{"id":"https://openalex.org/W1981969443","doi":"https://doi.org/10.1038/ncb1848","title":"Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase","display_name":"Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase","publication_year":2009,"publication_date":"2009-03-15","ids":{"openalex":"https://openalex.org/W1981969443","doi":"https://doi.org/10.1038/ncb1848","mag":"1981969443","pmid":"https://pubmed.ncbi.nlm.nih.gov/19287380","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2754075"},"language":"en","primary_location":{"id":"doi:10.1038/ncb1848","doi":"https://doi.org/10.1038/ncb1848","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb1848","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2754075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049653548","display_name":"Subbareddy Maddika","orcid":"https://orcid.org/0000-0002-5880-391X","observed_orcids":["https://orcid.org/0000-0002-5880-391X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subbareddy Maddika","raw_affiliation_strings":["Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, 06520, Connecticut, USA","Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, 06520, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale University School of Medicine, PO Box 208040, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100365539"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.1069,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.96900238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"11","issue":"4","first_page":"409","last_page":"419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dyrk2","display_name":"DYRK2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/edd","display_name":"EdD","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ddb1","display_name":"DDB1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vprbp","display_name":"VprBP","score":0.996999979019165},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.9000957608222961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7167778611183167},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6823738813400269},{"id":"https://openalex.org/C140248907","wikidata":"https://www.wikidata.org/wiki/Q17913449","display_name":"DDB1","level":5,"score":0.6386098861694336},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.6343258619308472},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5764602422714233},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.5305025577545166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5163049101829529},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42855334281921387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37351828813552856},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33159497380256653},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04710295796394348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074201","descriptor_name":"Katanin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097603","descriptor_name":"Dyrk Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/ncb1848","doi":"https://doi.org/10.1038/ncb1848","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ncb1848","pdf_url":null,"source":{"id":"https://openalex.org/S151741590","display_name":"Nature Cell Biology","issn_l":"1465-7392","issn":["1465-7392","1476-4679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cell Biology","raw_type":"journal-article"},{"id":"pmid:19287380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19287380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2754075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2754075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2754075","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2754075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7801941453","display_name":"Study the Role of Chfr in Tumorigenesis","funder_award_id":"R01CA113381","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000912503","display_name":"Mayo Clinic Breast Cancer SPORE","funder_award_id":"P50CA116201","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1608064898","https://openalex.org/W1831651395","https://openalex.org/W1970320023","https://openalex.org/W1972378799","https://openalex.org/W1982341119","https://openalex.org/W1982855701","https://openalex.org/W1985585046","https://openalex.org/W1997257842","https://openalex.org/W2008561915","https://openalex.org/W2013625182","https://openalex.org/W2028904305","https://openalex.org/W2030205108","https://openalex.org/W2032735361","https://openalex.org/W2044046427","https://openalex.org/W2046049180","https://openalex.org/W2067518266","https://openalex.org/W2068784898","https://openalex.org/W2069489971","https://openalex.org/W2074079209","https://openalex.org/W2074398665","https://openalex.org/W2077229666","https://openalex.org/W2079491737","https://openalex.org/W2079867322","https://openalex.org/W2082557543","https://openalex.org/W2101026479","https://openalex.org/W2109458412","https://openalex.org/W2129473323","https://openalex.org/W2134703818","https://openalex.org/W2135220248","https://openalex.org/W2142634040","https://openalex.org/W2157982286","https://openalex.org/W2166109261","https://openalex.org/W4299809598"],"related_works":["https://openalex.org/W7100818826","https://openalex.org/W3167821821","https://openalex.org/W2002129054","https://openalex.org/W4220997051","https://openalex.org/W7098329057","https://openalex.org/W7065043332","https://openalex.org/W2008766026","https://openalex.org/W1549375498","https://openalex.org/W1985476964","https://openalex.org/W2743207357"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}