{"id":"https://openalex.org/W1981908393","doi":"https://doi.org/10.1158/0008-5472.can-08-2796","title":"Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells","display_name":"Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells","publication_year":2009,"publication_date":"2009-07-21","ids":{"openalex":"https://openalex.org/W1981908393","doi":"https://doi.org/10.1158/0008-5472.can-08-2796","mag":"1981908393","pmid":"https://pubmed.ncbi.nlm.nih.gov/19622775"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-08-2796","doi":"https://doi.org/10.1158/0008-5472.can-08-2796","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-2796","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/15/6074/2866948/6074.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/69/15/6074/2866948/6074.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021884279","display_name":"Bruno Cadot","orcid":"https://orcid.org/0000-0002-1888-3898","observed_orcids":["https://orcid.org/0000-0002-1888-3898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Cadot","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060947301","display_name":"Mirko Brunetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mirko Brunetti","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084496226","display_name":"Sabina Coppari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabina Coppari","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053054157","display_name":"S. Fedeli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Fedeli","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066294430","display_name":"Emanuele de Rinaldis","orcid":"https://orcid.org/0000-0002-0221-1114","observed_orcids":["https://orcid.org/0000-0002-0221-1114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emanuele de Rinaldis","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045962","display_name":"Claudio Dello Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Dello Russo","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079603371","display_name":"Paola Gallinari","orcid":"https://orcid.org/0000-0002-0166-9422","observed_orcids":["https://orcid.org/0000-0002-0166-9422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Gallinari","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038017063","display_name":"Raffaele De Francesco","orcid":"https://orcid.org/0000-0001-8754-5123","observed_orcids":["https://orcid.org/0000-0001-8754-5123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaele De Francesco","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091404424","display_name":"Christian Steink\u00fchler","orcid":"https://orcid.org/0000-0001-8341-9699","observed_orcids":["https://orcid.org/0000-0001-8341-9699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Steinku\u0308hler","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028641408","display_name":"Gessica Filocamo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gessica Filocamo","raw_affiliation_strings":["Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, IRBM-Merck Research Laboratories, Rome, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.879,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.68349616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"15","first_page":"6074","last_page":"6082"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac4","display_name":"HDAC4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p53-loss","display_name":"p53 deficiency","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromosome-segregation-errors","display_name":"chromosome segregation errors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pp2a-b56","display_name":"PP2A-B56","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pp2a-regulatory-subunit","display_name":"PP2A regulatory subunit","score":0.8479999899864197},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C58793620","wikidata":"https://www.wikidata.org/wiki/Q21173206","display_name":"HDAC4","level":5,"score":0.7501187920570374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.702140212059021},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6208090782165527},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.557803213596344},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5144324898719788},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.45092955231666565},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4393322169780731},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.41577956080436707},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3742203712463379},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2781411409378052},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2647411525249481},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20265209674835205},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10870537161827087},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-08-2796","doi":"https://doi.org/10.1158/0008-5472.can-08-2796","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-2796","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/15/6074/2866948/6074.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:19622775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19622775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/634746","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/634746","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/a5f0f17a-ce73-44b8-9416-5fb0076c81d2","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/a5f0f17a-ce73-44b8-9416-5fb0076c81d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cadot, B, Brunetti, M, Coppari, S, Fedeli, S, de Rinaldis, E, Dello Russo, C, Gallinari, P, De Francesco, R, Steink\u00fchler, C & Filocamo, G 2009, 'Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells', Cancer Research, vol. 69, no. 15, pp. 6074-6082. https://doi.org/10.1158/0008-5472.CAN-08-2796","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-08-2796","doi":"https://doi.org/10.1158/0008-5472.can-08-2796","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-08-2796","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/69/15/6074/2866948/6074.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981908393.pdf","grobid_xml":"https://content.openalex.org/works/W1981908393.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W31822687","https://openalex.org/W1967153587","https://openalex.org/W1972316915","https://openalex.org/W1972338617","https://openalex.org/W1979377700","https://openalex.org/W2005471059","https://openalex.org/W2010699331","https://openalex.org/W2020912062","https://openalex.org/W2031954417","https://openalex.org/W2042779242","https://openalex.org/W2049961455","https://openalex.org/W2050454126","https://openalex.org/W2058176738","https://openalex.org/W2059948085","https://openalex.org/W2068039999","https://openalex.org/W2071393652","https://openalex.org/W2072306817","https://openalex.org/W2074687765","https://openalex.org/W2099803844","https://openalex.org/W2101911974","https://openalex.org/W2102884982","https://openalex.org/W2103708119","https://openalex.org/W2112238103","https://openalex.org/W2116685428","https://openalex.org/W2119816761","https://openalex.org/W2120627772","https://openalex.org/W2121296685","https://openalex.org/W2130282432","https://openalex.org/W2133446638","https://openalex.org/W2141320234","https://openalex.org/W2141882676","https://openalex.org/W2142460487","https://openalex.org/W2144654038","https://openalex.org/W2154572495","https://openalex.org/W2159483734","https://openalex.org/W2171591325","https://openalex.org/W4233036449","https://openalex.org/W4240237951","https://openalex.org/W4251934001"],"related_works":["https://openalex.org/W2027409908","https://openalex.org/W1990887816","https://openalex.org/W2155631307","https://openalex.org/W2160593549","https://openalex.org/W2081973434","https://openalex.org/W2364613779","https://openalex.org/W2095664280","https://openalex.org/W2151089955","https://openalex.org/W2991310313","https://openalex.org/W2080304713"],"abstract_inverted_index":{"We":[0,149,191],"investigated":[1],"the":[2,67,91,116,133,138,180,187,199],"role":[3,20],"of":[4,31,93,131,142,159,166,189,203],"histone":[5],"deacetylase":[6],"4":[7],"(HDAC4)":[8],"using":[9],"RNA":[10],"interference":[11,197],"(RNAi)":[12],"and":[13,27,96,129],"knockout":[14],"cells":[15,40,74,84,99,161,174],"to":[16,34,43,123,169,172,207],"specifically":[17],"address":[18],"its":[19],"in":[21,25,37,46,72,110,126,213],"cell":[22,156],"cycle":[23,157],"progression":[24,158,188],"tumor":[26,39,98,160],"normal":[28,47],"cells.":[29,112],"Ablation":[30],"HDAC4":[32,70,103,113,152,182,204],"led":[33],"growth":[35,64,92],"inhibition":[36],"human":[38,48],"but":[41],"not":[42,184],"detectable":[44,63],"effects":[45],"dermal":[49],"fibroblasts":[50,60],"(NHDF)":[51],"or":[52,56,137,201],"myelopoietic":[53],"progenitors.":[54],"HDAC4-/+":[55],"HDAC4-/-":[57],"murine":[58],"embryonic":[59],"showed":[61,85],"no":[62],"defects.":[65,88,148,178],"On":[66,179],"other":[68],"hand,":[69],"RNAi":[71,130],"HeLa":[73],"produced":[75],"mitotic":[76],"arrest":[77],"followed":[78],"by":[79,102,162],"caspase-dependent":[80],"apoptosis.":[81],"Mitotically":[82],"arrested":[83],"chromosome":[86,127,146,176],"segregation":[87,105,147,177],"Even":[89],"though":[90],"both":[94],"p53-wild-type":[95],"p53-null":[97,111],"were":[100,107],"affected":[101],"ablation,":[104],"defects":[106],"observed":[108],"only":[109],"associates":[114],"with":[115,198],"PP2A-B56":[117],"regulatory":[118,139],"subunit,":[119],"which":[120,167],"is":[121,153,183,205],"known":[122],"be":[124,170],"involved":[125],"segregation,":[128],"either":[132],"structural":[134],"subunit":[135,140],"A":[136],"B56":[141],"PP2A":[143],"also":[144],"caused":[145],"conclude":[150],"that":[151,194],"required":[154,185],"for":[155,186,215],"multiple":[163],"mechanisms,":[164],"one":[165],"seems":[168],"specific":[171],"p53-deficient":[173,216],"through":[175],"contrary,":[181],"NHDF.":[190],"therefore":[192],"suggest":[193],"systemic":[195],"selective":[196],"expression":[200],"function":[202],"expected":[206],"have":[208],"a":[209],"significant":[210],"therapeutic":[211],"window,":[212],"particular,":[214],"tumors.":[217]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
