{"id":"https://openalex.org/W1982005407","doi":"https://doi.org/10.1021/bi00682a037","title":"Conformation of glucagon. Predictions and consequences","display_name":"Conformation of glucagon. Predictions and consequences","publication_year":1975,"publication_date":"1975-06-01","ids":{"openalex":"https://openalex.org/W1982005407","doi":"https://doi.org/10.1021/bi00682a037","mag":"1982005407","pmid":"https://pubmed.ncbi.nlm.nih.gov/1138871"},"language":"en","primary_location":{"id":"doi:10.1021/bi00682a037","doi":"https://doi.org/10.1021/bi00682a037","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00682a037","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063767875","display_name":"Peter Y. Chou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Y. Chou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087526768","display_name":"Gerald D. Fasman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald D. Fasman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.3958,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.88300988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"11","first_page":"2536","last_page":"2541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":1.0},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-secondary-structure-prediction","display_name":"secondary structure prediction","score":0.902999997138977},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.8019999861717224},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.9679999947547913},{"id":"https://openalex.org/keywords/beta-turn","display_name":"beta-turn","score":0.75},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.8399999737739563},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.5},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6510000228881836},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.9288007020950317},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6634739637374878},{"id":"https://openalex.org/C159547669","wikidata":"https://www.wikidata.org/wiki/Q283449","display_name":"Beta sheet","level":3,"score":0.651643693447113},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.5627315640449524},{"id":"https://openalex.org/C184538305","wikidata":"https://www.wikidata.org/wiki/Q283399","display_name":"Alpha helix","level":3,"score":0.5089261531829834},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.47341567277908325},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4725113809108734},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.46027040481567383},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.46023109555244446},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4286544919013977},{"id":"https://openalex.org/C34349673","wikidata":"https://www.wikidata.org/wiki/Q899124","display_name":"Random coil","level":3,"score":0.4108430743217468},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27620619535446167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22478801012039185},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11330699920654297},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00682a037","doi":"https://doi.org/10.1021/bi00682a037","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00682a037","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:1138871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1138871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003305588","https://openalex.org/W2078206727","https://openalex.org/W2093791427","https://openalex.org/W1594927168","https://openalex.org/W2143950631","https://openalex.org/W2126695916","https://openalex.org/W49520081","https://openalex.org/W2086070857","https://openalex.org/W1985800329","https://openalex.org/W3005174091"],"abstract_inverted_index":{"It":[0],"is":[1,8,218],"proposed":[2,240],"that":[3,180,258],"glucagon,":[4,144],"a":[5,17,102,186],"polypeptide":[6],"hormone,":[7],"delicately":[9],"balanced":[10],"between":[11],"two":[12],"major":[13],"conformational":[14,34,56,89,303],"states.":[15],"Utilizing":[16],"new":[18],"predictive":[19,280],"model":[20],"[Chou,":[21],"P.Y.,":[22],"and":[23,43,134,162,183,201,212,265],"Fasman,":[24],"G.D.":[25],"(1974),":[26],"Biochemistry":[27],"13,":[28],"222]":[29],"which":[30,66,241],"considers":[31],"all":[32],"the":[33,46,119,129,138,176,244,278,283,290,301,307],"states":[35,90],"in":[36,128,143,173,208,230,270,277,294],"proteins":[37],"(helix,":[38],"beta":[39,44,141,152,166,193,225,245],"sheet,":[40],"random":[41],"coil,":[42],"turns),":[45],"secondary":[47],"structural":[48],"regions":[49],"of":[50,58,73,84,124,132,140,148,247,252,272,286,292],"glucagon":[51,59,133,181,203,231,248,259,293],"are":[52,91,165,195,239],"computed":[53],"herein.":[54],"The":[55,126,255],"sensitivity":[57],"may":[60,204],"be":[61,268,298],"due":[62],"to":[63,261],"residues":[64,99,106,160,163,198,228],"19-27":[65,107],"have":[67,185],"both":[68,158],"alpha-helical":[69,110],"potential":[70,81],"(mean":[71,82],"value":[72,83],"Palpha":[74],"=":[75,86],"1.19)":[76],"as":[77,79,275],"well":[78,117],"beta-sheet":[80,103,188,273],"Pbeta":[85],"1.25).":[87],"Two":[88],"predicted":[92,96,155,196],"for":[93],"glucagon.":[94,125],"In":[95,154],"form":[97,101,108,156,262],"(a),":[98],"5-10":[100,161],"region":[104,111],"while":[105],"an":[109,221],"(31%":[112],"alpha,":[113,170],"21%":[114],"beta)":[115,172],"agreeing":[116],"with":[118,175,210,249],"circular":[120],"dichroism":[121],"(CD)":[122],"spectra":[123,131],"similarity":[127],"CD":[130],"insulin":[135,149],"further":[136],"suggests":[137],"presence":[139],"structure":[142,207],"since":[145],"X-ray":[146],"analysis":[147],"showed":[150],"24%":[151],"sheet.":[153],"(b),":[157],"regions,":[159],"19-27,":[164],"sheets":[167,168,246],"(0%":[169],"52%":[171],"agreement":[174,209],"infrared":[177],"spectral":[178],"evidence":[179],"gels":[182],"fibrils":[184],"predominant":[187],"conformation.":[189],"Since":[190],"three":[191],"reverse":[192],"turns":[194],"at":[197,227],"2-5,":[199],"10-13,":[200],"15-18,":[202],"possess":[205],"tertiary":[206],"viscosity":[211],"tritium-hydrogen":[213],"exchange":[214],"experiments.":[215],"A":[216],"proposal":[217],"offered":[219],"concerning":[220,289],"induced":[222],"alpha":[223],"yields":[224],"transition":[226,304],"22-27":[229],"during":[232],"receptor":[233],"site":[234],"binding.":[235],"Amino":[236],"acid":[237],"substitutions":[238],"should":[242],"disrupt":[243],"concomitant":[250],"loss":[251],"biological":[253],"activity.":[254],"experimental":[256],"findings":[257],"aggregates":[260],"dimers,":[263],"trimers,":[264],"hexamers":[266],"can":[267,297],"explained":[269],"terms":[271],"interactions":[274],"outlined":[276],"present":[279],"model.":[281],"Thus":[282],"conflicting":[284],"conclusions":[285],"previous":[287],"workers,":[288],"conformation":[291],"different":[295],"environments,":[296],"rationalized":[299],"by":[300],"suggested":[302],"occurring":[305],"within":[306],"molecule.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}