{"id":"https://openalex.org/W1982004248","doi":"https://doi.org/10.1179/joc.2002.14.4.361","title":"Diffusion of Isepamicin into Cancellous and Cortical Bone Tissue","display_name":"Diffusion of Isepamicin into Cancellous and Cortical Bone Tissue","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1982004248","doi":"https://doi.org/10.1179/joc.2002.14.4.361","mag":"1982004248","pmid":"https://pubmed.ncbi.nlm.nih.gov/12420853"},"language":"en","primary_location":{"id":"doi:10.1179/joc.2002.14.4.361","doi":"https://doi.org/10.1179/joc.2002.14.4.361","is_oa":false,"landing_page_url":"https://doi.org/10.1179/joc.2002.14.4.361","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001923755","display_name":"Emmanuel Boselli","orcid":"https://orcid.org/0000-0002-4949-3518","observed_orcids":["https://orcid.org/0000-0002-4949-3518"]},"institutions":[{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210163327","display_name":"H\u00f4tel-Dieu de Lyon","ror":"https://ror.org/04sx7v519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210163327"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Boselli","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, H\u0135tel-Dieu Hospital, Lyon, France. emmanuel.boselli@chu-lyon.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, H\u0135tel-Dieu Hospital, Lyon, France. emmanuel.boselli@chu-lyon.fr","institution_ids":["https://openalex.org/I4210100596","https://openalex.org/I4210163327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012034145","display_name":"Dominique Breilh","orcid":"https://orcid.org/0000-0002-3783-2797","observed_orcids":["https://orcid.org/0000-0002-3783-2797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Breilh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113848291","display_name":"Jean-Christophe Bel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.C. Bel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048844055","display_name":"Richard Debon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Debon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026504867","display_name":"Marie\u2010Claude Saux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.C. Saux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010065275","display_name":"DOMINIQUE CHASSARD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Chassard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014519093","display_name":"Bernard Allaouchiche","orcid":"https://orcid.org/0000-0003-0988-1716","observed_orcids":["https://orcid.org/0000-0003-0988-1716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Allaouchiche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1757,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.54505266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"4","first_page":"361","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.3515999913215637,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isepamicin","display_name":"isepamicin","score":1.0},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":1.0},{"id":"https://openalex.org/keywords/bone-and-joint-infections","display_name":"bone and joint infections","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":0.8949999809265137},{"id":"https://openalex.org/keywords/bone-removal","display_name":"bone removal","score":0.46399998664855957},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.6549999713897705},{"id":"https://openalex.org/keywords/mic90","display_name":"MIC90","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antibiotic-efficacy","display_name":"antibiotic efficacy","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.7160667777061462},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.6421947479248047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6343106031417847},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5460940599441528},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.5211479663848877},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5057971477508545},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4518435001373291},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.44329750537872314},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43201613426208496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3765208125114441},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.30061447620391846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29503530263900757},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14495736360549927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005839","descriptor_name":"Gentamicins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006615","descriptor_name":"Hip","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/joc.2002.14.4.361","doi":"https://doi.org/10.1179/joc.2002.14.4.361","is_oa":false,"landing_page_url":"https://doi.org/10.1179/joc.2002.14.4.361","pdf_url":null,"source":{"id":"https://openalex.org/S127202688","display_name":"Journal of Chemotherapy","issn_l":"1120-009X","issn":["1120-009X","1973-9478"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chemotherapy","raw_type":"journal-article"},{"id":"pmid:12420853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12420853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chemotherapy (Florence, Italy)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2048731896","https://openalex.org/W2081159764","https://openalex.org/W2081925252","https://openalex.org/W2092705980","https://openalex.org/W2106577380","https://openalex.org/W2113092757","https://openalex.org/W2154415535","https://openalex.org/W2434504360"],"related_works":["https://openalex.org/W2150147711","https://openalex.org/W2326146511","https://openalex.org/W2122504614","https://openalex.org/W2318920403","https://openalex.org/W2110988887","https://openalex.org/W2464092086","https://openalex.org/W2154415535","https://openalex.org/W2381350897","https://openalex.org/W2035298668","https://openalex.org/W2886577368"],"abstract_inverted_index":{"The":[0,136,155,179,208],"degree":[1],"of":[2,4,35,40,56,68,91,142,147,184,229,231,234,236],"penetration":[3,34],"an":[5,12],"antibiotic":[6],"into":[7],"the":[8,26,31,44,53,145,221,227,237],"infection":[9],"site":[10],"is":[11],"important":[13],"factor":[14],"in":[15,20,58,166,175,187,211,242],"its":[16],"therapeutic":[17],"efficacy,":[18],"particularly":[19],"bone":[21,32,59,95,148,168,177,188,198,206,216,243],"and":[22,43,74,94,105,117,170,189,200,214],"joint":[23],"infections.":[24,60,244],"In":[25,61],"present":[27],"study,":[28,66],"we":[29],"examined":[30],"tissue":[33,96,169,199,217],"isepamicin":[36,57,143,159,185],"at":[37,144],"a":[38,85,100,108],"dose":[39,90],"15":[41,88],"mg/Kg,":[42],"results":[45],"were":[46,78,98,134,161,192,218],"correlated":[47],"to":[48,51,225],"microbiologic":[49],"data":[50],"estimate":[52],"clinical":[54],"efficacy":[55],"this":[62],"open-label,":[63],"single-arm,":[64],"noncomparative":[65],"subjects":[67],"similar":[69],"age,":[70,121],"body":[71,125],"weight,":[72,126],"height":[73],"creatinine":[75,130],"clearance":[76],"who":[77],"undergoing":[79],"elective":[80],"total":[81],"hip":[82],"replacement":[83],"received":[84],"single,":[86],"parenteral":[87],"mg/Kg":[89],"isepamicin.":[92],"Plasma":[93],"samples":[97],"collected":[99],"mean":[101,120,124,129,137,156,180],"1.3":[102],"hours":[103],"later":[104],"analyzed":[106],"by":[107],"high-pressure":[109],"liquid":[110],"chromatography":[111],"method.":[112],"Twelve":[113],"patients":[114],"(3":[115],"men":[116],"9":[118],"women;":[119],"73.5":[122],"years;":[123],"53.5":[127],"Kg,":[128],"clearance,":[131],"58.5":[132],"mL/min)":[133],"enrolled.":[135],"+/-":[138,152,157,163,172,181,194,202],"SD":[139,158,182],"plasma":[140,190],"concentration":[141,186],"time":[146],"removal":[149],"was":[150],"43.0":[151],"10.4":[153],"microg/mL.":[154],"concentrations":[160,209,223],"11.6":[162],"7.1":[164],"microg/mL":[165,174],"cancellous":[167,197,213],"12.0":[171],"7.3":[173],"cortical":[176,205,215],"tissue.":[178,207],"ratios":[183],"(bone/plasma)":[191],"0.28":[193],"0.14":[195],"for":[196,204],"0.31":[201],"0.20":[203],"achieved":[210],"both":[212],"greater":[219],"than":[220],"minimum":[222],"required":[224],"inhibit":[226],"growth":[228],"90%":[230],"strains":[232],"(MIC90)":[233],"most":[235],"susceptible":[238],"pathogens":[239],"commonly":[240],"involved":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}