{"id":"https://openalex.org/W1982245802","doi":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","title":"Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins","display_name":"Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W1982245802","doi":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","mag":"1982245802","pmid":"https://pubmed.ncbi.nlm.nih.gov/1374201"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-6576.1992.tb03463.x","doi":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013408923","display_name":"M. A. Claeys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M. A. Claeys","raw_affiliation_strings":["Department of Anesthesiology, Flemish Free University of Brussels, Belgium","Department of Anesthesiology, Flemish Free University of Brussels, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Flemish Free University of Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"Department of Anesthesiology, Flemish Free University of Brussels, Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111768873","display_name":"F. Camu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"F. Camu","raw_affiliation_strings":["Department of Anesthesiology, Flemish Free University of Brussels, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Flemish Free University of Brussels, Brussels, Belgium","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111368110","display_name":"V\u00e9ronique Maes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Maes","raw_affiliation_strings":["Department of Clinical Toxicology, Flemish Free University of Brussels, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Toxicology, Flemish Free University of Brussels, Brussels, Belgium","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111768873"],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":1.717,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81307317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"36","issue":"3","first_page":"270","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9980000257492065},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/preoperative-analgesia","display_name":"preoperative analgesia","score":0.8320000171661377},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9779999852180481},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.949999988079071},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":0.9150000214576721},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"haptoglobin","score":0.871999979019165},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/muscle-enzymes","display_name":"muscle enzymes","score":0.492000013589859},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/piritramide","display_name":"piritramide","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9545116424560547},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.9235962629318237},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7127901315689087},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6868895888328552},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.6308141946792603},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5288326144218445},{"id":"https://openalex.org/C2778139025","wikidata":"https://www.wikidata.org/wiki/Q408676","display_name":"Piroxicam","level":3,"score":0.440355509519577},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40997934341430664},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004008","descriptor_name":"Diclofenac","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009985","descriptor_name":"Orthopedics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1399-6576.1992.tb03463.x","doi":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.1992.tb03463.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:1374201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1374201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anaesthesiologica Scandinavica","raw_type":"Clinical Trial"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/331453","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/331453","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta anaesthesiologica Scandinavica, 36 (3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W263242318","https://openalex.org/W1965506226","https://openalex.org/W1985524708","https://openalex.org/W1995762213","https://openalex.org/W1997697804","https://openalex.org/W2016338678","https://openalex.org/W2018467822","https://openalex.org/W2026230456","https://openalex.org/W2034670434","https://openalex.org/W2035274118","https://openalex.org/W2045188807","https://openalex.org/W2048215075","https://openalex.org/W2055541814","https://openalex.org/W2060068127","https://openalex.org/W2073134794","https://openalex.org/W2076565784","https://openalex.org/W2080456908","https://openalex.org/W2088098780","https://openalex.org/W2092936332","https://openalex.org/W2138002039","https://openalex.org/W2207258656","https://openalex.org/W2241489262","https://openalex.org/W2265636639"],"related_works":["https://openalex.org/W2241489262","https://openalex.org/W1966755795","https://openalex.org/W4313236590","https://openalex.org/W2034670434","https://openalex.org/W4230093203","https://openalex.org/W2026230456","https://openalex.org/W2016157404","https://openalex.org/W2079858439","https://openalex.org/W2107391503","https://openalex.org/W2307540092"],"abstract_inverted_index":{"The":[0,58,115],"influence":[1,120],"of":[2,50,65,87],"diclofenac,":[3],"given":[4],"by":[5,46],"continuous":[6],"i.v.":[7],"infusion":[8,49],"starting":[9],"preoperatively,":[10],"on":[11,69,121,127],"postoperative":[12],"pain":[13,59],"and":[14,62,80,104,123,129,138],"inflammation":[15,94],"was":[16],"assessed":[17],"in":[18,24,74,109,132],"a":[19,47],"double-blind,":[20],"randomized,":[21],"placebo-controlled":[22],"study":[23],"40":[25],"patients":[26,38,137],"scheduled":[27],"for":[28,55,112],"major":[29],"orthopedic":[30],"surgery.":[31],"Starting":[32],"30":[33],"min":[34],"before":[35],"induction":[36],"the":[37,63,75,141,148],"received":[39],"either":[40],"diclofenac":[41,76,116,142],"(0.35":[42],"mg.kg-1":[43],"bolus":[44],"followed":[45],"constant-rate":[48],"90":[51],"micrograms.min-1)":[52],"or":[53],"placebo":[54,149],"24":[56,113],"h.":[57,114],"intensity":[60],"(VAS)":[61],"amount":[64],"rescue":[66],"narcotic":[67],"(piritramide":[68],"demand)":[70],"were":[71],"significantly":[72,145],"lower":[73],"group":[77],"from":[78],"4":[79],"6":[81],"h":[82],"postsurgery,":[83],"respectively,":[84],"till":[85],"end":[86],"infusion.":[88],"Acute":[89],"phase":[90],"proteins":[91],"used":[92],"as":[93,144],"markers":[95],"(C-reactive":[96],"protein,":[97],"alpha":[98,100],"1-chymotrypsin,":[99],"1-acid":[101],"glycoprotein,":[102],"haptoglobin":[103],"coeruloplasmin)":[105],"showed":[106],"similar":[107],"variations":[108],"both":[110],"groups":[111],"treatment":[117,143],"had":[118],"no":[119],"hematological":[122],"coagulation":[124],"profiles,":[125],"nor":[126],"muscle":[128],"liver":[130],"enzymes":[131],"comparison":[133],"with":[134],"placebo.":[135],"Both":[136],"observer":[139],"rated":[140],"superior":[146],"to":[147],"treatment.":[150]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}