552-6368","observed_orcids":["https://orcid.org/0000-0002-9552-6368"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Wall","raw_affiliation_strings":["the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330148","display_name":"Huilin Li","orcid":"https://orcid.org/0000-0001-8085-8928","observed_orcids":["https://orcid.org/0000-0001-8085-8928"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huilin Li","raw_affiliation_strings":["From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"the Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071234506","display_name":"William J. Lennarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William J. Lennarz","raw_affiliation_strings":["From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 and","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071234506"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.139,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.72651489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"286","issue":"4","first_page":"2956","last_page":"2965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.7738999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sec61-channel","display_name":"Sec61 channel","score":0.7649999856948853},{"id":"https://openalex.org/keywords/complex-assembly","display_name":"complex assembly","score":0.6230000257492065},{"id":"https://openalex.org/keywords/positively-charged-residues","display_name":"positively charged residues","score":0.6200000047683716},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C199229279","wikidata":"https://www.wikidata.org/wiki/Q610647","display_name":"Translocon","level":4,"score":0.9838007688522339},{"id":"https://openalex.org/C113584667","wikidata":"https://www.wikidata.org/wiki/Q16946673","display_name":"Sec61","level":5,"score":0.7728055715560913},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5985965728759766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3942631483078003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3749111592769623},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36864984035491943},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.34614861011505127},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3296138048171997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3072062134742737},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.22910407185554504},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13957256078720093}],"mesh":[{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020836","descriptor_name":"Protein Structure, Quaternary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m110.159517","doi":"https://doi.org/10.1074/jbc.m110.159517","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.159517","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2271606","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3024790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3024790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3024790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20826819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20826819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.159517","doi":"https://doi.org/10.1074/jbc.m110.159517","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.159517","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G186543472","display_name":"Enzymatic Conversion of Proteins to Glycoproteins","funder_award_id":"R01GM033185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2977500713","display_name":"ENZYMATIC CONVERSION OF PROTEINS TO GLYCOPROTEINS","funder_award_id":"R37GM033185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3083709880","display_name":"The Structural Basis of Eukaryotic Replication Origin Licensing by Cryo-EM","funder_award_id":"R01GM074985","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G380065250","display_name":null,"funder_award_id":"GM-33185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891972","display_name":"Molecular mechanisms of protein glycosylation and trafficking","funder_award_id":"R01CA231466","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W27345972","https://openalex.org/W1966072209","https://openalex.org/W1968636401","https://openalex.org/W1973463353","https://openalex.org/W1979260907","https://openalex.org/W1981124257","https://openalex.org/W1994742864","https://openalex.org/W1995223052","https://openalex.org/W1998092533","https://openalex.org/W1998564815","https://openalex.org/W2002863315","https://openalex.org/W2009168935","https://openalex.org/W2021878227","https://openalex.org/W2026542719","https://openalex.org/W2040036884","https://openalex.org/W2056431625","https://openalex.org/W2062634373","https://openalex.org/W2068119233","https://openalex.org/W2071748696","https://openalex.org/W2073726493","https://openalex.org/W2077333037","https://openalex.org/W2087069728","https://openalex.org/W2100455255","https://openalex.org/W2103330224","https://openalex.org/W2103778190","https://openalex.org/W2109184486","https://openalex.org/W2112382738","https://openalex.org/W2118278390","https://openalex.org/W2122550753","https://openalex.org/W2127324121","https://openalex.org/W2131581447","https://openalex.org/W2132629607","https://openalex.org/W2154786726","https://openalex.org/W2155234325","https://openalex.org/W2155489806","https://openalex.org/W2157729659","https://openalex.org/W2159205678"],"related_works":["https://openalex.org/W3111474448","https://openalex.org/W2903789917","https://openalex.org/W6894139133","https://openalex.org/W4252498982","https://openalex.org/W2103778190","https://openalex.org/W7037930609","https://openalex.org/W2002863315","https://openalex.org/W1490045878","https://openalex.org/W3175381273","https://openalex.org/W2906846904"],"abstract_inverted_index":{"In":[0],"Saccharomyces":[1],"cerevisiae,":[2],"some":[3],"of":[4,28,45,59,66,77,104,116,126,166,171,175,181,194,204],"the":[5,13,17,29,33,46,53,60,63,67,75,78,82,85,89,105,123,127,143,151,155,159,167,176,189,195,200,205],"nascent":[6],"chains":[7],"can":[8],"be":[9],"post-translationally":[10],"translocated":[11],"into":[12,146],"endoplasmic":[14],"reticulum":[15],"through":[16],"heptameric":[18,90,144],"post-translational":[19,68],"translocon":[20,153],"complex":[21,25,39,87,91,145],"(post-translocon).":[22],"This":[23],"membrane-protein":[24],"is":[26,120],"composed":[27],"protein-conducting":[30,54],"channel":[31,55,83],"and":[32,56,80,84,158],"tetrameric":[34],"Sec62/63":[35,38,86],"complex.":[36],"The":[37,107],"plays":[40],"crucial":[41],"roles":[42],"in":[43,57,173,188],"targeting":[44],"signal":[47],"recognition":[48],"particle-independent":[49],"protein":[50],"substrate":[51],"to":[52,112],"assembly":[58,174],"post-translocon.":[61,106,196,207],"Although":[62],"molecular":[64],"mechanism":[65],"translocation":[69],"process":[70],"has":[71],"been":[72],"well":[73],"established,":[74],"structure":[76,103],"post-translocon":[79,109,177],"how":[81],"form":[88],"are":[92],"largely":[93],"uncharacterized.":[94],"Here,":[95],"we":[96],"report":[97],"a":[98,114,133,164],"20-\u00c5":[99],"resolution":[100],"cryo-electron":[101],"microscopy":[102],"purified":[108],"was":[110,178],"found":[111],"have":[113],"mass":[115],"287":[117],"kDa,":[118],"which":[119],"consistent":[121],"with":[122],"unit":[124],"stoichiometry":[125],"seven":[128],"subunits":[129],"as":[130,150],"determined":[131],"by":[132],"cysteine":[134],"labeling":[135],"experiment.":[136],"We":[137],"demonstrated":[138],"that":[139],"Triton":[140],"X-100":[141],"dissociated":[142],"three":[147],"subcomplexes":[148],"identified":[149],"trimeric":[152],"Sec61-Sbh1-Sss1,":[154],"Sec63-Sec71-Sec72":[156],"trimer,":[157],"heterotetramer":[160],"Sec62-Sec63-Sec71-Sec72,":[161],"respectively.":[162],"Additionally,":[163],"role":[165],"sixth":[168],"cytosolic":[169],"loop":[170,190],"Sec61":[172],"demonstrated.":[179],"Mutations":[180],"conserved,":[182],"positively":[183],"charged":[184],"amino":[185],"acid":[186],"residues":[187],"caused":[191],"decreased":[192],"formation":[193],"These":[197],"studies":[198],"provide":[199],"first":[201],"architectural":[202],"description":[203],"yeast":[206]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}