{"id":"https://openalex.org/W1982257667","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","title":"A non\u2010thrombocytopenic bleeding disorder due to an IgG4\u2010kappa anti\u2010GPIIb/IIIa autoantibody","display_name":"A non\u2010thrombocytopenic bleeding disorder due to an IgG4\u2010kappa anti\u2010GPIIb/IIIa autoantibody","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W1982257667","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","mag":"1982257667","pmid":"https://pubmed.ncbi.nlm.nih.gov/8982055"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.1996.d01-1957.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110901531","display_name":"Robert McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. McMillan","raw_affiliation_strings":["Scripps Research Institute, Lajolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scripps Research Institute, Lajolla, California 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110273810","display_name":"Ron D. Bowditch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. D. Bowditch","raw_affiliation_strings":["The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014660411","display_name":"Patricia H. Tani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Tani","raw_affiliation_strings":["The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Anderson","raw_affiliation_strings":["The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109048779","display_name":"Scott H. Goodnight","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Goodnight","raw_affiliation_strings":["The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, LaJolla, California, and Oregon Health Sciences University, Portland, Oregon, U.S.A","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110901531"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.6488,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.67445743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"4","first_page":"747","last_page":"749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fibrinogen-binding","display_name":"fibrinogen binding","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fibronectin-binding","display_name":"fibronectin binding","score":0.9919999837875366},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mucosal-bleeding","display_name":"mucosal bleeding","score":0.9419999718666077},{"id":"https://openalex.org/keywords/prolonged-bleeding-time","display_name":"prolonged bleeding time","score":0.8629999756813049},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chronic-immune-thrombocytopenic-purpura","display_name":"chronic ITP","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.9345593452453613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.80487060546875},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.748837411403656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5833702683448792},{"id":"https://openalex.org/C2779771385","wikidata":"https://www.wikidata.org/wiki/Q6132707","display_name":"Thrombocytopenic purpura","level":3,"score":0.5226185917854309},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5149469971656799},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.5110105276107788},{"id":"https://openalex.org/C26828662","wikidata":"https://www.wikidata.org/wiki/Q7202248","display_name":"Platelet membrane glycoprotein","level":3,"score":0.4751151502132416},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.4142792224884033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41356760263442993},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001760","descriptor_name":"Bleeding Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003108","descriptor_name":"Colonic Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003108","descriptor_name":"Colonic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007145","descriptor_name":"Immunoglobulin kappa-Chains","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.1996.d01-1957.x","doi":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1996.d01-1957.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:8982055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8982055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G1655645242","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR000833","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2439430869","display_name":null,"funder_award_id":"HL 37945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4071581116","display_name":"IN VITRO EVOLUTION OF FIBRONECTIN","funder_award_id":"5r29gm051616-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4903781541","display_name":null,"funder_award_id":"GM51616","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5029637385","display_name":"PATHOGENESIS OF THE IMMUNE THROMBOCYTOPENIAS","funder_award_id":"5r01hl037945-23","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G809017099","display_name":null,"funder_award_id":"RR-00833","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2465875584","https://openalex.org/W1598701272","https://openalex.org/W1480237455","https://openalex.org/W306305787","https://openalex.org/W186659478","https://openalex.org/W2398313758","https://openalex.org/W1982177692","https://openalex.org/W2015971012","https://openalex.org/W2247400229","https://openalex.org/W2007403885"],"abstract_inverted_index":{"Autoantibodies":[0],"in":[1,67,74,81],"chronic":[2],"immune":[3],"thrombocytopenic":[4],"purpura":[5],"occasionally":[6],"interfere":[7],"with":[8,15],"platelet":[9,18,32,50],"function.":[10],"We":[11],"describe":[12],"a":[13,16,26,46,71],"patient":[14,35],"normal":[17],"count":[19],"who":[20],"had":[21,36],"clinically":[22],"significant":[23],"mucosal":[24],"bleeding,":[25],"prolonged":[27],"bleeding":[28],"time":[29],"and":[30,59,70],"abnormal":[31],"aggregation.":[33],"The":[34,77],"high":[37,85],"titres":[38],"of":[39,57,79,95],"an":[40],"IgG4":[41,96],"kappa":[42],"autoantibody,":[43],"directed":[44],"to":[45,61],"cation-dependent":[47],"epitope":[48],"on":[49],"glycoprotein":[51],"IIb/IIIa,":[52],"which":[53],"blocked":[54],"the":[55,92],"binding":[56],"fibrinogen":[58],"fibronectin":[60],"this":[62,82],"complex.":[63],"Corticosteroid":[64],"treatment":[65],"resulted":[66],"clinical":[68],"improvement":[69],"marked":[72],"drop":[73],"autoantibody":[75,86],"concentration.":[76],"lack":[78],"thrombocytopenia":[80],"patient,":[83],"despite":[84],"levels,":[87],"is":[88],"best":[89],"explained":[90],"by":[91,98],"poor":[93],"recognition":[94],"antibodies":[97],"phagocytic":[99],"cells.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}