{"id":"https://openalex.org/W1981511368","doi":"https://doi.org/10.4161/auto.7.6.15122","title":"Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins","display_name":"Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins","publication_year":2011,"publication_date":"2011-05-24","ids":{"openalex":"https://openalex.org/W1981511368","doi":"https://doi.org/10.4161/auto.7.6.15122","mag":"1981511368","pmid":"https://pubmed.ncbi.nlm.nih.gov/21460623"},"language":"en","primary_location":{"id":"doi:10.4161/auto.7.6.15122","doi":"https://doi.org/10.4161/auto.7.6.15122","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.7.6.15122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.7.6.15122?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.7.6.15122?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015700940","display_name":"Irfan Y. Tamboli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irfan Y. Tamboli","raw_affiliation_strings":["Department of Neurology, University of Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102022011","display_name":"Nguyen T. Tien","orcid":"https://orcid.org/0000-0002-6300-0302","observed_orcids":["https://orcid.org/0000-0002-6300-0302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nguyen T. Tien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020194269","display_name":"Jochen Walter","orcid":"https://orcid.org/0000-0002-4678-2912","observed_orcids":["https://orcid.org/0000-0002-4678-2912"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jochen Walter","raw_affiliation_strings":["University of Bonn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bonn","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020194269"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"6","first_page":"645","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9079999923706055},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7409999966621399},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.949999988079071},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.46399998664855957},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.5009999871253967},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/protein-clearance","display_name":"protein clearance","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.8174877166748047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.773537278175354},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.766141414642334},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7078720927238464},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5792542099952698},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5702995657920837},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5000410079956055},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4791557192802429},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.43866121768951416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35599374771118164},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.24076446890830994},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1920437514781952},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4161/auto.7.6.15122","doi":"https://doi.org/10.4161/auto.7.6.15122","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.7.6.15122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.7.6.15122?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},{"id":"pmid:21460623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21460623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/auto.7.6.15122","doi":"https://doi.org/10.4161/auto.7.6.15122","is_oa":true,"landing_page_url":"https://doi.org/10.4161/auto.7.6.15122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/auto.7.6.15122?needAccess=true&role=button","source":{"id":"https://openalex.org/S102544370","display_name":"Autophagy","issn_l":"1554-8627","issn":["1554-8627","1554-8635"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autophagy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981511368.pdf","grobid_xml":"https://content.openalex.org/works/W1981511368.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090479627","https://openalex.org/W1998151709","https://openalex.org/W2748992879","https://openalex.org/W2125402789","https://openalex.org/W2097631517","https://openalex.org/W2017163762","https://openalex.org/W2107621349","https://openalex.org/W7134933924","https://openalex.org/W4205335396","https://openalex.org/W2034888251"],"abstract_inverted_index":{"Recent":[0],"work":[1],"from":[2],"our":[3],"laboratory":[4],"demonstrates":[5],"that":[6,62],"the":[7,13,23,49,52,63,74,79,90],"accumulation":[8,64,91],"of":[9,15,22,51,65,76,81,92,105],"sphingolipids":[10],"(SLs)":[11],"decreases":[12],"capacity":[14],"cells":[16],"to":[17],"clear":[18],"potentially":[19],"amyloidogenic":[20],"fragments":[21],"amyloid":[24,53],"precursor":[25],"protein":[26,36],"(APP)":[27],"during":[28,78],"autophagy.":[29],"APP":[30],"is":[31],"a":[32,70],"type":[33],"I":[34],"membrane":[35],"and":[37,45,58,96,99],"could":[38,88],"undergo":[39],"sequential":[40],"proteolytic":[41],"processing":[42],"by":[43],"\u03b2-":[44],"\u03b3-secretase":[46],"resulting":[47],"in":[48,73,94],"generation":[50],"\u03b2-peptide":[54],"(A\u03b2).":[55],"Genetic,":[56],"molecular":[57],"biochemical":[59],"evidence":[60],"indicates":[61],"toxic":[66],"A\u03b2":[67],"aggregates":[68],"plays":[69],"critical":[71],"role":[72],"degeneration":[75],"neurons":[77],"pathogenesis":[80],"Alzheimer":[82],"disease":[83],"(AD).":[84],"Thus,":[85],"SL":[86],"storage":[87],"promote":[89],"Ab":[93],"endosomal":[95],"lysosomal":[97],"compartments":[98],"thereby":[100],"induce":[101],"characteristic":[102],"cytopathological":[103],"changes":[104],"AD.":[106]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}