{"id":"https://openalex.org/W1981968485","doi":"https://doi.org/10.1016/j.urolonc.2014.12.004","title":"A window into new drug development for urologic oncology. Part I: How bench-to-bedside research can result in approval","display_name":"A window into new drug development for urologic oncology. Part I: How bench-to-bedside research can result in approval","publication_year":2015,"publication_date":"2015-01-22","ids":{"openalex":"https://openalex.org/W1981968485","doi":"https://doi.org/10.1016/j.urolonc.2014.12.004","mag":"1981968485","pmid":"https://pubmed.ncbi.nlm.nih.gov/25620153"},"language":"en","primary_location":{"id":"doi:10.1016/j.urolonc.2014.12.004","doi":"https://doi.org/10.1016/j.urolonc.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.urolonc.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S4802544","display_name":"Urologic Oncology Seminars and Original Investigations","issn_l":"1078-1439","issn":["1078-1439","1873-2496"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologic Oncology: Seminars and Original Investigations","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109651628","display_name":"Gabriel P. Haas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]},{"id":"https://openalex.org/I4210165171","display_name":"Astellas Pharma (United States)","ror":"https://ror.org/05pw69n24","country_code":"US","type":"company","lineage":["https://openalex.org/I142395110","https://openalex.org/I4210165171"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriel P. Haas","raw_affiliation_strings":["Astellas Global Medical Affairs, Northbrook, IL; Department of Urology, Loyola University School of Medicine, Maywood, IL. Electronic address: gabriel.haas@astellas.com","Astellas Global Medical Affairs, Northbrook, IL","Department of Urology, Loyola University School of Medicine, Maywood, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Global Medical Affairs, Northbrook, IL; Department of Urology, Loyola University School of Medicine, Maywood, IL. Electronic address: gabriel.haas@astellas.com","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Astellas Global Medical Affairs, Northbrook, IL","institution_ids":["https://openalex.org/I4210165171"]},{"raw_affiliation_string":"Department of Urology, Loyola University School of Medicine, Maywood, IL","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072850546","display_name":"Howard I. Scher","orcid":"https://orcid.org/0000-0002-6791-9324","observed_orcids":["https://orcid.org/0000-0002-6791-9324"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard I. Scher","raw_affiliation_strings":["Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY","Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY","Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5109651628"],"corresponding_institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390","https://openalex.org/I4210165171"],"apc_list":{"value":3440,"currency":"USD","value_usd":3440},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"3","first_page":"115","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.7760000228881836},{"id":"https://openalex.org/keywords/urological-oncology","display_name":"urologic oncology","score":0.9589999914169312},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.8130000233650208},{"id":"https://openalex.org/keywords/drug-approval","display_name":"drug approval","score":0.921999990940094},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.7605712413787842},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6192284822463989},{"id":"https://openalex.org/C2778751112","wikidata":"https://www.wikidata.org/wiki/Q835016","display_name":"Window (computing)","level":2,"score":0.5474553108215332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5229083895683289},{"id":"https://openalex.org/C2778363899","wikidata":"https://www.wikidata.org/wiki/Q23900955","display_name":"Window of opportunity","level":2,"score":0.471251517534256},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.4502323865890503},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37878870964050293},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.34348538517951965},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24396684765815735},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19172093272209167},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.10066300630569458},{"id":"https://openalex.org/C79403827","wikidata":"https://www.wikidata.org/wiki/Q3988","display_name":"Real-time computing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014571","descriptor_name":"Urologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014572","descriptor_name":"Urology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.urolonc.2014.12.004","doi":"https://doi.org/10.1016/j.urolonc.2014.12.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.urolonc.2014.12.004","pdf_url":null,"source":{"id":"https://openalex.org/S4802544","display_name":"Urologic Oncology Seminars and Original Investigations","issn_l":"1078-1439","issn":["1078-1439","1873-2496"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologic Oncology: Seminars and Original Investigations","raw_type":"journal-article"},{"id":"pmid:25620153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25620153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologic oncology","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2218192675","https://openalex.org/W4402438841","https://openalex.org/W2076246701","https://openalex.org/W1983746507","https://openalex.org/W2120690985","https://openalex.org/W4246070470","https://openalex.org/W4405952385","https://openalex.org/W7127112914","https://openalex.org/W622966401","https://openalex.org/W1984025658"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}