{"id":"https://openalex.org/W1981968355","doi":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","title":"Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19","display_name":"Genetic stability (in vivo) of the attenuated oral rabies virus vaccine SAD B19","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1981968355","doi":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","mag":"1981968355","pmid":"https://pubmed.ncbi.nlm.nih.gov/19161553"},"language":"en","primary_location":{"id":"doi:10.1111/j.1348-0421.2008.00085.x","doi":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","pdf_url":null,"source":{"id":"https://openalex.org/S149171590","display_name":"Microbiology and Immunology","issn_l":"0385-5600","issn":["0385-5600","1348-0421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061513843","display_name":"Aline Beckert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Aline Beckert","raw_affiliation_strings":["Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen, Germany","Institute of Epidemiology, Friedrich\u2010Loeffler\u2010Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen, Germany","institution_ids":["https://openalex.org/I1310048521"]},{"raw_affiliation_string":"Institute of Epidemiology, Friedrich\u2010Loeffler\u2010Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027236278","display_name":"Lutz Geue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz Geue","raw_affiliation_strings":["Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065219839","display_name":"Ad C. Vos","orcid":"https://orcid.org/0000-0002-9662-3127","observed_orcids":["https://orcid.org/0000-0002-9662-3127"]},"institutions":[{"id":"https://openalex.org/I4210131983","display_name":"IDT Biologika (Germany)","ror":"https://ror.org/03pmvdv44","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210131983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ad Vos","raw_affiliation_strings":["IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany","institution_ids":["https://openalex.org/I4210131983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109140621","display_name":"Andreas Neubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131983","display_name":"IDT Biologika (Germany)","ror":"https://ror.org/03pmvdv44","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210131983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Neubert","raw_affiliation_strings":["IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany","institution_ids":["https://openalex.org/I4210131983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026559156","display_name":"Conrad M. Freuling","orcid":"https://orcid.org/0000-0002-1076-398X","observed_orcids":["https://orcid.org/0000-0002-1076-398X"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Conrad Freuling","raw_affiliation_strings":["Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen","institution_ids":["https://openalex.org/I1310048521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015038856","display_name":"Thomas M\u00fcller","orcid":"https://orcid.org/0000-0002-0959-3653","observed_orcids":["https://orcid.org/0000-0002-0959-3653"]},"institutions":[{"id":"https://openalex.org/I1310048521","display_name":"Friedrich-Loeffler-Institut","ror":"https://ror.org/025fw7a54","country_code":"DE","type":"government","lineage":["https://openalex.org/I1310048521","https://openalex.org/I2801963157"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas M\u00fcller","raw_affiliation_strings":["Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Epidemiology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Seestrasse 55, 16868 Wusterhausen","institution_ids":["https://openalex.org/I1310048521"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015038856"],"corresponding_institution_ids":["https://openalex.org/I1310048521"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":null,"fwci":0.4529,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.59819073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"53","issue":"1","first_page":"16","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11780","display_name":"Rabies epidemiology and control","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11780","display_name":"Rabies epidemiology and control","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-stability","display_name":"genetic stability","score":0.9509999752044678},{"id":"https://openalex.org/keywords/in-vivo-passage","display_name":"in vivo passage","score":0.47099998593330383},{"id":"https://openalex.org/keywords/viral-reversion","display_name":"viral reversion","score":0.5920000076293945},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.7739999890327454},{"id":"https://openalex.org/keywords/foxes","display_name":"foxes","score":0.5839999914169312},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.8659999966621399},{"id":"https://openalex.org/keywords/serial-passage","display_name":"serial passage","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7921282052993774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7570026516914368},{"id":"https://openalex.org/C2776849203","wikidata":"https://www.wikidata.org/wiki/Q39222","display_name":"Rabies","level":2,"score":0.7029972076416016},{"id":"https://openalex.org/C2777961786","wikidata":"https://www.wikidata.org/wiki/Q698976","display_name":"Rabies virus","level":3,"score":0.6287620663642883},{"id":"https://openalex.org/C2780674857","wikidata":"https://www.wikidata.org/wiki/Q4007169","display_name":"Rabies vaccine","level":4,"score":0.5474305152893066},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5463767647743225},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.5036916136741638},{"id":"https://openalex.org/C109663412","wikidata":"https://www.wikidata.org/wiki/Q17052349","display_name":"Duck embryo vaccine","level":4,"score":0.4956139326095581},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.48340144753456116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13326230645179749},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.09666728973388672},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.048456549644470215}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005589","descriptor_name":"Foxes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011818","descriptor_name":"Rabies","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011819","descriptor_name":"Rabies Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011819","descriptor_name":"Rabies Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011820","descriptor_name":"Rabies virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011820","descriptor_name":"Rabies virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D012692","descriptor_name":"Serial Passage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1348-0421.2008.00085.x","doi":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1348-0421.2008.00085.x","pdf_url":null,"source":{"id":"https://openalex.org/S149171590","display_name":"Microbiology and Immunology","issn_l":"0385-5600","issn":["0385-5600","1348-0421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and Immunology","raw_type":"journal-article"},{"id":"pmid:19161553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19161553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology and immunology","raw_type":"Journal Article"},{"id":"pmh:oai:www.openagrar.de:fimport_mods_00000583","doi":null,"is_oa":false,"landing_page_url":"https://www.openagrar.de/receive/fimport_mods_00000583","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W96204766","https://openalex.org/W164880456","https://openalex.org/W1969027168","https://openalex.org/W1971000236","https://openalex.org/W1974216547","https://openalex.org/W1986762728","https://openalex.org/W1988024383","https://openalex.org/W1992425774","https://openalex.org/W2009031675","https://openalex.org/W2014461116","https://openalex.org/W2019612933","https://openalex.org/W2030244147","https://openalex.org/W2038906557","https://openalex.org/W2043170430","https://openalex.org/W2047618157","https://openalex.org/W2055320689","https://openalex.org/W2058824168","https://openalex.org/W2059419113","https://openalex.org/W2063478723","https://openalex.org/W2063489530","https://openalex.org/W2074365113","https://openalex.org/W2091684675","https://openalex.org/W2096365655","https://openalex.org/W2112040018","https://openalex.org/W2116294556","https://openalex.org/W2120253101","https://openalex.org/W2122953106","https://openalex.org/W2126051114","https://openalex.org/W2150532007"],"related_works":["https://openalex.org/W2150532007","https://openalex.org/W4298002491","https://openalex.org/W1982387938","https://openalex.org/W2058651395","https://openalex.org/W2436128636","https://openalex.org/W2030244147","https://openalex.org/W2409047352","https://openalex.org/W2356523009","https://openalex.org/W1973196025","https://openalex.org/W2055320689"],"abstract_inverted_index":{"The":[0],"distribution":[1],"of":[2,20,32,36,68,102,115],"oral":[3,41],"rabies":[4,42],"vaccine":[5,43],"baits":[6],"containing":[7],"replication-competent":[8],"live":[9],"viruses":[10],"poses":[11],"certain":[12],"environmental":[13],"safety":[14],"risks;":[15],"among":[16],"others,":[17],"the":[18,29,33,37,65,97,116,124],"possibility":[19],"reversion":[21],"to":[22,139],"or":[23],"an":[24,108],"increase":[25],"in":[26,56,74,80,107],"virulence.":[27,141],"Hence,":[28],"genetic":[30],"stability":[31],"complete":[34],"genome":[35],"most":[38],"widely":[39],"used":[40],"virus,":[44],"SAD":[45,69],"B19,":[46],"was":[47,62,71,86,120,131,136],"examined":[48],"after":[49],"four":[50],"and":[51,58,99],"10":[52,77],"serial":[53],"i.c.":[54],"passages":[55,79,127],"foxes":[57],"mice,":[59],"respectively.":[60],"It":[61],"shown":[63,132],"that":[64,133],"consensus":[66],"strain":[67],"B19":[70],"extremely":[72],"stable":[73],"vivo.":[75],"After":[76],"consecutive":[78],"mice":[81],"not":[82,121,137],"a":[83],"single":[84,91],"mutation":[85,119,135],"observed.":[87],"In":[88],"foxes,":[89],"seven":[90],"nucleotide":[92],"exchanges":[93],"were":[94],"found":[95],"between":[96],"first":[98,125],"fourth":[100],"passage,":[101],"which":[103],"only":[104],"one":[105],"resulted":[106],"amino":[109],"acid":[110],"exchange":[111],"at":[112],"position":[113],"9240":[114],"L-gene.":[117],"This":[118],"observed":[122],"during":[123],"three":[126],"and,":[128],"furthermore,":[129],"it":[130],"this":[134],"linked":[138],"enhanced":[140]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
