{"id":"https://openalex.org/W1982267342","doi":"https://doi.org/10.1002/jssc.200700582","title":"A simple method to optimize the HSCCC two\u2010phase solvent system by predicting the partition coefficient for target compound","display_name":"A simple method to optimize the HSCCC two\u2010phase solvent system by predicting the partition coefficient for target compound","publication_year":2008,"publication_date":"2008-02-27","ids":{"openalex":"https://openalex.org/W1982267342","doi":"https://doi.org/10.1002/jssc.200700582","mag":"1982267342","pmid":"https://pubmed.ncbi.nlm.nih.gov/18306210"},"language":"en","primary_location":{"id":"doi:10.1002/jssc.200700582","doi":"https://doi.org/10.1002/jssc.200700582","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jssc.200700582","pdf_url":null,"source":{"id":"https://openalex.org/S45406943","display_name":"Journal of Separation Science","issn_l":"1615-9306","issn":["1615-9306","1615-9314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Separation Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032785216","display_name":"Quan\u2010Bin Han","orcid":"https://orcid.org/0000-0001-9051-1485","observed_orcids":["https://orcid.org/0000-0001-9051-1485"]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Quan\u2010Bin Han","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084323599","display_name":"Lina Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lina Wong","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103109671","display_name":"Nian\u2010Yun Yang","orcid":"https://orcid.org/0000-0001-5544-9460","observed_orcids":["https://orcid.org/0000-0001-5544-9460"]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Nian\u2010Yun Yang","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036040585","display_name":"Jing\u2010Zheng Song","orcid":"https://orcid.org/0000-0002-5821-7638","observed_orcids":["https://orcid.org/0000-0002-5821-7638"]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jing\u2010Zheng Song","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101120164","display_name":"Chun\u2010Feng Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Chun\u2010Feng Qiao","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016461954","display_name":"Hillary Yiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100650","display_name":"Hong Kong Jockey Club","ror":"https://ror.org/015ygrv52","country_code":"HK","type":"nonprofit","lineage":["https://openalex.org/I4210100650"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hillary Yiu","raw_affiliation_strings":["Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China","institution_ids":["https://openalex.org/I4210100650"]},{"raw_affiliation_string":"Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, China. Fax: +852-3551-7333","institution_ids":["https://openalex.org/I4210100650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029128268","display_name":"Yoichiro Ito","orcid":"https://orcid.org/0000-0001-9018-295X","observed_orcids":["https://orcid.org/0000-0001-9018-295X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoichiro Ito","raw_affiliation_strings":["Center for Biochemistry and Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biochemistry and Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034735808","display_name":"Hong\u2010Xi Xu","orcid":"https://orcid.org/0000-0001-6238-4511","observed_orcids":["https://orcid.org/0000-0001-6238-4511","https://orcid.org/0009-0000-7270-2149","https://orcid.org/0000-0002-1772-4844"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hong\u2010Xi Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034735808"],"corresponding_institution_ids":[],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":3.0265,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.88562946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"6-7","first_page":"1189","last_page":"1194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-speed-countercurrent-chromatography","display_name":"high-speed countercurrent chromatography","score":0.9779999852180481},{"id":"https://openalex.org/keywords/solvent-ratio","display_name":"solvent ratio","score":0.7879999876022339},{"id":"https://openalex.org/keywords/partition-coefficient-prediction","display_name":"partition coefficient prediction","score":0.921999990940094},{"id":"https://openalex.org/keywords/pseudolaric-acid-b","display_name":"pseudolaric acid B","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pseudolarix-kaempferi","display_name":"Pseudolarix kaempferi","score":0.9990000128746033},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.8814019560813904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7419129610061646},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.6845853328704834},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6426436305046082},{"id":"https://openalex.org/C63258622","wikidata":"https://www.wikidata.org/wiki/Q1498317","display_name":"Countercurrent chromatography","level":3,"score":0.6209774017333984},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4542841911315918},{"id":"https://openalex.org/C2777077568","wikidata":"https://www.wikidata.org/wiki/Q150440","display_name":"Hexane","level":2,"score":0.4542544186115265},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.3814603090286255},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18199065327644348}],"mesh":[{"descriptor_ui":"D003377","descriptor_name":"Countercurrent Distribution","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D028201","descriptor_name":"Pinaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jssc.200700582","doi":"https://doi.org/10.1002/jssc.200700582","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jssc.200700582","pdf_url":null,"source":{"id":"https://openalex.org/S45406943","display_name":"Journal of Separation Science","issn_l":"1615-9306","issn":["1615-9306","1615-9314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Separation Science","raw_type":"journal-article"},{"id":"pmid:18306210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18306210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of separation science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1968618650","https://openalex.org/W1969776525","https://openalex.org/W1971866096","https://openalex.org/W1984297788","https://openalex.org/W1987135617","https://openalex.org/W1999737354","https://openalex.org/W2010149351","https://openalex.org/W2018592925","https://openalex.org/W2040599657","https://openalex.org/W2045720951","https://openalex.org/W2059610658","https://openalex.org/W2069909939","https://openalex.org/W2070059667","https://openalex.org/W2075380544","https://openalex.org/W2082641529","https://openalex.org/W2084680279","https://openalex.org/W2106223136","https://openalex.org/W2111962211"],"related_works":["https://openalex.org/W4249958866","https://openalex.org/W4309161465","https://openalex.org/W2498370576","https://openalex.org/W2008930750","https://openalex.org/W3044641433","https://openalex.org/W3096531301","https://openalex.org/W1999737354","https://openalex.org/W1656778068","https://openalex.org/W2278261671","https://openalex.org/W2072767707"],"abstract_inverted_index":{"A":[0],"simple":[1],"method":[2,75],"was":[3,56,76,110,129],"developed":[4],"to":[5,36,59],"optimize":[6],"the":[7,11,17,28,31,38,41,45,52,66,70,81,86,94,135],"solvent":[8,13,42,54,83,103],"ratio":[9,43],"of":[10,69,89,105,125,134,141],"two-phase":[12,53,82,102],"system":[14,55,84,104],"used":[15,111],"in":[16,79],"high-speed":[18],"counter-current":[19],"chromatography":[20],"(HSCCC)":[21],"separation.":[22],"Some":[23],"mathematic":[24],"equations,":[25,33],"such":[26],"as":[27],"exponential":[29],"and":[30,44],"power":[32],"were":[34],"established":[35],"describe":[37],"relationship":[39],"between":[40],"partition":[46,63,115],"coefficient.":[47],"Using":[48],"this":[49,74],"new":[50],"method,":[51],"easily":[57],"optimized":[58],"obtain":[60],"a":[61,113,121,139],"proper":[62],"coefficient":[64,116],"for":[65,85],"CCC":[67],"separation":[68],"target":[71],"compound.":[72],"Furthermore,":[73],"satisfactorily":[77],"applied":[78],"determining":[80],"HSCCC":[87],"preparation":[88],"pseudolaric":[90,126],"acid":[91,127],"B":[92,128],"from":[93,131],"Chinese":[95],"herb":[96],"Pseudolarix":[97],"kaempferi":[98],"Gordon":[99],"(Pinaceae).":[100],"The":[101],"n-hexane/EtOAc/MeOH/H(2)O":[106],"(5:5:5:5":[107],"by":[108,143],"volume)":[109],"with":[112,138],"good":[114],"K":[117],"=":[118],"1.08.":[119],"As":[120],"result,":[122],"232.05":[123],"mg":[124],"yielded":[130],"0.5":[132],"g":[133],"crude":[136],"extract":[137],"purity":[140],"97.26%":[142],"HPLC":[144],"analysis.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}