{"id":"https://openalex.org/W1982164530","doi":"https://doi.org/10.1038/sj.leu.2404508","title":"Antitumor activity of sorafenib in FLT3-driven leukemic cells","display_name":"Antitumor activity of sorafenib in FLT3-driven leukemic cells","publication_year":2007,"publication_date":"2007-01-04","ids":{"openalex":"https://openalex.org/W1982164530","doi":"https://doi.org/10.1038/sj.leu.2404508","mag":"1982164530","pmid":"https://pubmed.ncbi.nlm.nih.gov/17205056"},"language":"en","primary_location":{"id":"doi:10.1038/sj.leu.2404508","doi":"https://doi.org/10.1038/sj.leu.2404508","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2404508","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055000089","display_name":"Daniel Auclair","orcid":"https://orcid.org/0000-0001-5151-3058","observed_orcids":["https://orcid.org/0000-0001-5151-3058"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D Auclair","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT 06516, USA. daniel.auclair.b@bayer.com","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT 06516, USA. daniel.auclair.b@bayer.com","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Miller","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049859804","display_name":"Victoria Yatsula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Yatsula","raw_affiliation_strings":["Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W Pickett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Pickett","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061339059","display_name":"C Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Carter","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037271959","display_name":"Yun-I Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Chang","raw_affiliation_strings":["Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Protein Therapeutics, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010544871","display_name":"X Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Zhang","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042590198","display_name":"Dean P. Wilkie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Wilkie","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079400267","display_name":"Amy L. Burd","orcid":"https://orcid.org/0000-0002-9625-2813","observed_orcids":["https://orcid.org/0000-0002-9625-2813"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Burd","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078276789","display_name":"Hong Shi","orcid":"https://orcid.org/0000-0002-0926-9183","observed_orcids":["https://orcid.org/0000-0002-0926-9183"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Shi","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047700528","display_name":"Sandy Rocks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Rocks","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006809501","display_name":"Richard W. Gedrich","orcid":"https://orcid.org/0009-0007-9623-0175","observed_orcids":["https://orcid.org/0009-0007-9623-0175"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Gedrich","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042204166","display_name":"Laura Abriola","orcid":"https://orcid.org/0000-0002-7304-6531","observed_orcids":["https://orcid.org/0000-0002-7304-6531"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Abriola","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074828947","display_name":"Hema H. Vasavada","orcid":"https://orcid.org/0000-0002-7258-3140","observed_orcids":["https://orcid.org/0000-0002-7258-3140"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Vasavada","raw_affiliation_strings":["Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Research Technologies, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022430976","display_name":"Mark John Lynch","orcid":"https://orcid.org/0000-0002-8476-4854","observed_orcids":["https://orcid.org/0000-0002-8476-4854"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Lynch","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Dumas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Dumas","raw_affiliation_strings":["Department of Chemistry Research, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Chemistry Research, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Research, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry Research, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058577237","display_name":"Pamela A. Trail","orcid":"https://orcid.org/0009-0006-2551-793X","observed_orcids":["https://orcid.org/0009-0006-2551-793X"]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Trail","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109668462","display_name":"S M Wilhelm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150569930","display_name":"Bayer (United States)","ror":"https://ror.org/034ffbg36","country_code":"US","type":"company","lineage":["https://openalex.org/I150569930","https://openalex.org/I67348948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Wilhelm","raw_affiliation_strings":["Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, CT, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Cancer Biology, Bayer Pharmaceuticals Corporation, West Haven, USA","institution_ids":["https://openalex.org/I150569930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055000089"],"corresponding_institution_ids":["https://openalex.org/I150569930"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":7.6557,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.97500893,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"21","issue":"3","first_page":"439","last_page":"445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":1.0},{"id":"https://openalex.org/keywords/flt3","display_name":"FLT3","score":0.8309999704360962},{"id":"https://openalex.org/keywords/internal-tandem-duplication","display_name":"internal tandem duplication","score":0.9359999895095825},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/flt3-signaling","display_name":"FLT3 signaling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mv4-11-cells","display_name":"MV4-11 cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/eol-1-cells","display_name":"EoL-1 cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9588984847068787},{"id":"https://openalex.org/C2910954276","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"Fms-Like Tyrosine Kinase 3","level":4,"score":0.7529259324073792},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6180282831192017},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5489485859870911},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5091568827629089},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4507572054862976},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.4498823285102844},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4389207065105438},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4382552206516266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837915062904358},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36699751019477844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36204224824905396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33999282121658325},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2502337098121643},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18678125739097595},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12074863910675049},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12061944603919983},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.09604659676551819},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09436526894569397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001557","descriptor_name":"Benzenesulfonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.leu.2404508","doi":"https://doi.org/10.1038/sj.leu.2404508","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.leu.2404508","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:17205056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17205056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W19734691","https://openalex.org/W1592701464","https://openalex.org/W1894322179","https://openalex.org/W1963592300","https://openalex.org/W1965694831","https://openalex.org/W1969130273","https://openalex.org/W1980829846","https://openalex.org/W1993099484","https://openalex.org/W2009069027","https://openalex.org/W2014582878","https://openalex.org/W2014595378","https://openalex.org/W2026796391","https://openalex.org/W2036049148","https://openalex.org/W2039672282","https://openalex.org/W2040322688","https://openalex.org/W2043692783","https://openalex.org/W2057676487","https://openalex.org/W2063512315","https://openalex.org/W2071612423","https://openalex.org/W2078838422","https://openalex.org/W2090045594","https://openalex.org/W2094520541","https://openalex.org/W2096340973","https://openalex.org/W2112641034","https://openalex.org/W2125676392","https://openalex.org/W2139836387","https://openalex.org/W2140765540","https://openalex.org/W2165392081","https://openalex.org/W2204503505"],"related_works":["https://openalex.org/W2580538314","https://openalex.org/W2152214606","https://openalex.org/W1559155312","https://openalex.org/W2024162263","https://openalex.org/W2523629295","https://openalex.org/W2560127522","https://openalex.org/W2112310108","https://openalex.org/W2609090402","https://openalex.org/W6921565126","https://openalex.org/W2529155113"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}