{"id":"https://openalex.org/W1981307361","doi":"https://doi.org/10.14374/hfs.2013.21.1.111","title":"Acute Toxicity Study on Oryeong-san in Mice","display_name":"Acute Toxicity Study on Oryeong-san in Mice","publication_year":2013,"publication_date":"2013-06-30","ids":{"openalex":"https://openalex.org/W1981307361","doi":"https://doi.org/10.14374/hfs.2013.21.1.111","mag":"1981307361"},"language":"en","primary_location":{"id":"doi:10.14374/hfs.2013.21.1.111","doi":"https://doi.org/10.14374/hfs.2013.21.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2013.21.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201319953222048.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://koreascience.or.kr:80/article/JAKO201319953222048.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067953518","display_name":"Hwayong Park","orcid":"https://orcid.org/0000-0002-3352-0980","observed_orcids":["https://orcid.org/0000-0002-3352-0980"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwayong Park","raw_affiliation_strings":["KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016137020","display_name":"Youn\u2010Hwan Hwang","orcid":"https://orcid.org/0000-0002-4959-2436","observed_orcids":["https://orcid.org/0000-0002-4959-2436"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youn-Hwan Hwang","raw_affiliation_strings":["KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112038444","display_name":"Jeong-Ho Ha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong-Ho Ha","raw_affiliation_strings":["KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009077866","display_name":"Kiyoun Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kiyoun Jung","raw_affiliation_strings":["KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM-Based Herbal Drug Research Group , Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040824493","display_name":"Jin Yeul","orcid":"https://orcid.org/0000-0001-8796-0394","observed_orcids":["https://orcid.org/0000-0001-8796-0394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Yeul Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4025,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.68612822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"1","first_page":"111","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.847000002861023},{"id":"https://openalex.org/keywords/median-lethal-dose","display_name":"median lethal dose","score":0.8069999814033508},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.49799999594688416},{"id":"https://openalex.org/keywords/herbal-formula","display_name":"herbal formula","score":0.49799999594688416},{"id":"https://openalex.org/keywords/cd-1-mice","display_name":"ICR mice","score":0.6110000014305115},{"id":"https://openalex.org/keywords/blood-chemistry","display_name":"serum biochemistry","score":0.8050000071525574},{"id":"https://openalex.org/keywords/organ-weight","display_name":"organ weight","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8500766158103943},{"id":"https://openalex.org/C2776845205","wikidata":"https://www.wikidata.org/wiki/Q1269399","display_name":"Dysuria","level":3,"score":0.8108758330345154},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7756677269935608},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.6528135538101196},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4838249087333679},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.47550803422927856},{"id":"https://openalex.org/C2778713406","wikidata":"https://www.wikidata.org/wiki/Q474187","display_name":"Thirst","level":2,"score":0.4499052166938782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4079890251159668},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3546430170536041},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.08361214399337769}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14374/hfs.2013.21.1.111","doi":"https://doi.org/10.14374/hfs.2013.21.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2013.21.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201319953222048.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14374/hfs.2013.21.1.111","doi":"https://doi.org/10.14374/hfs.2013.21.1.111","is_oa":true,"landing_page_url":"https://doi.org/10.14374/hfs.2013.21.1.111","pdf_url":"http://koreascience.or.kr:80/article/JAKO201319953222048.pdf","source":{"id":"https://openalex.org/S4306512052","display_name":"Herbal Formula Science","issn_l":"1229-1218","issn":["1229-1218"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Herbal Formula Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981307361.pdf","grobid_xml":"https://content.openalex.org/works/W1981307361.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1978077948","https://openalex.org/W1982407010","https://openalex.org/W1996099710","https://openalex.org/W1999774709","https://openalex.org/W2007721348","https://openalex.org/W2009745420","https://openalex.org/W2011550183","https://openalex.org/W2033373979","https://openalex.org/W2058535066","https://openalex.org/W3150060628"],"related_works":["https://openalex.org/W1862713320","https://openalex.org/W2012820372","https://openalex.org/W863223257","https://openalex.org/W2246546068","https://openalex.org/W2962086780","https://openalex.org/W1874235376","https://openalex.org/W338839363","https://openalex.org/W2038867999","https://openalex.org/W773754368","https://openalex.org/W2884042373"],"abstract_inverted_index":{"Objectives":[0],":":[1,45,86,119],"Traditional":[2],"medicine":[3],"Oryeong-san":[4],"(ORS)":[5],"has":[6],"been":[7],"prescribed":[8],"for":[9],"a":[10],"long":[11],"time":[12],"to":[13,50,133],"treat":[14],"light":[15],"fever,":[16],"thirst,":[17],"dysuria,":[18],"and":[19,26,40,54,69,74,77,91,112,124,128,141],"accompanying":[20],"edema.":[21],"However,":[22],"the":[23,36],"acute":[24,38,52],"toxicity":[25,39,53],"safety":[27,41,55],"were":[28,48,72,81,116],"not":[29],"reported.":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"evaluated":[35],"potent":[37],"of":[42,59,64,100],"ORS.":[43,65,101],"Methods":[44],"ICR":[46,143],"mice":[47],"used":[49],"evaluate":[51],"by":[56,98],"oral":[57],"administration":[58,99],"0,":[60],"500,":[61],"1,000,":[62],"2,000mg/kg":[63],"Mortality,":[66],"body":[67],"weight,":[68],"clinical":[70,96],"symptoms":[71,97],"observed,":[73],"organ":[75,110],"weight":[76,111],"blood":[78,113],"biochemical":[79,114],"parameters":[80,115],"analyzed":[82],"after":[83],"necropsy.":[84],"Results":[85],"We":[87],"found":[88],"no":[89,92,106],"mortality":[90],"toxic":[93],"or":[94],"abnormal":[95],"Comparing":[102],"with":[103],"control":[104],"group,":[105],"significant":[107],"alterations":[108],"in":[109,138],"observed.":[117],"Conclusions":[118],"ORS":[120],"recognized":[121],"as":[122],"safe":[123],"non-toxic":[125],"medicinal":[126],"material,":[127],"median":[129],"lethal":[130],"dose":[131],"considered":[132],"be":[134],"over":[135],"2,000":[136],"mg/kg":[137],"both":[139],"male":[140],"female":[142],"mice.":[144]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2016-06-24T00:00:00"}