{"id":"https://openalex.org/W1981941925","doi":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","title":"Renal fibrosis in mice treated with human recombinant transforming growth factor-\u03b22","display_name":"Renal fibrosis in mice treated with human recombinant transforming growth factor-\u03b22","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1981941925","doi":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","mag":"1981941925","pmid":"https://pubmed.ncbi.nlm.nih.gov/11115070"},"language":"en","primary_location":{"id":"doi:10.1046/j.1523-1755.2000.00420.x","doi":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","pdf_url":"https://www.kidney-international.org/article/S0085-2538(15)47353-3/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.kidney-international.org/article/S0085-2538(15)47353-3/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111590529","display_name":"Steven R. Ledbetter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven Ledbetter","raw_affiliation_strings":["Genzyme Corporation, Framingham, Massachusetts 01701, USA. steve.ledbetter@genzyme.com","Genzyme Corporation Framingham, Massachusetts 01701 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, Massachusetts 01701, USA. steve.ledbetter@genzyme.com","institution_ids":[]},{"raw_affiliation_string":"Genzyme Corporation Framingham, Massachusetts 01701 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001253246","display_name":"Leslie S. Kurtzberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie Kurtzberg","raw_affiliation_strings":["Genzyme Corporation, Framingham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sineaid Doyle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sineaid Doyle","raw_affiliation_strings":["Genzyme Corporation, Framingham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, Massachusetts, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035952595","display_name":"Bruce M. Pratt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce M. Pratt","raw_affiliation_strings":["Genzyme Corporation, Framingham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genzyme Corporation, Framingham, Massachusetts, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111590529"],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.2939,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.77417549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"58","issue":"6","first_page":"2367","last_page":"2376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.23389999568462372,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta2","display_name":"transforming growth factor-beta2","score":0.9100000262260437},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8489999771118164},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/tissue-hypoxia","display_name":"tissue hypoxia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6347489356994629},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.631128191947937},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6232098340988159},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5985988974571228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5814653038978577},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.5588762760162354},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5367288589477539},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.4705412983894348},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.44901251792907715},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4323098361492157},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.43227308988571167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12073329091072083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1090344786643982},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011347","descriptor_name":"Procollagen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016319","descriptor_name":"Corrosion Casting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053781","descriptor_name":"Transforming Growth Factor beta2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1523-1755.2000.00420.x","doi":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","pdf_url":"https://www.kidney-international.org/article/S0085-2538(15)47353-3/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},{"id":"pmid:11115070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11115070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1523-1755.2000.00420.x","doi":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1523-1755.2000.00420.x","pdf_url":"https://www.kidney-international.org/article/S0085-2538(15)47353-3/pdf","source":{"id":"https://openalex.org/S97303050","display_name":"Kidney International","issn_l":"0085-2538","issn":["0085-2538","1523-1755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney International","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981941925.pdf","grobid_xml":"https://content.openalex.org/works/W1981941925.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W7538965","https://openalex.org/W55794321","https://openalex.org/W205136180","https://openalex.org/W1527844514","https://openalex.org/W1528159645","https://openalex.org/W1747761114","https://openalex.org/W1857295270","https://openalex.org/W1938683170","https://openalex.org/W1975128760","https://openalex.org/W1975988004","https://openalex.org/W1979494347","https://openalex.org/W1987277332","https://openalex.org/W1989222325","https://openalex.org/W1989670744","https://openalex.org/W2006687037","https://openalex.org/W2013409143","https://openalex.org/W2016972506","https://openalex.org/W2018058963","https://openalex.org/W2018355686","https://openalex.org/W2020225354","https://openalex.org/W2027693573","https://openalex.org/W2037753264","https://openalex.org/W2042159165","https://openalex.org/W2049634503","https://openalex.org/W2056338262","https://openalex.org/W2060663941","https://openalex.org/W2076709563","https://openalex.org/W2078287694","https://openalex.org/W2083549154","https://openalex.org/W2086771087","https://openalex.org/W2109054322","https://openalex.org/W2125229121","https://openalex.org/W2125985655","https://openalex.org/W2128520582","https://openalex.org/W2129122050","https://openalex.org/W2131405836","https://openalex.org/W2138443098","https://openalex.org/W2151243547","https://openalex.org/W2156108164","https://openalex.org/W2160557271","https://openalex.org/W2165885428","https://openalex.org/W2226160251","https://openalex.org/W2239574837","https://openalex.org/W2337780837","https://openalex.org/W2400182527","https://openalex.org/W2405144207","https://openalex.org/W2413048168","https://openalex.org/W2443575926","https://openalex.org/W4248739628","https://openalex.org/W4313342346","https://openalex.org/W6712769780"],"related_works":["https://openalex.org/W2109054322","https://openalex.org/W1993487971","https://openalex.org/W2128520582","https://openalex.org/W2365937626","https://openalex.org/W2143232800","https://openalex.org/W1965405222","https://openalex.org/W7538965","https://openalex.org/W2151601135","https://openalex.org/W2084005197","https://openalex.org/W2053882786"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
