{"id":"https://openalex.org/W1982010446","doi":"https://doi.org/10.3987/rev-00-529","title":"4- and 5-Oxocarboxylic Acids as Versatile Synthons for the Preparation of Heterocycles","display_name":"4- and 5-Oxocarboxylic Acids as Versatile Synthons for the Preparation of Heterocycles","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W1982010446","doi":"https://doi.org/10.3987/rev-00-529","mag":"1982010446"},"language":"en","primary_location":{"id":"doi:10.3987/rev-00-529","doi":"https://doi.org/10.3987/rev-00-529","is_oa":false,"landing_page_url":"https://doi.org/10.3987/rev-00-529","pdf_url":null,"source":{"id":"https://openalex.org/S27298842","display_name":"Heterocycles","issn_l":"0385-5414","issn":["0385-5414","1881-0942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HETEROCYCLES","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108358331","display_name":"G\u00e9za St\u00e1jer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e9za St\u00e1jer","raw_affiliation_strings":["Szegedi Tudomanyegyetem"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Szegedi Tudomanyegyetem","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036088175","display_name":"Ferenc Csende","orcid":"https://orcid.org/0000-0001-5181-3958","observed_orcids":["https://orcid.org/0000-0001-5181-3958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferenc Csende","raw_affiliation_strings":["Taxus Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taxus Pharmaceuticals","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.557,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.57818537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"53","issue":"6","first_page":"1379","last_page":"1379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/synthons","display_name":"synthons","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hydrazones","display_name":"hydrazones","score":0.765999972820282},{"id":"https://openalex.org/keywords/phenylhydrazones","display_name":"phenylhydrazones","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hydroxylamine-derivatives","display_name":"hydroxylamine derivatives","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cyclocondensation","display_name":"cyclocondensation","score":0.796999990940094},{"id":"https://openalex.org/keywords/lactones","display_name":"lactones","score":0.7950000166893005},{"id":"https://openalex.org/keywords/lactams","display_name":"lactams","score":0.996999979019165},{"id":"https://openalex.org/keywords/thiophene-derivatives","display_name":"thiophene derivatives","score":0.8529999852180481},{"id":"https://openalex.org/keywords/indole-derivatives","display_name":"indole derivatives","score":0.5600000023841858},{"id":"https://openalex.org/keywords/carbazole","display_name":"carbazole","score":0.7139999866485596},{"id":"https://openalex.org/keywords/natural-product-synthesis","display_name":"natural product synthesis","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C40869318","wikidata":"https://www.wikidata.org/wiki/Q899050","display_name":"Synthon","level":2,"score":0.9812232255935669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9546241760253906},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.537659227848053},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.41452616453170776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3987/rev-00-529","doi":"https://doi.org/10.3987/rev-00-529","is_oa":false,"landing_page_url":"https://doi.org/10.3987/rev-00-529","pdf_url":null,"source":{"id":"https://openalex.org/S27298842","display_name":"Heterocycles","issn_l":"0385-5414","issn":["0385-5414","1881-0942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HETEROCYCLES","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1545599709","https://openalex.org/W1882439985","https://openalex.org/W1964238150","https://openalex.org/W1966226993","https://openalex.org/W1966902146","https://openalex.org/W1968674035","https://openalex.org/W1971139043","https://openalex.org/W1976163367","https://openalex.org/W1982652080","https://openalex.org/W1986282602","https://openalex.org/W1991772404","https://openalex.org/W1992548820","https://openalex.org/W1995131499","https://openalex.org/W2000291317","https://openalex.org/W2000597086","https://openalex.org/W2000722285","https://openalex.org/W2003029211","https://openalex.org/W2003031567","https://openalex.org/W2004330033","https://openalex.org/W2004710645","https://openalex.org/W2006568227","https://openalex.org/W2010995473","https://openalex.org/W2013022115","https://openalex.org/W2016660719","https://openalex.org/W2022698860","https://openalex.org/W2026057491","https://openalex.org/W2029017989","https://openalex.org/W2029834681","https://openalex.org/W2034424248","https://openalex.org/W2037792043","https://openalex.org/W2039137191","https://openalex.org/W2040801619","https://openalex.org/W2042911349","https://openalex.org/W2043321441","https://openalex.org/W2054060323","https://openalex.org/W2056799377","https://openalex.org/W2060728625","https://openalex.org/W2060923548","https://openalex.org/W2068096920","https://openalex.org/W2068253001","https://openalex.org/W2068937663","https://openalex.org/W2068962790","https://openalex.org/W2072353357","https://openalex.org/W2072709341","https://openalex.org/W2073024338","https://openalex.org/W2073791831","https://openalex.org/W2080500471","https://openalex.org/W2080676771","https://openalex.org/W2080950177","https://openalex.org/W2081117439","https://openalex.org/W2086562023","https://openalex.org/W2087069700","https://openalex.org/W2088562198","https://openalex.org/W2112295781","https://openalex.org/W2115787212","https://openalex.org/W2121237898","https://openalex.org/W2155668227","https://openalex.org/W2163056784","https://openalex.org/W2291107078","https://openalex.org/W2316783576","https://openalex.org/W2317950810","https://openalex.org/W2328372924","https://openalex.org/W2331462513","https://openalex.org/W2333146471","https://openalex.org/W2345809693","https://openalex.org/W2401788803","https://openalex.org/W2417990211","https://openalex.org/W2503464137","https://openalex.org/W2912901110","https://openalex.org/W2949224979","https://openalex.org/W2949360530","https://openalex.org/W2949868390","https://openalex.org/W2949877700","https://openalex.org/W2950460622","https://openalex.org/W2951067535","https://openalex.org/W2951519359","https://openalex.org/W2952134152","https://openalex.org/W2952262404","https://openalex.org/W2952476518","https://openalex.org/W2952748104","https://openalex.org/W2953133198","https://openalex.org/W2953310527","https://openalex.org/W3006735941","https://openalex.org/W4235883172","https://openalex.org/W4238849610","https://openalex.org/W4247195848","https://openalex.org/W4248263256","https://openalex.org/W4249287320","https://openalex.org/W4253880610"],"related_works":["https://openalex.org/W2952470296","https://openalex.org/W2088432538","https://openalex.org/W7217637336","https://openalex.org/W2033245108","https://openalex.org/W2951389661","https://openalex.org/W2073082120","https://openalex.org/W4416371401","https://openalex.org/W2004986050","https://openalex.org/W1975102753","https://openalex.org/W2949432558"],"abstract_inverted_index":{"Conversions":[0],"of":[1,8,23,49,58,96,170],"4-and":[2],"5-oxocarboxylic":[3],"acids":[4],"for":[5],"the":[6,14,20,92,104,188],"preparation":[7],"heterocycles":[9],"are":[10],"discussed.The":[11],"review":[12],"illustrates":[13],"importance":[15],"and":[16,18],"variability":[17],"presents":[19],"synthetic":[21],"applicability":[22],"these":[24],"versatile":[25],"synthons.CONTENTS":[26],"1.":[27],"Introduction":[28],"2.":[29],"Reactions":[30,34],"with":[31,35,39,101],"hydrazines":[32],"3.":[33],"hydroxylamine":[36],"4.":[37],"Cyclocondensations":[38],"bifunctional":[40],"amino":[41],"derivatives":[42,55],"5.":[43],"Cyclizations":[44],"to":[45,53,175],"lactones":[46],"6.":[47],"Formation":[48],"lactams":[50],"7.":[51],"Conversion":[52],"thiophene":[54],"8.":[56],"Syntheses":[57],"natural":[59],"products.Other":[60],"ring":[61],"systems":[62],"RCOCl":[63],"AlCl":[64],"3":[65],"NH":[66,68,78],"2":[67,69,113,148,150,153,196],"O":[70,71,74,76,77,80,84,85,151,161],"COOH":[72,159,162],"R":[73,81,110,112,129,185],"10":[75],"N":[79,156],"11":[82],"H":[83,118,126,134,141,149,152],"COO":[86],"9":[87],"Scheme":[88,166],"4In":[89],"aqueous":[90],"solution,":[91],"sulfuric":[93],"acid-catalysed":[94],"reaction":[95],"3-methyl-4-oxopentanoic":[97],"acid":[98],"(":[99,197],"12)":[100],"phenylhydrazine":[102],"gives":[103],"indole":[105,181],"derivative":[106],"(13).":[107],"60(Scheme":[108],"5)":[109],"1":[111],"yield":[114,130],"(%)":[115,131],"ref.":[116],"3-pyridil":[117],"57":[119],"49":[120],"Ph":[121,122],"43":[123],"46":[124],"2-thienyl":[125],"40":[127],"48":[128],"ref.C":[132],"6":[133,140],"4":[135,142,155],"Me-4":[136],"89":[137],"58":[138],"C":[139],"Cl-4":[143],"85":[144],"59":[145],"+":[146],"NHNH":[147],"SO":[154],"Me":[157,158,163,164],"13":[160],"12":[165],"5":[167],"The":[168],"phenylhydrazones":[169],"14":[171],"have":[172],"been":[173],"cyclized":[174],"fused":[176],"tetracyclic":[177],"compounds":[178],"containing":[179],"an":[180],"moiety":[182],"(15).":[183],"61When":[184],"=":[186,195],"COOEt,":[187],"carbazole":[189],"(16)":[190],"was":[191],"formed.(Scheme":[192],"6)":[193],"n":[194,199],")":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}