{"id":"https://openalex.org/W1982146336","doi":"https://doi.org/10.3390/nu4101399","title":"Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases","display_name":"Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases","publication_year":2012,"publication_date":"2012-10-09","ids":{"openalex":"https://openalex.org/W1982146336","doi":"https://doi.org/10.3390/nu4101399","mag":"1982146336","pmid":"https://pubmed.ncbi.nlm.nih.gov/23201762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3497002"},"language":"en","primary_location":{"id":"doi:10.3390/nu4101399","doi":"https://doi.org/10.3390/nu4101399","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu4101399","pdf_url":"https://www.mdpi.com/2072-6643/4/10/1399/pdf?version=1349784236","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1982146336"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/4/10/1399/pdf?version=1349784236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109815469","display_name":"William M. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Johnson","raw_affiliation_strings":["Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA","Louis B. Stokes Veterans Affairs Medical Research Center, 10701 East Blvd, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis B. Stokes Veterans Affairs Medical Research Center, 10701 East Blvd, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I4210110978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024969726","display_name":"Amy L. Wilson\u2010Delfosse","orcid":"https://orcid.org/0000-0002-3427-2202","observed_orcids":["https://orcid.org/0000-0002-3427-2202"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L. Wilson-Delfosse","raw_affiliation_strings":["Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057571027","display_name":"John J. Mieyal","orcid":"https://orcid.org/0000-0002-8957-6334","observed_orcids":["https://orcid.org/0000-0002-8957-6334"]},"institutions":[{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John. J. Mieyal","raw_affiliation_strings":["Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA","Louis B. Stokes Veterans Affairs Medical Research Center, 10701 East Blvd, Cleveland, OH 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Louis B. Stokes Veterans Affairs Medical Research Center, 10701 East Blvd, Cleveland, OH 44106, USA","institution_ids":["https://openalex.org/I4210110978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057571027"],"corresponding_institution_ids":["https://openalex.org/I4210110978","https://openalex.org/I58956616"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.8736,"has_fulltext":true,"cited_by_count":369,"citation_normalized_percentile":{"value":0.87538941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"10","first_page":"1399","last_page":"1440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.8363999724388123,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-homeostasis","display_name":"glutathione homeostasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glutathione-dependent-enzymes","display_name":"glutathione-dependent enzymes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7639999985694885},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutathione-redox-status","display_name":"glutathione redox state","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/friedreich-ataxia","display_name":"Friedreich's ataxia","score":1.0},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glutathione-supplementation","display_name":"glutathione supplementation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8266443014144897},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5765168070793152},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.41777920722961426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3992346525192261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3808552026748657},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32843077182769775},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.322593092918396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24036601185798645},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17286086082458496}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005621","descriptor_name":"Friedreich Ataxia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005621","descriptor_name":"Friedreich Ataxia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005621","descriptor_name":"Friedreich Ataxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/nu4101399","doi":"https://doi.org/10.3390/nu4101399","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu4101399","pdf_url":"https://www.mdpi.com/2072-6643/4/10/1399/pdf?version=1349784236","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmid:23201762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23201762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3497002","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3497002/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.662.1031","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.662.1031","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497002/pdf/nutrients-04-01399.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/nu4101399","doi":"https://doi.org/10.3390/nu4101399","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu4101399","pdf_url":"https://www.mdpi.com/2072-6643/4/10/1399/pdf?version=1349784236","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4291216142","display_name":null,"funder_award_id":"1 I01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4581199257","display_name":"Pre-doctoral Training Program in Molecular Therapeutics","funder_award_id":"T32GM008803","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5777729140","display_name":null,"funder_award_id":"BX000290","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6481762622","display_name":null,"funder_award_id":"NIH R21 5R21NS073170-02","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8303586937","display_name":"Assay Development and Discovery of LRRK2 Inhibitors for Parkinson Disease","funder_award_id":"R21NS073170","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G978195918","display_name":null,"funder_award_id":"I01 BX000290","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1982146336.pdf","grobid_xml":"https://content.openalex.org/works/W1982146336.grobid-xml"},"referenced_works_count":198,"referenced_works":["https://openalex.org/W6900530","https://openalex.org/W1481060574","https://openalex.org/W1487440368","https://openalex.org/W1488271004","https://openalex.org/W1506236230","https://openalex.org/W1507330027","https://openalex.org/W1546982963","https://openalex.org/W1558795362","https://openalex.org/W1563653502","https://openalex.org/W1592407422","https://openalex.org/W1614519645","https://openalex.org/W1619037645","https://openalex.org/W1686360944","https://openalex.org/W1791420399","https://openalex.org/W1955012509","https://openalex.org/W1955466454","https://openalex.org/W1963882244","https://openalex.org/W1965437737","https://openalex.org/W1966389910","https://openalex.org/W1966773864","https://openalex.org/W1966787519","https://openalex.org/W1968060296","https://openalex.org/W1969023471","https://openalex.org/W1969502837","https://openalex.org/W1970034280","https://openalex.org/W1970292153","https://openalex.org/W1973585637","https://openalex.org/W1974724055","https://openalex.org/W1975218333","https://openalex.org/W1975835742","https://openalex.org/W1976375430","https://openalex.org/W1977603207","https://openalex.org/W1977642609","https://openalex.org/W1978651752","https://openalex.org/W1978895733","https://openalex.org/W1979179771","https://openalex.org/W1980724182","https://openalex.org/W1980763729","https://openalex.org/W1983011376","https://openalex.org/W1983191290","https://openalex.org/W1983480912","https://openalex.org/W1984502108","https://openalex.org/W1984940419","https://openalex.org/W1985730402","https://openalex.org/W1986079532","https://openalex.org/W1986384924","https://openalex.org/W1986790448","https://openalex.org/W1989383588","https://openalex.org/W1991334367","https://openalex.org/W1991628500","https://openalex.org/W1992037022","https://openalex.org/W1994833789","https://openalex.org/W1997170069","https://openalex.org/W1997727568","https://openalex.org/W1998115852","https://openalex.org/W2000388690","https://openalex.org/W2000550411","https://openalex.org/W2001113682","https://openalex.org/W2001611600","https://openalex.org/W2002979560","https://openalex.org/W2005248412","https://openalex.org/W2005508231","https://openalex.org/W2007628284","https://openalex.org/W2009304280","https://openalex.org/W2010131630","https://openalex.org/W2010432323","https://openalex.org/W2010712769","https://openalex.org/W2011007124","https://openalex.org/W2012161646","https://openalex.org/W2012275421","https://openalex.org/W2012851706","https://openalex.org/W2013135033","https://openalex.org/W2014504691","https://openalex.org/W2014837633","https://openalex.org/W2017122609","https://openalex.org/W2019314795","https://openalex.org/W2019315395","https://openalex.org/W2019389880","https://openalex.org/W2021477435","https://openalex.org/W2022367303","https://openalex.org/W2022446189","https://openalex.org/W2022502344","https://openalex.org/W2022642951","https://openalex.org/W2022851867","https://openalex.org/W2025597034","https://openalex.org/W2025785072","https://openalex.org/W2028491651","https://openalex.org/W2029288288","https://openalex.org/W2031426766","https://openalex.org/W2031763914","https://openalex.org/W2032253254","https://openalex.org/W2032350023","https://openalex.org/W2032393807","https://openalex.org/W2033243993","https://openalex.org/W2034703968","https://openalex.org/W2034845317","https://openalex.org/W2036810172","https://openalex.org/W2039018005","https://openalex.org/W2040250889","https://openalex.org/W2042549443","https://openalex.org/W2042895845","https://openalex.org/W2043583473","https://openalex.org/W2044695362","https://openalex.org/W2045438724","https://openalex.org/W2049225057","https://openalex.org/W2050578486","https://openalex.org/W2050994990","https://openalex.org/W2051856314","https://openalex.org/W2053040219","https://openalex.org/W2055072764","https://openalex.org/W2055985540","https://openalex.org/W2056123940","https://openalex.org/W2057049100","https://openalex.org/W2057312726","https://openalex.org/W2059700478","https://openalex.org/W2062217279","https://openalex.org/W2062279793","https://openalex.org/W2062609826","https://openalex.org/W2062682951","https://openalex.org/W2062745650","https://openalex.org/W2062760011","https://openalex.org/W2065880264","https://openalex.org/W2065993125","https://openalex.org/W2066762007","https://openalex.org/W2067007754","https://openalex.org/W2069124726","https://openalex.org/W2069245014","https://openalex.org/W2069926262","https://openalex.org/W2071214407","https://openalex.org/W2071492626","https://openalex.org/W2073446096","https://openalex.org/W2073489896","https://openalex.org/W2073995490","https://openalex.org/W2075154209","https://openalex.org/W2075793841","https://openalex.org/W2076531205","https://openalex.org/W2077633497","https://openalex.org/W2078145461","https://openalex.org/W2081792021","https://openalex.org/W2084199428","https://openalex.org/W2084485820","https://openalex.org/W2084878154","https://openalex.org/W2085128107","https://openalex.org/W2087514755","https://openalex.org/W2088446635","https://openalex.org/W2088750246","https://openalex.org/W2089032508","https://openalex.org/W2089755573","https://openalex.org/W2090406179","https://openalex.org/W2090825344","https://openalex.org/W2090971266","https://openalex.org/W2090986135","https://openalex.org/W2092621535","https://openalex.org/W2093444367","https://openalex.org/W2093700893","https://openalex.org/W2095000147","https://openalex.org/W2095574453","https://openalex.org/W2099207242","https://openalex.org/W2099793152","https://openalex.org/W2100664594","https://openalex.org/W2101573004","https://openalex.org/W2102560718","https://openalex.org/W2102866245","https://openalex.org/W2103564268","https://openalex.org/W2103964183","https://openalex.org/W2107768418","https://openalex.org/W2107882830","https://openalex.org/W2117503265","https://openalex.org/W2121515004","https://openalex.org/W2131919458","https://openalex.org/W2133562348","https://openalex.org/W2137508090","https://openalex.org/W2139093498","https://openalex.org/W2143268562","https://openalex.org/W2143372650","https://openalex.org/W2146774140","https://openalex.org/W2148589294","https://openalex.org/W2149686541","https://openalex.org/W2150821575","https://openalex.org/W2151387909","https://openalex.org/W2152975037","https://openalex.org/W2154653277","https://openalex.org/W2156494900","https://openalex.org/W2159586517","https://openalex.org/W2161177768","https://openalex.org/W2164036989","https://openalex.org/W2164613024","https://openalex.org/W2164919571","https://openalex.org/W2165492152","https://openalex.org/W2166337262","https://openalex.org/W2167424396","https://openalex.org/W2168709353","https://openalex.org/W2169258488","https://openalex.org/W2169714384","https://openalex.org/W2184733840","https://openalex.org/W2280348805","https://openalex.org/W2302439822","https://openalex.org/W2336510845"],"related_works":["https://openalex.org/W2059700478","https://openalex.org/W2144361706","https://openalex.org/W1989005513","https://openalex.org/W2778222985","https://openalex.org/W4211037249","https://openalex.org/W7203862861","https://openalex.org/W2332562424","https://openalex.org/W2027591882","https://openalex.org/W3021009631"],"abstract_inverted_index":{"Dysregulation":[0],"of":[1,18,46,65,76,86,103,122,126,128,140,173,175,191],"glutathione":[2,66,115,129,178,193],"homeostasis":[3],"and":[4,16,24,30,44,70,72,84,96,151,171],"alterations":[5],"in":[6,13,67,114,119,138,145],"glutathione-dependent":[7,78,123,131],"enzyme":[8],"activities":[9,121],"are":[10,89,107,110,133,136,149,157,197],"increasingly":[11],"implicated":[12,137],"the":[14,40,52,60,74,120,188],"induction":[15],"progression":[17,85],"neurodegenerative":[19,87,142,183],"diseases,":[20,26,184],"including":[21,91],"Alzheimer's,":[22],"Parkinson's":[23],"Huntington's":[25],"amyotrophic":[27],"lateral":[28],"sclerosis,":[29],"Friedreich's":[31],"ataxia.":[32],"In":[33,99],"this":[34],"review":[35],"background":[36],"is":[37,57],"provided":[38],"on":[39,51,59,73],"steady-state":[41],"synthesis,":[42],"regulation,":[43],"transport":[45],"glutathione,":[47],"with":[48,159],"primary":[49],"focus":[50],"brain.":[53],"A":[54],"brief":[55],"overview":[56],"presented":[58],"distinct":[61],"but":[62],"vital":[63],"roles":[64],"cellular":[68],"maintenance":[69],"survival,":[71],"functions":[75],"key":[77,104],"enzymes.":[79,124],"Major":[80],"contributors":[81],"to":[82,112,162],"initiation":[83],"diseases":[88],"considered,":[90],"oxidative":[92],"stress,":[93],"protein":[94,97],"misfolding,":[95],"aggregation.":[98],"each":[100,141],"case":[101],"examples":[102],"regulatory":[105],"mechanisms":[106],"identified":[108],"that":[109,135],"sensitive":[111],"changes":[113],"redox":[116],"status":[117],"and/or":[118,130],"Mechanisms":[125],"dysregulation":[127],"enzymes":[132],"discussed":[134],"pathogenesis":[139],"disease.":[143],"Limitations":[144],"information":[146],"or":[147,177],"interpretation":[148],"identified,":[150],"possible":[152],"avenues":[153],"for":[154,166,182],"further":[155],"research":[156],"described":[158],"an":[160],"aim":[161],"elucidating":[163],"novel":[164],"targets":[165],"therapeutic":[167,180],"interventions.":[168],"The":[169],"pros":[170],"cons":[172],"administration":[174],"N-acetylcysteine":[176],"as":[179,185,187,194],"agents":[181],"well":[186],"potential":[189],"utility":[190],"serum":[192],"a":[195],"biomarker,":[196],"critically":[198],"evaluated.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":35},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":37},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":15}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
