{"id":"https://openalex.org/W198205171","doi":"https://doi.org/10.1017/s0317167100025129","title":"Seven Cases of Gilles de la Tourette's Syndrome: Partial Relief with Clonazepam: A Pilot Study","display_name":"Seven Cases of Gilles de la Tourette's Syndrome: Partial Relief with Clonazepam: A Pilot Study","publication_year":1977,"publication_date":"1977-11-01","ids":{"openalex":"https://openalex.org/W198205171","doi":"https://doi.org/10.1017/s0317167100025129","mag":"198205171","pmid":"https://pubmed.ncbi.nlm.nih.gov/271517"},"language":"en","primary_location":{"id":"doi:10.1017/s0317167100025129","doi":"https://doi.org/10.1017/s0317167100025129","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0317167100025129","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D687B742CFB16FE5E42778B6ECFF7AF9/S0317167100025129a.pdf/div-class-title-seven-cases-of-gilles-de-la-tourette-s-syndrome-partial-relief-with-clonazepam-a-pilot-study-div.pdf","source":{"id":"https://openalex.org/S3196323","display_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","issn_l":"0317-1671","issn":["0317-1671","2057-0155"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D687B742CFB16FE5E42778B6ECFF7AF9/S0317167100025129a.pdf/div-class-title-seven-cases-of-gilles-de-la-tourette-s-syndrome-partial-relief-with-clonazepam-a-pilot-study-div.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052071937","display_name":"Michel Gonce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Gonce","raw_affiliation_strings":["Department of Neurobiology, Clinical Research Institute of Montreal","Clinical Research Institute of Montreal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Clinical Research Institute of Montreal","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Clinical Research Institute of Montreal","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112826876","display_name":"A. Barbeau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"A. Barbeau","raw_affiliation_strings":["Department of Neurobiology, Clinical Research Institute of Montreal","Clinical Research Institute of Montreal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Clinical Research Institute of Montreal","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Clinical Research Institute of Montreal","institution_ids":["https://openalex.org/I4210158752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112826876"],"corresponding_institution_ids":["https://openalex.org/I4210158752"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":4.2219,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.92978285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"4","first_page":"279","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9829999804496765},{"id":"https://openalex.org/keywords/clonazepam","display_name":"clonazepam","score":0.9860000014305115},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tics","display_name":"tics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/myoclonia","display_name":"myoclonia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8840000033378601},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.7409999966621399},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dopamine-metabolism","display_name":"dopamine metabolism","score":0.9269999861717224},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779426884","wikidata":"https://www.wikidata.org/wiki/Q407988","display_name":"Clonazepam","level":2,"score":0.9571307897567749},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.8741153478622437},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.7636316418647766},{"id":"https://openalex.org/C2777200579","wikidata":"https://www.wikidata.org/wiki/Q738538","display_name":"Tics","level":2,"score":0.690622866153717},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4927416145801544},{"id":"https://openalex.org/C2776681478","wikidata":"https://www.wikidata.org/wiki/Q1077139","display_name":"Tic disorder","level":3,"score":0.47485044598579407},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.4722444415092468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3757726848125458},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36796313524246216},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3353918790817261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2066810131072998},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19259539246559143},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001570","descriptor_name":"Benzodiazepinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002998","descriptor_name":"Clonazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002998","descriptor_name":"Clonazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1017/s0317167100025129","doi":"https://doi.org/10.1017/s0317167100025129","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0317167100025129","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D687B742CFB16FE5E42778B6ECFF7AF9/S0317167100025129a.pdf/div-class-title-seven-cases-of-gilles-de-la-tourette-s-syndrome-partial-relief-with-clonazepam-a-pilot-study-div.pdf","source":{"id":"https://openalex.org/S3196323","display_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","issn_l":"0317-1671","issn":["0317-1671","2057-0155"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","raw_type":"journal-article"},{"id":"pmid:271517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/271517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1017/s0317167100025129","doi":"https://doi.org/10.1017/s0317167100025129","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0317167100025129","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/D687B742CFB16FE5E42778B6ECFF7AF9/S0317167100025129a.pdf/div-class-title-seven-cases-of-gilles-de-la-tourette-s-syndrome-partial-relief-with-clonazepam-a-pilot-study-div.pdf","source":{"id":"https://openalex.org/S3196323","display_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","issn_l":"0317-1671","issn":["0317-1671","2057-0155"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319983","display_name":"W. Garfield Weston Foundation","ror":"https://ror.org/0512g3q82"},{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320332679","display_name":"Parkinsonfonden","ror":"https://ror.org/0300wre24"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W198205171.pdf","grobid_xml":"https://content.openalex.org/works/W198205171.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W265243324","https://openalex.org/W1844457544","https://openalex.org/W1967731648","https://openalex.org/W1974514170","https://openalex.org/W1979566185","https://openalex.org/W1980619010","https://openalex.org/W1996392539","https://openalex.org/W1998695084","https://openalex.org/W2009480111","https://openalex.org/W2014841859","https://openalex.org/W2015704994","https://openalex.org/W2021248141","https://openalex.org/W2047133896","https://openalex.org/W2057293933","https://openalex.org/W2058681176","https://openalex.org/W2067825638","https://openalex.org/W2071663305","https://openalex.org/W2075279817","https://openalex.org/W2081385933","https://openalex.org/W2082990488","https://openalex.org/W2091571912","https://openalex.org/W2097630513","https://openalex.org/W2106158619","https://openalex.org/W2125293134","https://openalex.org/W2137085891","https://openalex.org/W2413751790","https://openalex.org/W2414340487","https://openalex.org/W2416871568","https://openalex.org/W2421287542","https://openalex.org/W2474421588","https://openalex.org/W2803907504"],"related_works":["https://openalex.org/W2077368196","https://openalex.org/W99842634","https://openalex.org/W2469723601","https://openalex.org/W2050661539","https://openalex.org/W2089540979","https://openalex.org/W2107109924","https://openalex.org/W2062334315","https://openalex.org/W4240444598","https://openalex.org/W2088550173","https://openalex.org/W6885079097"],"abstract_inverted_index":{"The":[0],"histories":[1],"of":[2,6,18,38,55,64,72,84,99,107],"seven":[3],"consecutive":[4],"cases":[5],"Gilles":[7,119],"de":[8,120],"la":[9,121],"Tourette's":[10,122],"syndrome":[11],"are":[12,51],"presented":[13],"to":[14,25,93,112],"exemplify":[15],"the":[16,30,96,105],"range":[17],"clinical":[19],"manifestations":[20],"in":[21,47,104,115,118],"this":[22,39],"disease":[23],"and":[24,46,66,78,80,101,109],"collate":[26],"preliminary":[27],"results":[28],"with":[29,43,49],"new":[31],"benzodiazepine,":[32],"clonazepam,":[33],"as":[34],"possible":[35,113],"adjuvant":[36],"therapy":[37],"disorder.":[40],"Controlled":[41],"trials":[42],"clonazepam":[44,75],"alone":[45],"association":[48],"haloperidol":[50],"now":[52],"justified.":[53],"Five":[54],"our":[56],"7":[57],"patients":[58],"had":[59],"a":[60,68],"positive":[61],"family":[62,70],"history":[63,71],"tics,":[65,108],"2":[67],"confirmed":[69],"gout.":[73],"Because":[74],"improves":[76],"myoclonia":[77],"tics":[79],"because":[81],"its":[82],"mechanism":[83],"action":[85],"possibly":[86],"involves":[87],"serotonin,":[88],"we":[89],"thought":[90],"it":[91],"worthwhile":[92],"study":[94],"simultaneously":[95],"relative":[97],"roles":[98],"serotonin":[100],"dopamine":[102],"metabolism":[103,117],"production":[106],"their":[110],"relationship":[111],"defects":[114],"purine":[116],"syndrome.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
