{"id":"https://openalex.org/W1982246779","doi":"https://doi.org/10.1507/endocrj.41.267","title":"Steroid Contents and Cortical Steroidogenic Enzymes in Non-Hyperfunctioning Adrenal Adenoma.","display_name":"Steroid Contents and Cortical Steroidogenic Enzymes in Non-Hyperfunctioning Adrenal Adenoma.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W1982246779","doi":"https://doi.org/10.1507/endocrj.41.267","mag":"1982246779","pmid":"https://pubmed.ncbi.nlm.nih.gov/7951578"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.41.267","doi":"https://doi.org/10.1507/endocrj.41.267","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.41.267","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/41/3/41_3_267/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj1993/41/3/41_3_267/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034957670","display_name":"HIROMIGHI SUZUKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROMIGHI SUZUKI","raw_affiliation_strings":["Departments of Internal Medicine, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084913194","display_name":"Hirotaka Shibata","orcid":"https://orcid.org/0000-0001-6506-4820","observed_orcids":["https://orcid.org/0000-0001-6506-4820"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROTAKA SHIBATA","raw_affiliation_strings":["Departments of Internal Medicine, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037244","display_name":"Takashi Takita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKASHI TAKITA","raw_affiliation_strings":["Departments of Internal Medicine, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089373241","display_name":"Shu Wakino","orcid":"https://orcid.org/0000-0003-1677-8397","observed_orcids":["https://orcid.org/0000-0003-1677-8397"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHU WAKINO","raw_affiliation_strings":["Departments of Internal Medicine, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072870985","display_name":"Tadashi Ogishima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TADASHI OGISHIMA","raw_affiliation_strings":["Departments of Biochemistry, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065552630","display_name":"Yuzuru Ishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUZURU ISHIMURA","raw_affiliation_strings":["Departments of Biochemistry, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108254709","display_name":"Takao Saruta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKAO SARUTA","raw_affiliation_strings":["Departments of Internal Medicine, School of Medicine, Keio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Internal Medicine, School of Medicine, Keio University","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":null,"apc_paid":null,"fwci":3.1494,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.90711123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"3","first_page":"267","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenal-incidentaloma","display_name":"adrenal incidentaloma","score":0.8690000176429749},{"id":"https://openalex.org/keywords/adrenal-adenoma","display_name":"adrenal adenoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/steroidogenic-enzymes","display_name":"steroidogenic enzymes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cytochrome-p450scc","display_name":"cytochrome P450scc","score":0.8930000066757202},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.8809999823570251},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.5960000157356262},{"id":"https://openalex.org/keywords/glucocorticoid-pathway","display_name":"glucocorticoid pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adrenocortical-tumors","display_name":"adrenocortical tumors","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.719282329082489},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.5774579048156738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5689722895622253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5310260057449341},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5166366696357727},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.49698904156684875},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.4927988350391388},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.4504290223121643},{"id":"https://openalex.org/C2778914232","wikidata":"https://www.wikidata.org/wiki/Q4684749","display_name":"Adrenal adenoma","level":3,"score":0.430475115776062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3743640184402466},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3545539975166321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33758920431137085},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.31311100721359253}],"mesh":[{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000308","descriptor_name":"Adrenocortical Hyperfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002763","descriptor_name":"Cholecystectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005743","descriptor_name":"Gastrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018246","descriptor_name":"Adrenocortical Adenoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018246","descriptor_name":"Adrenocortical Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018246","descriptor_name":"Adrenocortical Adenoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj.41.267","doi":"https://doi.org/10.1507/endocrj.41.267","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.41.267","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/41/3/41_3_267/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:7951578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7951578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1507/endocrj.41.267","doi":"https://doi.org/10.1507/endocrj.41.267","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.41.267","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj1993/41/3/41_3_267/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982246779.pdf","grobid_xml":"https://content.openalex.org/works/W1982246779.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W133187153","https://openalex.org/W284827812","https://openalex.org/W1481279942","https://openalex.org/W1577500416","https://openalex.org/W1605230574","https://openalex.org/W1972614561","https://openalex.org/W1975086413","https://openalex.org/W1980328605","https://openalex.org/W1984100207","https://openalex.org/W1993316713","https://openalex.org/W2008197398","https://openalex.org/W2008699886","https://openalex.org/W2009958449","https://openalex.org/W2010453222","https://openalex.org/W2011954097","https://openalex.org/W2015412072","https://openalex.org/W2024189326","https://openalex.org/W2034254601","https://openalex.org/W2034928436","https://openalex.org/W2037425536","https://openalex.org/W2075844800","https://openalex.org/W2081938215","https://openalex.org/W2083653370","https://openalex.org/W2084839695","https://openalex.org/W2086031560","https://openalex.org/W2100837269","https://openalex.org/W2135877881","https://openalex.org/W2240705674","https://openalex.org/W2291903346","https://openalex.org/W2395369325","https://openalex.org/W2410831227","https://openalex.org/W2733197546","https://openalex.org/W4226226340"],"related_works":["https://openalex.org/W1963604912","https://openalex.org/W2059564047","https://openalex.org/W4252226503","https://openalex.org/W2009439285","https://openalex.org/W1964590563","https://openalex.org/W1971170617","https://openalex.org/W2046136148","https://openalex.org/W2414981528","https://openalex.org/W2135877881","https://openalex.org/W4297256383"],"abstract_inverted_index":{"The":[0,270],"recent":[1],"increasing":[2],"use":[3],"of":[4,12,29,52,103,111,141,155,182,210,220,237,257,267,301,309],"ultrasound":[5],"and":[6,74,86,97,101,135,138,145,152,165,207,218,227,239,287,296],"computed":[7],"tomography":[8],"has":[9],"revealed":[10,118],"numbers":[11],"incidentally":[13],"discovered":[14],"adrenal":[15,31,53,172,214,259,268,275,278],"tumors.":[16],"Many":[17],"studies":[18],"have":[19,33],"focused":[20],"on":[21],"their":[22],"surgical":[23],"management,":[24],"but":[25],"the":[26,64,99,108,120,129,139,143,176,180,199,216,232,235,242,250,258,265,285,299,307],"biological":[27],"characteristics":[28],"these":[30,112],"tumors":[32,37,85,121,173,215,256],"remained":[34],"unclear.":[35],"Adrenal":[36],"were":[38,58,80,88,114,122,148,174,229,245,261],"resected":[39,171,213],"from":[40,311],"10":[41],"patients":[42,113,184],"who":[43],"underwent":[44],"gastrectomy":[45],"or":[46,50,56,62],"cholecystectomy.":[47],"No":[48],"signs":[49,73],"symptoms":[51,75],"hormone":[54],"excess":[55],"deficiency":[57],"evident":[59],"either":[60],"before":[61],"after":[63,67],"operation.":[65],"Moreover,":[66],"surgery,":[68,83],"no":[69],"major":[70],"differences":[71],"in":[72,107,150,169,191,198,204,241,249,263,283,293,298,303],"including":[76],"blood":[77],"pressure":[78],"levels":[79],"observed.":[81],"Before":[82],"neurogenic":[84],"cysts":[87],"excluded":[89],"by":[90,124],"enhanced":[91],"magnetic":[92],"resonance":[93],"imaging.":[94],"Steroid":[95],"contents":[96],"both":[98,142,205,284],"activities":[100,217,236,300],"amounts":[102,219],"steroidogenic":[104,281],"cytochrome":[105,221],"P-450s":[106,222],"adrenocortical":[109],"adenomas":[110],"examined.":[115],"Microscopic":[116],"examination":[117],"that":[119,274],"surrounded":[123],"a":[125,312,316],"thin,":[126],"non-intact":[127],"capsule;":[128],"surrounding":[130],"cortex":[131],"was":[132,194],"not":[133],"atrophic":[134],"apparently":[136,200],"normal;":[137],"cells":[140],"tumor":[144,192,206,243,286,304],"adjacent":[146,208,251,288],"portions":[147,193,209,305],"arranged":[149],"nests":[151],"cords.":[153],"Measurements":[154],"all":[156,264],"steroid":[157],"content":[158,190,295],"(pregnenolone,":[159],"progesterone,":[160],"corticosterone,":[161],"11-deoxycorticosterone,":[162],"18-hydroxydeoxycorticosterone,":[163],"cortisol,":[164],"dehydroepiandrosterone)":[166],"except":[167],"aldosterone":[168,294],"5":[170,183,212],"within":[175,231],"normal":[177,201,233],"ranges":[178],"for":[179],"adrenals":[181],"with":[185],"renal":[186],"cell":[187],"carcinoma.":[188],"Aldosterone":[189],"significantly":[195],"lower":[196],"than":[197,247],"adrenals.":[202],"Although":[203],"another":[211],"(P-450scc',":[223],"P-45011\u03b2',":[224],"P-450aldo',":[225],"P-45017\u03b1',":[226],"P-450c21)":[228],"also":[230],"ranges,":[234],"P-450scc":[238],"P-45017a":[240],"portion":[244],"greater":[246],"those":[248],"portion.":[252],"Grossly":[253],"well-demarcated":[254],"yellowish-brown":[255],"gland":[260],"observed":[262],"cases":[266],"tumor.":[269],"above":[271],"results":[272],"suggested":[273],"incidentalomas":[276],"produce":[277],"steroids":[279],"through":[280],"enzymes":[282],"portions.":[289],"In":[290],"addition,":[291],"decreases":[292],"increases":[297],"P-45017\u03b1":[302],"suggest":[306],"shift":[308],"steroidogenesis":[310],"mineralocorticoid":[313],"pathway":[314],"to":[315],"glucocorticoid":[317],"pathway.":[318]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}