{"id":"https://openalex.org/W1982149653","doi":"https://doi.org/10.3109/08923979209009229","title":"Significant Anti-HIV Activity of New Modified Poly Anionic Polymersin vitro","display_name":"Significant Anti-HIV Activity of New Modified Poly Anionic Polymersin vitro","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1982149653","doi":"https://doi.org/10.3109/08923979209009229","mag":"1982149653","pmid":"https://pubmed.ncbi.nlm.nih.gov/1294618"},"language":"en","primary_location":{"id":"doi:10.3109/08923979209009229","doi":"https://doi.org/10.3109/08923979209009229","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979209009229","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088134754","display_name":"Robert W. Buckheit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Buckheit","raw_affiliation_strings":["Southern Research Institute, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, Alabama","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113764335","display_name":"E. Lucile White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Lucile White","raw_affiliation_strings":["Southern Research Institute, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027623984","display_name":"William M. Shannon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Shannon","raw_affiliation_strings":["Southern Research Institute, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Research Institute, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Guerrero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Guerrero","raw_affiliation_strings":["Andromaco Laboratories, S.A, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andromaco Laboratories, S.A, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003830776","display_name":"Juan Pablo Pivel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.P. Pivel","raw_affiliation_strings":["Andromaco Laboratories, S.A, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andromaco Laboratories, S.A, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011345655","display_name":"Luis Carrasco","orcid":"https://orcid.org/0000-0003-3833-8835","observed_orcids":["https://orcid.org/0000-0003-3833-8835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Carrasco","raw_affiliation_strings":["Centro De Biologia Molecular, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro De Biologia Molecular, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071691642","display_name":"Juan Antonio Leal","orcid":"https://orcid.org/0000-0002-1398-0920","observed_orcids":["https://orcid.org/0000-0002-1398-0920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.A. Leal","raw_affiliation_strings":["Centro De Investigaciones Biologicas, Madrid, Spain","Centro de investigaciones Biol\u00f3gicas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro De Investigaciones Biologicas, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"Centro de investigaciones Biol\u00f3gicas, Madrid, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110138494","display_name":"Michael A. Chirigos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801122164","display_name":"United States Army Medical Research Institute of Infectious Diseases","ror":"https://ror.org/01pveve47","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2801122164","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Chirigos","raw_affiliation_strings":["U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I2801122164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3631,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62842422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"4","first_page":"707","last_page":"721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyanionic-polymers","display_name":"polyanionic polymers","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-hiv-activity","display_name":"anti-HIV activity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase-inhibition","display_name":"HIV-1 reverse transcriptase inhibition","score":0.953000009059906},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/cytopathic-effect-inhibition","display_name":"cytopathic effect inhibition","score":0.906000018119812},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.7149999737739563},{"id":"https://openalex.org/keywords/selectivity-index","display_name":"selectivity index","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ccrf-cem-cells","display_name":"CCRF-CEM cells","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.6675818562507629},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6528269648551941},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5773294568061829},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5764032006263733},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5509325265884399},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47695720195770264},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.47427210211753845},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44684213399887085},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4419775903224945},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4416915774345398},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.41434240341186523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40390732884407043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3465730547904968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07560306787490845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000838","descriptor_name":"Anions","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015498","descriptor_name":"HIV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08923979209009229","doi":"https://doi.org/10.3109/08923979209009229","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08923979209009229","pdf_url":null,"source":{"id":"https://openalex.org/S16829457","display_name":"Immunopharmacology and Immunotoxicology","issn_l":"0892-3973","issn":["0892-3973","1532-2513"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and Immunotoxicology","raw_type":"journal-article"},{"id":"pmid:1294618","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1294618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunopharmacology and immunotoxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7857748505","display_name":"DRUG DISCOVERY GROUP FOR THE TREATMENT OF AIDS","funder_award_id":"7u01ai025617-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G984047426","display_name":null,"funder_award_id":"5UO1-AI25617","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321043","display_name":"Centro para el Desarrollo Tecnol\u00f3gico Industrial","ror":"https://ror.org/0124x7055"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1888137339","https://openalex.org/W1968873679","https://openalex.org/W1977282539","https://openalex.org/W1983732112","https://openalex.org/W1985881197","https://openalex.org/W2010546503","https://openalex.org/W2012995089","https://openalex.org/W2028136402","https://openalex.org/W2028143521","https://openalex.org/W2030484172","https://openalex.org/W2040047403","https://openalex.org/W2042695720","https://openalex.org/W2055705838","https://openalex.org/W2055859544","https://openalex.org/W2056686421","https://openalex.org/W2067786897","https://openalex.org/W2071313281","https://openalex.org/W2086462809","https://openalex.org/W2102973576","https://openalex.org/W2104378500","https://openalex.org/W2124217674","https://openalex.org/W2143773220","https://openalex.org/W2143788821","https://openalex.org/W2333399282","https://openalex.org/W2463651875","https://openalex.org/W4237110073","https://openalex.org/W4256221661"],"related_works":["https://openalex.org/W1993108203","https://openalex.org/W2014909299","https://openalex.org/W2324795081","https://openalex.org/W1968181005","https://openalex.org/W2047840729","https://openalex.org/W1988839199","https://openalex.org/W2072598859","https://openalex.org/W2086071972","https://openalex.org/W2015623520","https://openalex.org/W2013923534"],"abstract_inverted_index":{"The":[0],"anti-HIV":[1],"activities":[2],"of":[3,62,94,104,110,127,130,155,194],"two":[4,117],"new":[5],"polyanionic":[6,119],"polymers":[7,120],"(AM":[8],"242":[9,55,100],"and":[10,18,30,37,56,64,91,133],"AM":[11,54,57,99,111,163],"612)":[12],"were":[13,121,134,142],"investigated":[14],"in":[15,96,123,183,192],"cell":[16,74],"culture-based":[17],"biochemical":[19],"antiviral":[20,149],"assays.":[21],"These":[22,116],"compounds":[23,80,141,178],"inhibited":[24,82],"the":[25,47,50,68,84,92,125,140,189],"reverse":[26,70],"transcriptases":[27],"from":[28,35,171],"HIV-1":[29,69,89,131],"HIV-2,":[31],"using":[32],"enzyme":[33],"purified":[34],"virions":[36],"either":[38],"a":[39,128,152,159,180],"ribosomal":[40,51],"RNA":[41,52],"or":[42],"gapped":[43],"duplex":[44],"DNA":[45],"as":[46,186],"template.":[48],"With":[49],"template,":[53],"612":[58,112,164],"had":[59,101,148],"ID50":[60],"values":[61],"1.1":[63],"0.10":[65],"micrograms/ml":[66],"against":[67,137],"transcriptase.":[71],"In":[72],"vitro":[73],"based":[75],"assays":[76],"determined":[77,187],"that":[78,109],"both":[79,83],"significantly":[81],"cytopathic":[85],"effects":[86],"associated":[87],"with":[88],"infection":[90],"replication":[93],"virus":[95],"infected":[97],"cells.":[98],"an":[102],"IC50":[103],"approximately":[105],"1.0":[106],"micrograms/ml,":[107],"while":[108],"was":[113,165],"0.19":[114],"micrograms/ml.":[115],"active":[118,136],"effective":[122],"inhibiting":[124],"growth":[126],"panel":[129],"isolates":[132],"also":[135],"HIV-2.":[138],"Although":[139],"toxic":[143],"at":[144],"high":[145,160],"concentration,":[146],"they":[147],"activity":[150],"over":[151],"wide":[153],"range":[154],"nontoxic":[156],"concentrations,":[157],"yielding":[158],"selectivity":[161],"index.":[162],"100%":[166],"protective":[167],"for":[168],"CEM":[169],"cells":[170],"320":[172],"ng/ml":[173],"to":[174],"1":[175],"microgram/ml.":[176],"Both":[177],"caused":[179],"significant":[181],"increase":[182,191],"cellular":[184,198],"proliferation":[185],"by":[188],"concentration-dependent":[190],"incorporation":[193],"radioactive":[195],"precursors":[196],"into":[197],"macromolecules.":[199]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}