{"id":"https://openalex.org/W1982294875","doi":"https://doi.org/10.1158/1538-7445.am10-3500","title":"Abstract 3500: Nucleolytic processing of Topoisomerase 2 covalent complexes","display_name":"Abstract 3500: Nucleolytic processing of Topoisomerase 2 covalent complexes","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1982294875","doi":"https://doi.org/10.1158/1538-7445.am10-3500","mag":"1982294875"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-3500","doi":"https://doi.org/10.1158/1538-7445.am10-3500","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3500","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022566853","display_name":"John L. Nitiss","orcid":"https://orcid.org/0000-0002-1013-4972","observed_orcids":["https://orcid.org/0000-0002-1013-4972"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Nitiss","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074241171","display_name":"Karim Bahmed","orcid":"https://orcid.org/0000-0001-9854-5452","observed_orcids":["https://orcid.org/0000-0001-9854-5452","https://orcid.org/0000-0002-8932-1331"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karim Bahmed","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021713133","display_name":"Margarita Mishina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margarita Mishina","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111978354","display_name":"Jeffrey Berk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Berk","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072102696","display_name":"Karin C. Nitiss","orcid":"https://orcid.org/0000-0002-3548-5090","observed_orcids":["https://orcid.org/0000-0002-3548-5090"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin C. Nitiss","raw_affiliation_strings":["1St. Jude Children's Research Hospital, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St. Jude Children's Research Hospital, Memphis, TN","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"3500","last_page":"3500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.08309999853372574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.9309999942779541},{"id":"https://openalex.org/keywords/topoisomerase-poisons","display_name":"topoisomerase poisons","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tyrosyl-dna-phosphodiesterase-1","display_name":"TDP1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7799999713897705},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6780382394790649},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6545131206512451},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.638878583908081},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.5476903915405273},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5287743806838989},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5176792144775391},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.48299872875213623},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.4600972533226013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45440784096717834},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4538295865058899},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.44194912910461426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3767171800136566},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3660013675689697},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.2089012861251831},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15110120177268982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10834133625030518},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.09779495000839233},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.07268431782722473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-3500","doi":"https://doi.org/10.1158/1538-7445.am10-3500","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-3500","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007047273","https://openalex.org/W3209154032","https://openalex.org/W2017758927","https://openalex.org/W2774497860","https://openalex.org/W180056083","https://openalex.org/W4297003422","https://openalex.org/W2105602448","https://openalex.org/W1489501428","https://openalex.org/W2076418100","https://openalex.org/W7138045410"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"generation":[2],"of":[3,6,49,57,113,159,183,288,293],"elevated":[4],"levels":[5],"enzyme:":[7],"DNA":[8,22,32,52,72,85,163,185,245],"covalent":[9,177,259],"complexes":[10,178,260],"is":[11,54,60,120,202,216,235],"the":[12,47,55,111,114,117,127,131,157,160,181,198,228,232,264,289,294],"key":[13],"event":[14],"in":[15,46,227],"cell":[16,41],"killing":[17],"by":[18],"many":[19],"drugs":[20],"targeting":[21],"topoisomerases.":[23],"These":[24],"agents,":[25],"termed":[26],"topoisomerase":[27,50,274],"poisons":[28],"generate":[29],"protein":[30,58],"linked":[31,142,153],"strand":[33],"that":[34,59,90,124,156,197,208,224,230,251,263],"block":[35],"transcription":[36],"and":[37,75,78,261],"replication,":[38],"leading":[39],"to":[40,63,143,179,188,193,204,212,237,243,272],"death.":[42],"A":[43],"critical":[44],"step":[45],"repair":[48,67,186],"mediated":[51,275],"damage":[53,276],"removal":[56],"covalently":[61,191,210],"attached":[62],"DNA.":[64,194,213],"Several":[65],"specialized":[66],"enzymes,":[68],"including":[69],"Tdp1":[70,92,103,166],"(tyrosyl":[71],"phosphodiesterase":[73],"I)":[74],"TTRAP":[76],"(TRAF":[77],"TNF":[79],"receptor-associated":[80],"protein)":[81],"can":[82,104],"hydrolyze":[83,94,106],"phosphotyrosyl:":[84],"linkages.":[86,101],"We":[87,169,195],"previously":[88],"reported":[89],"yeast":[91,128,223],"could":[93],"5\u2032":[95,107,151],"as":[96,98],"well":[97],"3\u2032":[99],"phosphotyrosyl":[100,108],"Human":[102],"also":[105,170],"linkages,":[109],"although":[110],"efficiency":[112,148],"reaction":[115,167],"with":[116,126,146,218],"human":[118,132],"enzyme":[119,133],"much":[121],"less":[122],"than":[123,149],"seen":[125],"enzyme.":[129],"Interestingly,":[130],"processes":[134],"adducts":[135],"bearing":[136],"a":[137,150,225],"seven":[138],"amino":[139],"acid":[140],"peptide":[141],"an":[144],"oligonucleotide":[145],"greater":[147],"biotin":[152],"oligonucleotide,":[154],"suggesting":[155],"nature":[158],"adduct":[161],"at":[162,277],"ends":[164],"influences":[165],"kinetics.":[168],"used":[171],"substrates":[172],"derived":[173],"from":[174,222],"Top2":[175,206,238,258],"trapped":[176],"assess":[180],"ability":[182],"other":[184,244],"enzymes":[187],"remove":[189,205],"peptides":[190,207],"bound":[192,211],"found":[196],"heterodimeric":[199],"nuclease":[200,233],"Slx1/Slx4":[201,265],"able":[203],"are":[209,253],"This":[214],"result":[215],"consistent":[217],"our":[219],"genetic":[220],"data":[221],"mutation":[226],"subunit":[229],"includes":[231],"(Slx1)":[234],"hypersensitive":[236],"poisons,":[239],"but":[240],"not":[241],"sensitive":[242],"damaging":[246],"agents.":[247],"Our":[248],"results":[249],"indicate":[250],"there":[252],"multiple":[254],"pathways":[255],"for":[256,297],"repairing":[257,273],"suggest":[262],"dependent":[266],"pathway":[267],"may":[268],"be":[269],"particularly":[270],"relevant":[271],"replication":[278],"forks.":[279],"Citation":[280],"Format:":[281],"{Authors}.":[282],"{Abstract":[283],"title}":[284],"[abstract].":[285],"In:":[286],"Proceedings":[287],"101st":[290],"Annual":[291],"Meeting":[292],"American":[295],"Association":[296],"Cancer":[298,308],"Research;":[299],"2010":[300],"Apr":[301],"17-21;":[302],"Washington,":[303],"DC.":[304],"Philadelphia":[305],"(PA):":[306],"AACR;":[307],"Res":[309],"2010;70(8":[310],"Suppl):Abstract":[311],"nr":[312],"3500.":[313]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
