{"id":"https://openalex.org/W198207299","doi":"https://doi.org/10.1096/fasebj.21.5.a246-c","title":"Up\u2010regulation of Dopamine Receptors by Cigarette Smoke Exposure","display_name":"Up\u2010regulation of Dopamine Receptors by Cigarette Smoke Exposure","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W198207299","doi":"https://doi.org/10.1096/fasebj.21.5.a246-c","mag":"198207299"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a246-c","doi":"https://doi.org/10.1096/fasebj.21.5.a246-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a246-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112657976","display_name":"Leah Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah R. Miller","raw_affiliation_strings":["Department of Biomedical Sciences Meharry Medical College Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences Meharry Medical College Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112520459","display_name":"Shyamali Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyamali Mukherjee","raw_affiliation_strings":["Department of Biomedical Sciences Meharry Medical College Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences Meharry Medical College Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103404831","display_name":"Salil K. Das","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salil K. Das","raw_affiliation_strings":["Department of Biomedical Sciences Meharry Medical College Nashville TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences Meharry Medical College Nashville TN 37208","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I118073183"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03177197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.3546999990940094,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.7789999842643738},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":1.0},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.949999988079071},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.8519999980926514},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.3059999942779541},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.7279999852180481},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.8119999766349792},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7839999794960022},{"id":"https://openalex.org/keywords/brain-cancer","display_name":"brain cancer","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7487967014312744},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.611392617225647},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5988426804542542},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5568154454231262},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5545766949653625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4680003523826599},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.43266257643699646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3994990885257721},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38689398765563965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3154817819595337},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0682203471660614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06604376435279846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a246-c","doi":"https://doi.org/10.1096/fasebj.21.5.a246-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a246-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8899999856948853,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983708416","https://openalex.org/W2282163227","https://openalex.org/W2063575500","https://openalex.org/W2084451501","https://openalex.org/W2096222205","https://openalex.org/W2019218338","https://openalex.org/W124390504","https://openalex.org/W1501793834","https://openalex.org/W2046815817","https://openalex.org/W2026718617"],"abstract_inverted_index":{"Cigarette":[0],"smoking":[1,111,197],"has":[2,19,31,77,112],"been":[3,79],"implicated":[4],"in":[5,59,82,102,124,168,176,187,203],"chronic":[6],"obstructive":[7],"pulmonary":[8],"diseases,":[9],"cardiovascular":[10],"disease,":[11,39],"and":[12,75,121,152,160,189,212],"brain":[13,24,50,61,148,205],"cancer.":[14,51],"However,":[15],"cigarette":[16,110,196],"smoke":[17,136],"(CS)":[18],"a":[20,32,46,103],"controversial":[21],"effect":[22,34,64,93,115],"on":[23,35,67,97,116],"function.":[25,62],"Epidemiological":[26],"studies":[27,42],"suggest":[28],"that":[29,109,195],"CS":[30,44,66,95],"beneficial":[33],"patients":[36],"with":[37],"Parkinson's":[38],"whereas":[40],"animal":[41,84],"implicate":[43],"as":[45],"major":[47],"cause":[48],"of":[49,65,70,94,119,172],"The":[52,63,147,180],"dopaminergic":[53,99,200],"system":[54,101],"plays":[55],"an":[56,83,113,166,185],"important":[57],"role":[58],"overall":[60],"the":[68,87,92,98,117,125,169,177,199,204,208],"expression":[69,118,211],"dopamine":[71],"(DA)":[72],"receptors":[73,123,154],"(D1":[74],"D2)":[76],"not":[78],"fully":[80],"elucidated":[81],"model.":[85,106],"In":[86],"present":[88],"study":[89],"we":[90],"examined":[91],"exposure":[96],"neuron":[100,201],"guinea":[104,128],"pig":[105],"We":[107,193],"hypothesized":[108],"excitatory":[114],"D1":[120,173,188],"D2":[122,190],"brain.":[126],"Three\u2010week\u2010old":[127],"pigs":[129],"were":[130,155],"subjected":[131],"to":[132],"mainstream":[133],"or":[134],"sham":[135],"exposure,":[137],"generated":[138],"twice":[139],"daily":[140],"from":[141],"three":[142],"cigarettes":[143],"for":[144],"6":[145],"weeks.":[146],"tissue":[149],"was":[150,165],"collected":[151],"DA":[153,209],"analyzed":[156],"by":[157,206,215],"Western":[158,181],"blot":[159,182],"ligand":[161],"binding":[162,170],"assay.":[163],"There":[164],"increase":[167,186],"capacity":[171],"receptor":[174,210],"only":[175],"midbrain":[178],"region.":[179],"analysis":[183],"showed":[184],"protein":[191],"levels.":[192],"conclude":[194],"modifies":[198],"activity":[202],"up\u2010regulating":[207],"binding.":[213],"(Supported":[214],"Army":[216],"grant":[217],"W81XWH\u201006\u20102\u20100044)":[218]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}