{"id":"https://openalex.org/W1982134384","doi":"https://doi.org/10.1016/j.bmcl.2010.03.062","title":"Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)","display_name":"Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a)","publication_year":2010,"publication_date":"2010-03-22","ids":{"openalex":"https://openalex.org/W1982134384","doi":"https://doi.org/10.1016/j.bmcl.2010.03.062","mag":"1982134384","pmid":"https://pubmed.ncbi.nlm.nih.gov/20363624"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2010.03.062","doi":"https://doi.org/10.1016/j.bmcl.2010.03.062","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2010.03.062","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012787251","display_name":"P. Douglas Boatman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. Douglas Boatman","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. dboatman@arenapharm.com","Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA. dboatman@arenapharm.com","institution_ids":["https://openalex.org/I4210126734"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038694596","display_name":"Thomas O. Schrader","orcid":"https://orcid.org/0000-0003-3468-9566","observed_orcids":["https://orcid.org/0000-0003-3468-9566"]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas O. Schrader","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087450802","display_name":"Michelle Kasem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Kasem","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077608975","display_name":"Benjamin R. G. Johnson","orcid":"https://orcid.org/0000-0001-9715-1160","observed_orcids":["https://orcid.org/0000-0001-9715-1160"]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin R. Johnson","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094888","display_name":"Philip J. Skinner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Skinner","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440988","display_name":"Jae\u2010Kyu Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae-Kyu Jung","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045070588","display_name":"Jerry Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Xu","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036643789","display_name":"Martin C. Cherrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin C. Cherrier","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015658574","display_name":"Peter J. Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Webb","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016296935","display_name":"Graeme Semple","orcid":"https://orcid.org/0000-0002-9666-1588","observed_orcids":["https://orcid.org/0000-0002-9666-1588"]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graeme Semple","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061236885","display_name":"Carleton R. Sage","orcid":"https://orcid.org/0009-0008-6270-1861","observed_orcids":["https://orcid.org/0009-0008-6270-1861"]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carleton R. Sage","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jens Knudsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jens Knudsen","raw_affiliation_strings":["Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060964279","display_name":"Ruoping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruoping Chen","raw_affiliation_strings":["Department of Discovery Biology, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Discovery Biology, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041133825","display_name":"Andrew K.P. Taggart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew K. Taggart","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026400631","display_name":"Ester Carballo\u2010Jane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ester Carballo-Jane","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110484231","display_name":"Jeremy G. Richman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy G. Richman","raw_affiliation_strings":["Department of Discovery Biology, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Discovery Biology, Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012787251"],"corresponding_institution_ids":["https://openalex.org/I4210126734"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":2.2181,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.862185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"20","issue":"9","first_page":"2797","last_page":"2800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13265","display_name":"Synthesis of Tetrazole Derivatives","score":0.2013999968767166,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.11020000278949738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr109a","display_name":"GPR109A","score":0.949999988079071},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.9610000252723694},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.47099998593330383},{"id":"https://openalex.org/keywords/structure-activity-optimization","display_name":"structure-activity optimization","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9447044730186462},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.9072802662849426},{"id":"https://openalex.org/C2780092750","wikidata":"https://www.wikidata.org/wiki/Q134658","display_name":"Niacin","level":2,"score":0.6931663751602173},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.6906077861785889},{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.6729347705841064},{"id":"https://openalex.org/C2780827033","wikidata":"https://www.wikidata.org/wiki/Q58826308","display_name":"Tetrazole","level":2,"score":0.5655502080917358},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5623760223388672},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5336943864822388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.530193030834198},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.48331451416015625},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4795253276824951},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44458338618278503},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41624295711517334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2682619094848633},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013777","descriptor_name":"Tetrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2010.03.062","doi":"https://doi.org/10.1016/j.bmcl.2010.03.062","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2010.03.062","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:20363624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20363624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1481564277","https://openalex.org/W1976763856","https://openalex.org/W1985018554","https://openalex.org/W1996819821","https://openalex.org/W2004243328","https://openalex.org/W2032787297","https://openalex.org/W2041220660","https://openalex.org/W2046991199","https://openalex.org/W2048148906","https://openalex.org/W2064216426","https://openalex.org/W2076090516","https://openalex.org/W2081511316","https://openalex.org/W2089505657","https://openalex.org/W2103682415","https://openalex.org/W2115572248","https://openalex.org/W2130877850","https://openalex.org/W2136868680","https://openalex.org/W2321715201"],"related_works":["https://openalex.org/W2005531594","https://openalex.org/W2051427616","https://openalex.org/W2002879327","https://openalex.org/W2157853483","https://openalex.org/W2071911442","https://openalex.org/W2037637780","https://openalex.org/W3011665061","https://openalex.org/W2080754366","https://openalex.org/W1992812460","https://openalex.org/W1982384322"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}