{"id":"https://openalex.org/W1981522158","doi":"https://doi.org/10.1016/j.aquatox.2010.05.017","title":"Gene expression profiling of the fathead minnow (Pimephales promelas) neuroendocrine brain in response to pulp and paper mill effluents","display_name":"Gene expression profiling of the fathead minnow (Pimephales promelas) neuroendocrine brain in response to pulp and paper mill effluents","publication_year":2010,"publication_date":"2010-06-05","ids":{"openalex":"https://openalex.org/W1981522158","doi":"https://doi.org/10.1016/j.aquatox.2010.05.017","mag":"1981522158","pmid":"https://pubmed.ncbi.nlm.nih.gov/20561691"},"language":"en","primary_location":{"id":"doi:10.1016/j.aquatox.2010.05.017","doi":"https://doi.org/10.1016/j.aquatox.2010.05.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquatox.2010.05.017","pdf_url":null,"source":{"id":"https://openalex.org/S183233548","display_name":"Aquatic Toxicology","issn_l":"0166-445X","issn":["0166-445X","1879-1514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011467232","display_name":"Jason T. Popesku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jason T. Popesku","raw_affiliation_strings":["Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001524954","display_name":"Elvin Y.Z. Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elvin Y.Z. Tan","raw_affiliation_strings":["Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061695599","display_name":"Pierre H. Martel","orcid":"https://orcid.org/0000-0002-8763-6559","observed_orcids":["https://orcid.org/0000-0002-8763-6559"]},"institutions":[{"id":"https://openalex.org/I2800518580","display_name":"FPInnovations","ror":"https://ror.org/027cbd221","country_code":"CA","type":"funder","lineage":["https://openalex.org/I2800518580"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pierre H. Martel","raw_affiliation_strings":["FP Innovations-Paprican, Pointe-Claire, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FP Innovations-Paprican, Pointe-Claire, QC, Canada","institution_ids":["https://openalex.org/I2800518580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102140058","display_name":"Tibor G. Kovacs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800518580","display_name":"FPInnovations","ror":"https://ror.org/027cbd221","country_code":"CA","type":"funder","lineage":["https://openalex.org/I2800518580"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tibor G. Kovacs","raw_affiliation_strings":["FP Innovations-Paprican, Pointe-Claire, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FP Innovations-Paprican, Pointe-Claire, QC, Canada","institution_ids":["https://openalex.org/I2800518580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082818340","display_name":"Andrea Rowan\u2010Carroll","orcid":"https://orcid.org/0009-0008-5819-852X","observed_orcids":["https://orcid.org/0009-0008-5819-852X"]},"institutions":[{"id":"https://openalex.org/I1288894424","display_name":"Health Canada","ror":"https://ror.org/05p8nb362","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea Rowan-Carroll","raw_affiliation_strings":["Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I1288894424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044032784","display_name":"Andrew Williams","orcid":"https://orcid.org/0000-0002-7637-7686","observed_orcids":["https://orcid.org/0000-0002-7637-7686"]},"institutions":[{"id":"https://openalex.org/I1288894424","display_name":"Health Canada","ror":"https://ror.org/05p8nb362","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Williams","raw_affiliation_strings":["Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I1288894424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077375577","display_name":"Carole Lyn Yauk","orcid":"https://orcid.org/0000-0002-6725-3454","observed_orcids":["https://orcid.org/0000-0002-6725-3454"]},"institutions":[{"id":"https://openalex.org/I1288894424","display_name":"Health Canada","ror":"https://ror.org/05p8nb362","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carole Yauk","raw_affiliation_strings":["Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Health Sciences and Research Bureau, Health Canada, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I1288894424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004819710","display_name":"Vance Lionel Trudeau","orcid":"https://orcid.org/0000-0002-0845-9444","observed_orcids":["https://orcid.org/0000-0002-0845-9444"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Vance L. Trudeau","raw_affiliation_strings":["Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Advanced Research in Environmental Genomics (CAREG), Department of Biology, University of Ottawa, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004819710"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":{"value":3320,"currency":"USD","value_usd":3320},"apc_paid":null,"fwci":1.4769,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.7629717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"99","issue":"3","first_page":"379","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.1485999971628189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulp-and-paper-wastewater","display_name":"pulp mill effluent","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fathead-minnow","display_name":"fathead minnow","score":1.0},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9639999866485596},{"id":"https://openalex.org/keywords/fish-reproduction","display_name":"fish reproduction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/urotensin-i","display_name":"urotensin I","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C2776451064","wikidata":"https://www.wikidata.org/wiki/Q3333234","display_name":"Minnow","level":3,"score":0.8883782625198364},{"id":"https://openalex.org/C2993305272","wikidata":"https://www.wikidata.org/wiki/Q2700010","display_name":"Pimephales promelas","level":4,"score":0.7706899642944336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7215914726257324},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6854903101921082},{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.6232501268386841},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5886133909225464},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5631466507911682},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5333274602890015},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5100027322769165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47863641381263733},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.47613218426704407},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3426048159599304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2876591682434082},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2858317494392395},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.10332992672920227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07968616485595703},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0723370611667633}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007220","descriptor_name":"Industrial Waste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010209","descriptor_name":"Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014873","descriptor_name":"Water Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.aquatox.2010.05.017","doi":"https://doi.org/10.1016/j.aquatox.2010.05.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquatox.2010.05.017","pdf_url":null,"source":{"id":"https://openalex.org/S183233548","display_name":"Aquatic Toxicology","issn_l":"0166-445X","issn":["0166-445X","1879-1514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Toxicology","raw_type":"journal-article"},{"id":"pmid:20561691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20561691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic toxicology (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321763","display_name":"FPInnovations","ror":"https://ror.org/027cbd221"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W152428602","https://openalex.org/W1514230952","https://openalex.org/W1546357740","https://openalex.org/W1792175597","https://openalex.org/W1863858311","https://openalex.org/W1887343951","https://openalex.org/W1964889875","https://openalex.org/W1965529664","https://openalex.org/W1970013795","https://openalex.org/W1970570089","https://openalex.org/W1973398439","https://openalex.org/W1980278414","https://openalex.org/W1988304401","https://openalex.org/W1989918919","https://openalex.org/W1991379023","https://openalex.org/W2004645532","https://openalex.org/W2004716084","https://openalex.org/W2008183439","https://openalex.org/W2010282031","https://openalex.org/W2011455402","https://openalex.org/W2015710803","https://openalex.org/W2050050061","https://openalex.org/W2057395090","https://openalex.org/W2074868699","https://openalex.org/W2078452348","https://openalex.org/W2079204641","https://openalex.org/W2081941747","https://openalex.org/W2095942306","https://openalex.org/W2099589497","https://openalex.org/W2101600063","https://openalex.org/W2105029818","https://openalex.org/W2109348952","https://openalex.org/W2110065044","https://openalex.org/W2110891968","https://openalex.org/W2112127422","https://openalex.org/W2118096701","https://openalex.org/W2122954480","https://openalex.org/W2142563745","https://openalex.org/W2150422808","https://openalex.org/W2164154943","https://openalex.org/W2165981727","https://openalex.org/W2169779443","https://openalex.org/W2170778510","https://openalex.org/W2268197299","https://openalex.org/W2277781937","https://openalex.org/W2287160157","https://openalex.org/W2505846222"],"related_works":["https://openalex.org/W2044051527","https://openalex.org/W1965529664","https://openalex.org/W2566676006","https://openalex.org/W25052114","https://openalex.org/W359262174","https://openalex.org/W2132136508","https://openalex.org/W2043947002","https://openalex.org/W1995802571","https://openalex.org/W2030958648","https://openalex.org/W2137331960"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}