{"id":"https://openalex.org/W1981819084","doi":"https://doi.org/10.1115/sbc2012-80820","title":"Alterations in the Microstructure of the Anterior Mitral Valve Leaflet Under Physiological Stress","display_name":"Alterations in the Microstructure of the Anterior Mitral Valve Leaflet Under Physiological Stress","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W1981819084","doi":"https://doi.org/10.1115/sbc2012-80820","mag":"1981819084"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2012-80820","doi":"https://doi.org/10.1115/sbc2012-80820","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80820","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091853885","display_name":"Christopher A. Carruthers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Carruthers","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013843336","display_name":"Bryan C. Good","orcid":"https://orcid.org/0000-0002-2662-8918","observed_orcids":["https://orcid.org/0000-0002-2662-8918"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210150906","display_name":"Ri.MED","ror":"https://ror.org/05qetrn02","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210150906"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Bryan Good","raw_affiliation_strings":["Fondazione RiMED, Palermo, Italy","University of Palermo, Palermo, Italy","University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondazione RiMED, Palermo, Italy","institution_ids":["https://openalex.org/I4210150906"]},{"raw_affiliation_string":"University of Palermo, Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067981873","display_name":"Antonio D\u2019Amore","orcid":"https://orcid.org/0000-0002-3151-3170","observed_orcids":["https://orcid.org/0000-0002-3151-3170"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio D\u2019Amore","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082726401","display_name":"Jun Liao","orcid":"https://orcid.org/0000-0003-1049-5783","observed_orcids":["https://orcid.org/0000-0003-1049-5783"]},"institutions":[{"id":"https://openalex.org/I99041443","display_name":"Mississippi State University","ror":"https://ror.org/0432jq872","country_code":"US","type":"education","lineage":["https://openalex.org/I4210141039","https://openalex.org/I99041443"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Liao","raw_affiliation_strings":["Mississippi State University, Mississippi State, MS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mississippi State University, Mississippi State, MS","institution_ids":["https://openalex.org/I99041443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034728918","display_name":"Rouzbeh Amini","orcid":"https://orcid.org/0000-0003-3632-6195","observed_orcids":["https://orcid.org/0000-0003-3632-6195"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rouzbeh Amini","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088924932","display_name":"Simon C. Watkins","orcid":"https://orcid.org/0000-0003-4092-1552","observed_orcids":["https://orcid.org/0000-0003-4092-1552","https://orcid.org/0000-0003-0825-0795"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon C. Watkins","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044721030","display_name":"Michael S. Sacks","orcid":"https://orcid.org/0000-0002-2711-8370","observed_orcids":["https://orcid.org/0000-0002-2711-8370","https://orcid.org/0000-0002-3199-2204"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Sacks","raw_affiliation_strings":["University of Texas, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9895,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83284285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"227","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anterior-mitral-valve-leaflet","display_name":"anterior mitral valve leaflet","score":0.9020000100135803},{"id":"https://openalex.org/keywords/valvular-interstitial-cells","display_name":"valvular interstitial cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/physiological-load","display_name":"physiological load","score":0.5519999861717224},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-deformation","display_name":"cell deformation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/mitral-valve-disease","display_name":"mitral valve disease","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7957730293273926},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6909630298614502},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.5246286988258362},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.5096437931060791},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4839349389076233},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4517762064933777},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44336575269699097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42917516827583313},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.41890233755111694},{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.4107989966869354},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38530486822128296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3446706533432007},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32601112127304077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.242110937833786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22070881724357605},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09686651825904846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2012-80820","doi":"https://doi.org/10.1115/sbc2012-80820","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80820","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080273267","https://openalex.org/W2036760967","https://openalex.org/W2606494353","https://openalex.org/W2766538334","https://openalex.org/W2884853008","https://openalex.org/W2958087941","https://openalex.org/W4399910064","https://openalex.org/W2940026846","https://openalex.org/W2566966880","https://openalex.org/W2886969157"],"abstract_inverted_index":{"An":[0],"improved":[1],"understanding":[2],"of":[3,63,72,79,106,125],"mitral":[4],"valve":[5,16,26],"(MV)":[6],"function":[7,71,124],"remains":[8],"an":[9],"important":[10],"goal":[11,114],"for":[12,19,77],"determining":[13],"mechanisms":[14],"underlying":[15],"disease":[17],"and":[18,40,50,133],"developing":[20],"novel":[21],"therapies.":[22],"Critical":[23],"to":[24,84,116,136],"heart":[25],"tissue":[27],"homeostasis":[28],"is":[29,55,75],"the":[30,38,42,61,64,119,137],"valvular":[31],"interstitial":[32],"cells":[33],"(VICs),":[34],"which":[35,74],"reside":[36],"in":[37,101],"interstitium":[39],"maintain":[41],"extracellular":[43],"matrix":[44],"(ECM)":[45],"through":[46],"both":[47],"protein":[48],"synthesis":[49],"enzymatic":[51],"degradation":[52],"[1].":[53],"There":[54],"scant":[56],"quantitative":[57],"experimental":[58],"data":[59],"on":[60],"alterations":[62],"MV":[65,120],"fiber":[66,138],"network":[67],"reorganization":[68],"as":[69,122],"a":[70,123],"load,":[73],"critical":[76],"implementation":[78],"computational":[80],"strategies":[81],"that":[82],"attempt":[83],"link":[85],"this":[86],"meso-micro":[87],"scale":[88,93],"phenomenon.":[89],"The":[90],"observed":[91],"large":[92],"deformations":[94,132],"experienced":[95],"by":[96],"VICs":[97],"could":[98],"be":[99],"implicated":[100],"mechanotransduction":[102],"[2],":[103],"i.e.,":[104],"translation":[105],"mechanical":[107],"stimuli":[108],"into":[109],"biochemical":[110],"signals.":[111],"Consequently,":[112],"our":[113],"was":[115],"quantitatively":[117],"characterize":[118],"microstructure":[121],"physiological":[126],"loads,":[127],"including":[128],"localized":[129],"3D":[130],"VIC":[131],"relate":[134],"it":[135],"network.":[139]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}