{"id":"https://openalex.org/W1981505214","doi":"https://doi.org/10.1089/adt.2006.038","title":"An Automated High Throughput Liquid Chromatography\u2013Mass Spectrometry Process to Assess the Metabolic Stability of Drug Candidates","display_name":"An Automated High Throughput Liquid Chromatography\u2013Mass Spectrometry Process to Assess the Metabolic Stability of Drug Candidates","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W1981505214","doi":"https://doi.org/10.1089/adt.2006.038","mag":"1981505214","pmid":"https://pubmed.ncbi.nlm.nih.gov/17477833"},"language":"en","primary_location":{"id":"doi:10.1089/adt.2006.038","doi":"https://doi.org/10.1089/adt.2006.038","is_oa":false,"landing_page_url":"https://doi.org/10.1089/adt.2006.038","pdf_url":null,"source":{"id":"https://openalex.org/S76283439","display_name":"Assay and Drug Development Technologies","issn_l":"1540-658X","issn":["1540-658X","1557-8127"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASSAY and Drug Development Technologies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039501181","display_name":"Dieter M. Drexler","orcid":"https://orcid.org/0000-0003-2877-7973","observed_orcids":["https://orcid.org/0000-0003-2877-7973"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dieter M. Drexler","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT 06492, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT 06492, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039122189","display_name":"James V. Belcastro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James V. Belcastro","raw_affiliation_strings":["Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007316","display_name":"Kenneth E.J. Dickinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Dickinson","raw_affiliation_strings":["Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111537829","display_name":"Kurt J. Edinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt J. Edinger","raw_affiliation_strings":["Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013540666","display_name":"Serhiy Y. Hnatyshyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serhiy Y. Hnatyshyn","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010234075","display_name":"Jonathan L. Josephs","orcid":"https://orcid.org/0000-0002-0620-8086","observed_orcids":["https://orcid.org/0000-0002-0620-8086"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan L. Josephs","raw_affiliation_strings":["Biotransformation, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotransformation, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026533747","display_name":"Robert A. Langish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Langish","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077899342","display_name":"Colleen A. McNaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen A. McNaney","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110490519","display_name":"Kenneth S. Santone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth S. Santone","raw_affiliation_strings":["Metabolism and Pharmacokinetics\u2014Discovery Support, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism and Pharmacokinetics\u2014Discovery Support, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012096877","display_name":"Petia A. Shipkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Petia A. Shipkova","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Pennington, NJ","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060596849","display_name":"Adrienne A. Tymiak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne A. Tymiak","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041653454","display_name":"Tatyana A. Zvyaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatyana A. Zvyaga","raw_affiliation_strings":["Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences\u2014Lead Discovery and Profiling, Applied Biotechnologies, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, CT","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mark Sanders","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Sanders","raw_affiliation_strings":["Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Princeton, NJ","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210091812"],"apc_list":null,"apc_paid":null,"fwci":4.0461,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.94023432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"2","first_page":"247","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8179000020027161,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.07729999721050262,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.5839999914169312},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8759999871253967},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.8159999847412109},{"id":"https://openalex.org/keywords/robotic-liquid-handling","display_name":"robotic liquid handling","score":0.5920000076293945},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"collision-induced dissociation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6770414710044861},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6491326093673706},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.6192253232002258},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.6116912364959717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.537081241607666},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47291311621665955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26857444643974304},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009251","descriptor_name":"NADPH-Ferrihemoprotein Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012371","descriptor_name":"Robotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/adt.2006.038","doi":"https://doi.org/10.1089/adt.2006.038","is_oa":false,"landing_page_url":"https://doi.org/10.1089/adt.2006.038","pdf_url":null,"source":{"id":"https://openalex.org/S76283439","display_name":"Assay and Drug Development Technologies","issn_l":"1540-658X","issn":["1540-658X","1557-8127"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASSAY and Drug Development Technologies","raw_type":"journal-article"},{"id":"pmid:17477833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17477833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Assay and drug development technologies","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W185719940","https://openalex.org/W1502157816","https://openalex.org/W1970559437","https://openalex.org/W1978154072","https://openalex.org/W1986404730","https://openalex.org/W1990508575","https://openalex.org/W1996242082","https://openalex.org/W2000457665","https://openalex.org/W2019315584","https://openalex.org/W2020628904","https://openalex.org/W2027509910","https://openalex.org/W2065252256","https://openalex.org/W2067514904","https://openalex.org/W2071183229","https://openalex.org/W2074820488","https://openalex.org/W2088449942","https://openalex.org/W2091070913","https://openalex.org/W2095380378","https://openalex.org/W2120133588","https://openalex.org/W2127091902","https://openalex.org/W2128101774","https://openalex.org/W2135945518","https://openalex.org/W2144465276","https://openalex.org/W2162739847","https://openalex.org/W2163689256","https://openalex.org/W2169426479","https://openalex.org/W2236622920","https://openalex.org/W2356379002","https://openalex.org/W2487159467","https://openalex.org/W4406065843"],"related_works":["https://openalex.org/W2055175185","https://openalex.org/W2464374827","https://openalex.org/W2067514904","https://openalex.org/W1978154072","https://openalex.org/W2001342472","https://openalex.org/W2123301394","https://openalex.org/W2488689029","https://openalex.org/W4392367568","https://openalex.org/W2169426479","https://openalex.org/W2126466225"],"abstract_inverted_index":{"An":[0],"automated":[1,183],"high":[2,141],"throughput":[3],"process,":[4],"termed":[5,178],"the":[6,15,67,158,232,257,260],"MetFast":[7,261],"assay,":[8,262],"is":[9,149,180,256],"described":[10],"to":[11,65,113,138,151],"assess":[12,84],"in":[13,238],"vitro":[14],"general":[16],"microsomal":[17],"cytochrome":[18],"P450":[19],"beta-nicotinamide":[20],"adenine":[21],"dinucleotide":[22],"phosphate-mediated":[23],"first-pass":[24],"metabolic":[25,163,247,264],"stability":[26,164,248,265],"of":[27,69,79,87,162,197,205,234,259],"potential":[28],"drug":[29],"candidates":[30],"as":[31],"a":[32,41,73,93],"utility":[33],"for":[34,157,182,210,217],"pharmaceutical":[35],"profiling.":[36],"Utilizing":[37],"robotic":[38],"protocols":[39],"with":[40,48,132],"multiprobe":[42],"liquid":[43,60],"handler,":[44],"compounds":[45,90,104,131,270],"are":[46,55,105,135,271],"incubated":[47],"liver":[49],"microsomes":[50],"from":[51,267],"different":[52],"species.":[53],"Samples":[54],"then":[56],"analyzed":[57,107],"by":[58,91,108,166],"in-line":[59],"chromatography":[61],"(LC)-mass":[62],"spectrometry":[63],"(MS)":[64],"determine":[66,114],"amount":[68],"compound":[70],"remaining":[71],"after":[72],"certain":[74],"time,":[75],"which":[76],"allows":[77],"calculation":[78],"metabolism":[80],"rates.":[81],"To":[82],"quantitatively":[83],"large":[85],"numbers":[86],"structurally":[88,251],"diverse":[89,252],"LC-MS,":[92],"strategy":[94],"based":[95],"on":[96,250],"an":[97,239],"iterative":[98],"two-step":[99],"process":[100,241],"was":[101],"devised.":[102],"Initially":[103],"qualitatively":[106],"LC-ultraviolet":[109],"(UV)/MS":[110],"(step":[111,168],"1)":[112],"purity":[115,134],"(UV":[116],"detection)":[117],"and":[118,129,173,185,192,219,231,263],"structural":[119],"integrity":[120],"(MS":[121],"detection).":[122],"This":[123],"step":[124],"ensures":[125],"that":[126,242],"only":[127],"correct":[128],"verified":[130],"sufficient":[133],"being":[136],"assayed":[137],"obtain":[139],"reproducible":[140,245],"data":[142,175,190,249,266],"quality.":[143],"In":[144],"addition,":[145],"all":[146],"necessary":[147],"information":[148],"gathered":[150],"automatically":[152],"generate":[153],"specific":[154],"quantitative":[155,186,221],"methods":[156],"subsequent":[159],"bioanalytical":[160],"analysis":[161,188],"samples":[165],"LC-UV/MS":[167],"2).":[169],"In-house-developed,":[170],"highly":[171],"flexible":[172],"sophisticated":[174],"management":[176],"software,":[177],"SmartReport,":[179],"utilized":[181,216],"qualitative":[184],"LC-MS":[187],"set-up,":[189],"processing,":[191],"results":[193],"reporting.":[194],"The":[195],"integration":[196],"key":[198],"aspects,":[199],"inherent":[200],"\"universal\"":[201],"collision-induced":[202],"dissociation":[203],"settings":[204],"ion":[206],"trap":[207],"mass":[208,212],"spectrometers":[209],"tandem":[211],"spectrometric":[213],"scan":[214],"functions":[215],"compound-specific":[218],"sensitive":[220],"MS":[222,228],"methods,":[223],"generic":[224,227],"fast-LC":[225],"conditions,":[226],"instrument":[229],"settings,":[230],"functionality":[233],"SmartReport":[235],"software":[236],"resulted":[237],"analytical":[240],"routinely":[243],"provides":[244],"high-quality":[246],"compounds.":[253],"Described":[254],"here":[255],"setup":[258],"assay":[268],"validation":[269],"given.":[272]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}