{"id":"https://openalex.org/W1981968296","doi":"https://doi.org/10.3389/fgene.2014.00206","title":"Evolutionary analysis of the cystatin family in three Schistosoma species","display_name":"Evolutionary analysis of the cystatin family in three Schistosoma species","publication_year":2014,"publication_date":"2014-07-09","ids":{"openalex":"https://openalex.org/W1981968296","doi":"https://doi.org/10.3389/fgene.2014.00206","mag":"1981968296","pmid":"https://pubmed.ncbi.nlm.nih.gov/25071834","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4089355"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2014.00206","doi":"https://doi.org/10.3389/fgene.2014.00206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00206","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00206/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00206/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056954210","display_name":"Yesid Cuesta-Astroz","orcid":"https://orcid.org/0000-0002-4243-0645","observed_orcids":["https://orcid.org/0000-0002-4243-0645"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210103337","display_name":"Centro de Excel\u00eancia em Bioinform\u00e1tica","ror":"https://ror.org/01dyrk434","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210103337"]},{"id":"https://openalex.org/I4210151028","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126","country_code":"BR","type":"facility","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210127675","https://openalex.org/I4210151028","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yesid Cuesta-Astroz","raw_affiliation_strings":["Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais Belo Horizonte, Brazil","Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4210103337","https://openalex.org/I4210151028","https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112233694","display_name":"Larissa Scholte","orcid":"https://orcid.org/0000-0001-5671-9960","observed_orcids":["https://orcid.org/0000-0001-5671-9960"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]},{"id":"https://openalex.org/I4210103337","display_name":"Centro de Excel\u00eancia em Bioinform\u00e1tica","ror":"https://ror.org/01dyrk434","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210103337"]},{"id":"https://openalex.org/I4210151028","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126","country_code":"BR","type":"facility","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210127675","https://openalex.org/I4210151028","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Larissa L. S. Scholte","raw_affiliation_strings":["Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais Belo Horizonte, Brazil","Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422","https://openalex.org/I4210103337","https://openalex.org/I4210151028","https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026298246","display_name":"Fabiano Sviatopolk-Mirsky Pais","orcid":"https://orcid.org/0000-0001-5958-2867","observed_orcids":["https://orcid.org/0000-0001-5958-2867"]},"institutions":[{"id":"https://openalex.org/I4210103337","display_name":"Centro de Excel\u00eancia em Bioinform\u00e1tica","ror":"https://ror.org/01dyrk434","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210103337"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiano Sviatopolk-Mirsky Pais","raw_affiliation_strings":["Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Faculdade Inf\u00f3rium de Tecnologia Belo Horizonte, Brazil","Faculdade Inf\u00f3rium de Tecnologia, Belo Horizonte, Brazil","Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Faculdade Inf\u00f3rium de Tecnologia Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"Faculdade Inf\u00f3rium de Tecnologia, Belo Horizonte, Brazil","institution_ids":[]},{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048496084","display_name":"Guilherme Oliveira","orcid":"https://orcid.org/0000-0003-0054-3438","observed_orcids":["https://orcid.org/0000-0003-0054-3438"]},"institutions":[{"id":"https://openalex.org/I4210103337","display_name":"Centro de Excel\u00eancia em Bioinform\u00e1tica","ror":"https://ror.org/01dyrk434","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210103337"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Oliveira","raw_affiliation_strings":["Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054966384","display_name":"Laila Alves Nahum","orcid":"https://orcid.org/0000-0002-4060-1105","observed_orcids":["https://orcid.org/0000-0002-4060-1105"]},"institutions":[{"id":"https://openalex.org/I4210103337","display_name":"Centro de Excel\u00eancia em Bioinform\u00e1tica","ror":"https://ror.org/01dyrk434","country_code":"BR","type":"other","lineage":["https://openalex.org/I4210103337"]},{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Laila A. Nahum","raw_affiliation_strings":["Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Faculdade Inf\u00f3rium de Tecnologia Belo Horizonte, Brazil","Faculdade Inf\u00f3rium de Tecnologia, Belo Horizonte, Brazil","Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz) Belo Horizonte, Brazil ; Faculdade Inf\u00f3rium de Tecnologia Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"Faculdade Inf\u00f3rium de Tecnologia, Belo Horizonte, Brazil","institution_ids":[]},{"raw_affiliation_string":"Grupo de Gen\u00f4mica e Biologia Computacional, Centro de Excel\u00eancia em Bioinform\u00e1tica, Instituto Nacional de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais, Centro de Pesquisas Ren\u00e9 Rachou (CPqRR), Funda\u00e7\u00e3o Oswaldo Cruz (Fiocruz), Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054966384"],"corresponding_institution_ids":["https://openalex.org/I4210103337","https://openalex.org/I4405286130","https://openalex.org/I52325"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.464,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.76982477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":null,"first_page":"206","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10815","display_name":"Parasite Biology and Host Interactions","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma","display_name":"Schistosoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cysteine-protease-inhibitors","display_name":"cysteine protease inhibitors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/platyhelminthes","display_name":"Platyhelminthes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/protein-evolution","display_name":"protein evolution","score":0.578000009059906},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.746999979019165},{"id":"https://openalex.org/keywords/developmental-gene-expression","display_name":"developmental gene expression","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8355375528335571},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.7407386898994446},{"id":"https://openalex.org/C2778491710","wikidata":"https://www.wikidata.org/wiki/Q1457418","display_name":"Schistosoma","level":5,"score":0.710623025894165},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.6684538722038269},{"id":"https://openalex.org/C2780412452","wikidata":"https://www.wikidata.org/wiki/Q4505907","display_name":"Cystatin","level":4,"score":0.6355090141296387},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4660920202732086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4367254972457886},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.40443509817123413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3716135323047638},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.22424021363258362},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.19658464193344116},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.19199535250663757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06115955114364624},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.0},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3389/fgene.2014.00206","doi":"https://doi.org/10.3389/fgene.2014.00206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00206","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00206/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmid:25071834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25071834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4089355","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4089355/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/11205","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/11205","pdf_url":"https://arca.fiocruz.br/bitstreams/e42eb663-2eb6-4c89-bcf5-ba3eabc08884/download","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2311879","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2311879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:arca.fiocruz.br:icict/11205","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/11205","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:arca.fiocruz.br:icict/50605","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/50605","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:c534a86066534ea99206d1d7d5484533","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c534a86066534ea99206d1d7d5484533","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 5 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2014.00206","doi":"https://doi.org/10.3389/fgene.2014.00206","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2014.00206","pdf_url":"https://www.frontiersin.org/articles/10.3389/fgene.2014.00206/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1690248604","display_name":null,"funder_award_id":"573839/2008-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1906217239","display_name":null,"funder_award_id":"309312/2012\u20134","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1927022175","display_name":null,"funder_award_id":"573839/2008-5","funder_id":"https://openalex.org/F4320324025","funder_display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais"},{"id":"https://openalex.org/G3003150400","display_name":null,"funder_award_id":"309312/2012-4","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G3566165748","display_name":"IDENTIFICA\u00c7\u00c3O DE NOVOS ALVOS PARA O COMBATE A ESQUISTOSSOMOSE","funder_award_id":"PPM-00439-10","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G581965161","display_name":null,"funder_award_id":"2012-4","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7281000230","display_name":"Infectious Disease Genomics and Bioinformatics Training in Brazil","funder_award_id":"D43TW007012","funder_id":"https://openalex.org/F4320337356","funder_display_name":"Fogarty International Center"}],"funders":[{"id":"https://openalex.org/F4320310084","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"},{"id":"https://openalex.org/F4320324025","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","ror":"https://ror.org/05fbb1126"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981968296.pdf","grobid_xml":"https://content.openalex.org/works/W1981968296.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W46604872","https://openalex.org/W118013854","https://openalex.org/W1505828408","https://openalex.org/W1564276617","https://openalex.org/W1968387458","https://openalex.org/W1979831978","https://openalex.org/W1979880724","https://openalex.org/W1983426701","https://openalex.org/W1992534162","https://openalex.org/W2008001323","https://openalex.org/W2008720360","https://openalex.org/W2009393104","https://openalex.org/W2009681761","https://openalex.org/W2012500659","https://openalex.org/W2016714416","https://openalex.org/W2020043868","https://openalex.org/W2024072710","https://openalex.org/W2024297705","https://openalex.org/W2026007165","https://openalex.org/W2033130744","https://openalex.org/W2036295062","https://openalex.org/W2039328194","https://openalex.org/W2041905742","https://openalex.org/W2055949495","https://openalex.org/W2056990705","https://openalex.org/W2066835202","https://openalex.org/W2068691406","https://openalex.org/W2072490996","https://openalex.org/W2075550764","https://openalex.org/W2084877342","https://openalex.org/W2094169801","https://openalex.org/W2094201044","https://openalex.org/W2097912624","https://openalex.org/W2100305481","https://openalex.org/W2104973679","https://openalex.org/W2107506178","https://openalex.org/W2107618620","https://openalex.org/W2109160513","https://openalex.org/W2110947816","https://openalex.org/W2111211467","https://openalex.org/W2114068433","https://openalex.org/W2117131162","https://openalex.org/W2120772351","https://openalex.org/W2122518986","https://openalex.org/W2122863289","https://openalex.org/W2125111965","https://openalex.org/W2135449563","https://openalex.org/W2136550480","https://openalex.org/W2138122982","https://openalex.org/W2141469080","https://openalex.org/W2143399295","https://openalex.org/W2144654387","https://openalex.org/W2146058063","https://openalex.org/W2147202122","https://openalex.org/W2147526198","https://openalex.org/W2154744452","https://openalex.org/W2157772863","https://openalex.org/W2341820741","https://openalex.org/W2411195336","https://openalex.org/W2419449550","https://openalex.org/W2605068739","https://openalex.org/W4230386739","https://openalex.org/W4240376307","https://openalex.org/W4299662206"],"related_works":["https://openalex.org/W7095101922","https://openalex.org/W3127261562","https://openalex.org/W2084877342","https://openalex.org/W2060200634","https://openalex.org/W7095924803","https://openalex.org/W2008720360","https://openalex.org/W2147202122","https://openalex.org/W7162195127","https://openalex.org/W2158478277","https://openalex.org/W3043466479"],"abstract_inverted_index":{"The":[0,40,126],"cystatin":[1,15,46],"family":[2],"comprises":[3],"cysteine":[4],"protease":[5],"inhibitors":[6],"distributed":[7],"in":[8,35,48,67,94,121,131,203,218],"3":[9],"subfamilies":[10],"(I25A-C).":[11],"Family":[12],"members":[13,117],"lacking":[14],"activity":[16],"are":[17,144,176],"currently":[18],"unclassified.":[19],"Little":[20],"is":[21],"known":[22],"about":[23],"the":[24,36,49,61,68,153,195,219],"evolution":[25],"of":[26,52,70,201,211,221],"Schistosoma":[27,54,79,95,142,156,204],"cystatins,":[28],"their":[29,135,148],"physiological":[30],"roles,":[31],"and":[32,56,73,80,104,114,173,198,205,214],"expression":[33,86],"patterns":[34,87],"parasite":[37,212],"life":[38,185],"cycle.":[39],"present":[41],"study":[42,191],"aimed":[43],"to":[44,74],"identify":[45],"homologs":[47],"predicted":[50],"proteome":[51],"three":[53],"species":[55,123],"other":[57,162,206],"Platyhelminthes.":[58],"We":[59],"analyzed":[60],"amino":[62],"acid":[63],"sequence":[64],"diversity":[65],"focused":[66],"identification":[69,220],"protein":[71],"signatures":[72],"establish":[75],"evolutionary":[76],"relationships":[77],"among":[78],"experimentally":[81],"validated":[82],"human":[83,149],"cystatins.":[84],"Gene":[85],"were":[88,107,118],"obtained":[89],"from":[90,147,161],"different":[91,132],"developmental":[92],"stages":[93],"mansoni":[96],"using":[97],"microarray":[98],"data.":[99],"In":[100,188],"Schistosoma,":[101],"only":[102],"I25A":[103,172],"I25B":[105,154,174],"proteins":[106],"identified,":[108],"reflecting":[109,134],"little":[110],"functional":[111,199],"diversification.":[112],"I25C":[113],"unclassified":[115],"subfamily":[116],"not":[119],"identified":[120],"platyhelminth":[122,163],"here":[124],"analyzed.":[125],"resulting":[127],"phylogeny":[128],"placed":[129],"cystatins":[130,143,157,202],"clades,":[133],"molecular":[136],"diversity.":[137],"Our":[138],"findings":[139],"suggest":[140],"that":[141,171],"very":[145],"divergent":[146],"homologs,":[150],"especially":[151],"regarding":[152],"subfamily.":[155],"also":[158],"differ":[159],"significantly":[160],"homologs.":[164],"Finally,":[165],"transcriptome":[166],"data":[167],"publicly":[168],"available":[169],"indicated":[170],"genes":[175],"constitutively":[177],"expressed":[178],"thus":[179],"could":[180],"be":[181],"essential":[182],"for":[183],"schistosome":[184],"cycle":[186],"progression.":[187],"summary,":[189],"this":[190],"provides":[192],"insights":[193],"into":[194],"evolution,":[196],"classification,":[197],"diversification":[200],"Platyhelminthes,":[207],"improving":[208],"our":[209],"understanding":[210],"biology":[213],"opening":[215],"new":[216],"frontiers":[217],"novel":[222],"therapeutic":[223],"targets":[224],"against":[225],"helminthiases.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
