{"id":"https://openalex.org/W1982207252","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","title":"Granulocyte-colony stimulating factor and multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy in children with neuroblastoma","display_name":"Granulocyte-colony stimulating factor and multiple cycles of strongly myelosuppressive alkylator-based combination chemotherapy in children with neuroblastoma","publication_year":2000,"publication_date":"2000-11-15","ids":{"openalex":"https://openalex.org/W1982207252","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","mag":"1982207252","pmid":"https://pubmed.ncbi.nlm.nih.gov/11066054"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820001115%2989%3A10%3C2122%3A%3AAID-CNCR13%3E3.0.CO%3B2-K","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043729995","display_name":"Brian H. Kushner","orcid":"https://orcid.org/0000-0002-8916-0697","observed_orcids":["https://orcid.org/0000-0002-8916-0697"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian H. Kushner","raw_affiliation_strings":["","Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York","Fax (212) 717-3239"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Fax (212) 717-3239","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031035765","display_name":"Glenn Heller","orcid":"https://orcid.org/0000-0001-9217-8348","observed_orcids":["https://orcid.org/0000-0001-9217-8348"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Heller","raw_affiliation_strings":["Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034325765","display_name":"Kim Kramer","orcid":"https://orcid.org/0000-0002-3803-878X","observed_orcids":["https://orcid.org/0000-0002-3803-878X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Kramer","raw_affiliation_strings":["Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034081882","display_name":"Nai\u2010Kong V. Cheung","orcid":"https://orcid.org/0000-0001-6323-5171","observed_orcids":["https://orcid.org/0000-0001-6323-5171"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Kong V. Cheung","raw_affiliation_strings":["Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043729995"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.8774,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.74342894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"89","issue":"10","first_page":"2122","last_page":"2130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pediatric-cancer-chemotherapy","display_name":"pediatric cancer chemotherapy","score":0.5360000133514404},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8949999809265137},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8709999918937683},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7950000166893005},{"id":"https://openalex.org/keywords/neutrophil-recovery","display_name":"neutrophil recovery","score":0.7630000114440918},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5809999704360962},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/dose-intensity","display_name":"dose intensity","score":0.5910000205039978},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.4059999883174896},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.861758828163147},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.7687225341796875},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7405750751495361},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6436237692832947},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6355069875717163},{"id":"https://openalex.org/C2777767877","wikidata":"https://www.wikidata.org/wiki/Q419327","display_name":"Granulocyte colony-stimulating factor","level":3,"score":0.6141269207000732},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5741177797317505},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.5696192979812622},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.4666343331336975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4524496793746948},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4431607723236084},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.42073068022727966},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40184324979782104},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35608142614364624},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019046","descriptor_name":"Bone Marrow Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.0.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820001115%2989%3A10%3C2122%3A%3AAID-CNCR13%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:11066054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11066054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","doi":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(20001115)89:10<2122::aid-cncr13>3.3.co;2-b","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2820001115%2989%3A10%3C2122%3A%3AAID-CNCR13%3E3.0.CO%3B2-K","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1117419297","display_name":null,"funder_award_id":"CA72868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1516860519","display_name":"NOVEL COMBINATION THERAPY OF NEUROBLASTOMA","funder_award_id":"5r01ca061017-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1836322885","display_name":null,"funder_award_id":"CA61017","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5673822214","display_name":"INTRATHECAL RADIOIMMUNOTHERAPY OF CNS MALIGNANCIES","funder_award_id":"K08CA072868","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982207252.pdf","grobid_xml":"https://content.openalex.org/works/W1982207252.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W5946015","https://openalex.org/W142692312","https://openalex.org/W190074194","https://openalex.org/W340792320","https://openalex.org/W1577478964","https://openalex.org/W1578149674","https://openalex.org/W1819462601","https://openalex.org/W1826533514","https://openalex.org/W1843066912","https://openalex.org/W1912136430","https://openalex.org/W1974464773","https://openalex.org/W1986979881","https://openalex.org/W1987787394","https://openalex.org/W2009956281","https://openalex.org/W2012840335","https://openalex.org/W2032853726","https://openalex.org/W2037592227","https://openalex.org/W2039667116","https://openalex.org/W2061928026","https://openalex.org/W2063668342","https://openalex.org/W2072224250","https://openalex.org/W2079118792","https://openalex.org/W2079895822","https://openalex.org/W2096398040","https://openalex.org/W2100055648","https://openalex.org/W2102050352","https://openalex.org/W2108217627","https://openalex.org/W2134641172","https://openalex.org/W2140045275","https://openalex.org/W2171717143","https://openalex.org/W2226490553","https://openalex.org/W2228058953","https://openalex.org/W2257281028","https://openalex.org/W2324671927","https://openalex.org/W2336479938","https://openalex.org/W2398604372","https://openalex.org/W2414547622","https://openalex.org/W2796532176","https://openalex.org/W3145810101","https://openalex.org/W4247585355","https://openalex.org/W4255803928","https://openalex.org/W4299715941","https://openalex.org/W6666320251"],"related_works":["https://openalex.org/W2414547622","https://openalex.org/W1964419604","https://openalex.org/W1999412907","https://openalex.org/W2079895822","https://openalex.org/W2061928026","https://openalex.org/W4256404915","https://openalex.org/W2009956281","https://openalex.org/W3151204386","https://openalex.org/W2316834174","https://openalex.org/W201280849"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,355],"authors":[2],"assessed":[3],"key":[4],"effects":[5],"of":[6,16,39,177,210,246,307,315,326,353,361],"granulocyte-colony":[7],"stimulating":[8],"factor":[9],"(G-CSF)":[10],"used":[11,126,137],"prophylactically":[12],"with":[13,58,197,259,266,280,343],"multiple":[14,305],"cycles":[15,74,90,306],"strongly":[17,308],"myelosuppressive":[18,309],"alkylator-based":[19,310],"combination":[20,311],"chemotherapy.":[21],"To":[22,95],"the":[23,105,157,237,256,274,300,324],"authors'":[24],"knowledge,":[25],"no":[26,242,348],"large":[27],"study":[28],"has":[29,41],"focused":[30],"on":[31,164,244,332,350],"G-CSF":[32,135,238,240,257,283,316],"in":[33,73,89,184,212,236,255,276,299],"this":[34,37],"setting,":[35],"yet":[36],"kind":[38],"treatment":[40],"recently":[42],"become":[43],"standard":[44],"for":[45],"poor":[46],"risk":[47],"pediatric":[48],"solid":[49],"tumors":[50],"such":[51],"as":[52,102,104],"neuroblastoma.":[53,354],"PATIENTS":[54],"AND":[55],"METHODS.":[56],"Children":[57],"neuroblastoma":[59],"received":[60],"cyclophosphamide":[61],"140":[62],"mg/kg":[63],"(i.e.,":[64],"4200":[65],"mg/m(2)),":[66],"doxorubicin":[67],"75":[68],"mg/m(2),":[69],"and":[70,78,80,84,93,115,191,221,346],"vincristine":[71],"(CAV)":[72],"1,":[75],"2,":[76],"4,":[77],"6":[79],"cisplatin":[81],"200":[82],"mg/m(2)":[83,87],"etoposide":[85],"600":[86],"(P/VP)":[88],"3,":[91,282],"5,":[92],"7.":[94],"maximize":[96],"dose":[97,339],"intensity,":[98,340],"chemotherapy":[99,155],"was":[100,110,118,136,159,169,194,233,273,341],"begun":[101],"soon":[103],"absolute":[106],"neutrophil":[107],"count":[108,117],"(ANC)":[109],">":[111,119,160,170,217,222,291],"or":[112,120,161,168,171,218,223,292],"=":[113,121,132,145,162,172,219,224,262,293],"500/microL":[114,163,193,228],"platelet":[116,289],"100,000/microL.":[122,294],"No":[123],"cytokines":[124],"were":[125,251,297],"during":[127],"1990-1994":[128],"(control":[129],"group;":[130,143],"n":[131,144],"28),":[133],"but":[134,264,320],"from":[138,151],"1995":[139],"to":[140,181,189,192,227,231,288],"1998":[141],"(G-CSF":[142],"30)":[146],"at":[147],"5":[148],"microg/kg/day":[149],"subcutaneously":[150],"1":[152],"day":[153],"after":[154],"until":[156],"ANC":[158,318],"2":[165],"successive":[166],"days":[167],"1000/microL.":[173],"RESULTS:":[174],"Each":[175],"cycle":[176,271,281],"CAV":[178,260],"decreased":[179],"ANCs":[180,216],"<":[182],"200/microL":[183,190,220],"all":[185],"58":[186],"patients;":[187],"recovery":[188,226,287,319],"significantly":[195,234],"sooner":[196],"G-CSF.":[198,362],"In":[199],"contrast,":[200],"P/VP":[201],"did":[202,321,335],"not":[203,230,265,322,336],"invariably":[204],"cause":[205],"severe":[206],"neutropenia:":[207],"similar":[208,298],"numbers":[209],"patients":[211,284],"each":[213],"group":[214,258],"maintained":[215],"500/microL;":[225],"(but":[229],"200/microL)":[232],"faster":[235],"group.":[239],"had":[241,285,329,347],"impact":[243,331],"rates":[245,296,352],"febrile":[247,327],"episodes.":[248],"Bacterial/fungal":[249],"infections":[250],"slightly":[252],"less":[253],"frequent":[254],"(P":[261],"0.11)":[263],"P/VP.":[267],"Dose":[268],"intensity":[269],"through":[270],"4":[272],"same":[275],"both":[277],"groups.":[278,302],"Beginning":[279],"slower":[286],"counts":[290],"Response":[295],"two":[301],"CONCLUSIONS:":[303],"With":[304],"chemotherapy,":[312],"prophylactic":[313],"use":[314,360],"hastened":[317],"reduce":[323],"incidence":[325],"episodes,":[328],"little":[330],"infection":[333],"rates,":[334],"yield":[337],"augmented":[338],"associated":[342],"prolonged":[344],"thrombocytopenia,":[345],"effect":[349],"response":[351],"data":[356],"support":[357],"more":[358],"limited":[359]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}