{"id":"https://openalex.org/W1982106345","doi":"https://doi.org/10.1002/chin.199134306","title":"ChemInform Abstract: Design, Synthesis, and Studies on the Structure Activity Relationships of Certain Pyrrolo(2,3\u2010d)pyrimidine Nucleosides and Structurally Related Analogs as Potential Antineoplastic and Antiviral Agents.","display_name":"ChemInform Abstract: Design, Synthesis, and Studies on the Structure Activity Relationships of Certain Pyrrolo(2,3\u2010d)pyrimidine Nucleosides and Structurally Related Analogs as Potential Antineoplastic and Antiviral Agents.","publication_year":1991,"publication_date":"1991-08-27","ids":{"openalex":"https://openalex.org/W1982106345","doi":"https://doi.org/10.1002/chin.199134306","mag":"1982106345"},"language":"en","primary_location":{"id":"doi:10.1002/chin.199134306","doi":"https://doi.org/10.1002/chin.199134306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.199134306","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020052126","display_name":"Leroy B. Townsend","orcid":"https://orcid.org/0000-0002-2436-0575","observed_orcids":["https://orcid.org/0000-0002-2436-0575"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. B. TOWNSEND","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. DRACH","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064750495","display_name":"Linda L. Wotring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. L. WOTRING","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001624900","display_name":"Sauro Vittori","orcid":"https://orcid.org/0000-0003-2572-2862","observed_orcids":["https://orcid.org/0000-0003-2572-2862"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. VITTORI","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020481610","display_name":"Jeffrey S. Pudlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. S. PUDLO","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009098620","display_name":"Eric E. Swayze","orcid":"https://orcid.org/0000-0001-6430-6576","observed_orcids":["https://orcid.org/0000-0001-6430-6576"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. E. SWAYZE","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103212759","display_name":"P. K. GUPTA","orcid":"https://orcid.org/0000-0003-4424-1810","observed_orcids":["https://orcid.org/0000-0003-4424-1810"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. GUPTA","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112760356","display_name":"T. MARUYAMA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. MARUYAMA","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033234839","display_name":"Naveen K. Saxena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. SAXENA","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109228371","display_name":"L. A. COLEMAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. A. COLEMAN","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009486603","display_name":"Allison C. Westerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. C. WESTERMAN","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072129825","display_name":"J. J. SPURR","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. J. SPURR","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. R. NASSIRI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. R. NASSIRI","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112443640","display_name":"Steven R. Turk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. R. TURK","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103519753","display_name":"Steven H. Krawczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. H. KRAWCZYK","raw_affiliation_strings":["Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dep. Med. Chem. Pharm. Chem., Coll. Pharm., Univ. Michigan, Ann Arbor, MI 48109-1065, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07500914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"22","issue":"34","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.42899999022483826,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3483999967575073,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9150000214576721},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":1.0},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.9459999799728394},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9274938106536865},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.7912052273750305},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.583885908126831},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5609989762306213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/chin.199134306","doi":"https://doi.org/10.1002/chin.199134306","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chin.199134306","pdf_url":null,"source":{"id":"https://openalex.org/S41354064","display_name":"ChemInform","issn_l":"0009-2975","issn":["0009-2975","0931-7597","1431-5890","1522-2667","2199-2924"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemInform","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2949899324"],"related_works":["https://openalex.org/W2949899324","https://openalex.org/W2046221502","https://openalex.org/W2950072250","https://openalex.org/W2053651371","https://openalex.org/W7037047086","https://openalex.org/W2084057475","https://openalex.org/W1966124583","https://openalex.org/W2950482056","https://openalex.org/W2953246897","https://openalex.org/W2950466314"],"abstract_inverted_index":{"Abstract":[0,25],"ChemInform":[1,24],"is":[2,42],"a":[3,11,23,35],"weekly":[4],"Abstracting":[5],"Service,":[6],"delivering":[7],"concise":[8],"information":[9],"at":[10],"glance":[12],"that":[13],"was":[14,30],"extracted":[15],"from":[16],"about":[17],"100":[18],"leading":[19],"journals.":[20],"To":[21],"access":[22],"of":[26],"an":[27],"article":[28,41],"which":[29],"published":[31],"elsewhere,":[32],"please":[33],"select":[34],"\u201cFull":[36],"Text\u201d":[37],"option.":[38,47],"The":[39],"original":[40],"trackable":[43],"via":[44],"the":[45],"\u201cReferences\u201d":[46]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}