{"id":"https://openalex.org/W1981277668","doi":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","title":"Systemic Diseases and Their Treatments in the Elderly: Impact on Oral Health","display_name":"Systemic Diseases and Their Treatments in the Elderly: Impact on Oral Health","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1981277668","doi":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","mag":"1981277668","pmid":"https://pubmed.ncbi.nlm.nih.gov/11243049"},"language":"en","primary_location":{"id":"doi:10.1111/j.1752-7325.2000.tb03337.x","doi":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","pdf_url":null,"source":{"id":"https://openalex.org/S18039248","display_name":"Journal of Public Health Dentistry","issn_l":"0022-4006","issn":["0022-4006","1752-7325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Public Health Dentistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067425278","display_name":"Elisa M. Ghezzi","orcid":"https://orcid.org/0009-0002-9354-2660","observed_orcids":["https://orcid.org/0009-0002-9354-2660"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elisa M. Ghezzi","raw_affiliation_strings":["University of North Carolina at Chapel Hill, School of Dentistry, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, School of Dentistry, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026172473","display_name":"Jonathan A. Ship","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan A. Ship","raw_affiliation_strings":["Send correspondence and reprint requests to Dr. Ship, Department of Oral Medicine, Bluestone Center for Clinical Research, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010\u20134086. E-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Send correspondence and reprint requests to Dr. Ship, Department of Oral Medicine, Bluestone Center for Clinical Research, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010\u20134086. E-mail:","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026172473","https://openalex.org/A5067425278"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I57206974"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":0.526,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.46590909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"60","issue":"4","first_page":"289","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-health","display_name":"oral health","score":0.8679999709129333},{"id":"https://openalex.org/keywords/successful-aging","display_name":"successful aging","score":0.8669999837875366},{"id":"https://openalex.org/keywords/compression-of-morbidity","display_name":"compression of morbidity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.628000020980835},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8119999766349792},{"id":"https://openalex.org/keywords/heart-disease","display_name":"heart disease","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.9300000071525574},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/septicemia","display_name":"septicemia","score":0.7009999752044678},{"id":"https://openalex.org/keywords/oral-manifestations","display_name":"oral manifestations","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9009017944335938},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6792574524879456},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6332720518112183},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5858850479125977},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5031706690788269},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4857202172279358},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.47357046604156494},{"id":"https://openalex.org/C13774568","wikidata":"https://www.wikidata.org/wiki/Q439112","display_name":"Population ageing","level":3,"score":0.4327772855758667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18368685245513916},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10585471987724304},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.08490884304046631},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009059","descriptor_name":"Mouth Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009059","descriptor_name":"Mouth Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009059","descriptor_name":"Mouth Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1752-7325.2000.tb03337.x","doi":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1752-7325.2000.tb03337.x","pdf_url":null,"source":{"id":"https://openalex.org/S18039248","display_name":"Journal of Public Health Dentistry","issn_l":"0022-4006","issn":["0022-4006","1752-7325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Public Health Dentistry","raw_type":"journal-article"},{"id":"pmid:11243049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11243049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of public health dentistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W53870914","https://openalex.org/W125885132","https://openalex.org/W651763111","https://openalex.org/W1490756559","https://openalex.org/W1965943364","https://openalex.org/W1969648928","https://openalex.org/W1983804375","https://openalex.org/W1992343103","https://openalex.org/W2000669151","https://openalex.org/W2002735721","https://openalex.org/W2003211489","https://openalex.org/W2005583346","https://openalex.org/W2007405527","https://openalex.org/W2012345522","https://openalex.org/W2015112192","https://openalex.org/W2017287740","https://openalex.org/W2021476567","https://openalex.org/W2022774434","https://openalex.org/W2023115254","https://openalex.org/W2028831887","https://openalex.org/W2032337411","https://openalex.org/W2068776651","https://openalex.org/W2074185541","https://openalex.org/W2078156320","https://openalex.org/W2081950763","https://openalex.org/W2082272941","https://openalex.org/W2082917888","https://openalex.org/W2085658568","https://openalex.org/W2090541270","https://openalex.org/W2093020541","https://openalex.org/W2116742631","https://openalex.org/W2121841518","https://openalex.org/W2140972965","https://openalex.org/W2147682536","https://openalex.org/W2174186379","https://openalex.org/W2175404989","https://openalex.org/W2176871231","https://openalex.org/W2223169290","https://openalex.org/W2315953212","https://openalex.org/W2316030866","https://openalex.org/W2324484927","https://openalex.org/W2404520868","https://openalex.org/W2603578809","https://openalex.org/W4211161764","https://openalex.org/W4293242754","https://openalex.org/W4299505432"],"related_works":["https://openalex.org/W2441273399","https://openalex.org/W4320926900","https://openalex.org/W3140452484","https://openalex.org/W2515506058","https://openalex.org/W2038341587","https://openalex.org/W7196932766","https://openalex.org/W2789225760","https://openalex.org/W2884076076","https://openalex.org/W6949542016","https://openalex.org/W2336629428"],"abstract_inverted_index":{"The":[0],"lifespan":[1],"of":[2,42,50,59,79,108,130,143,146,185,187,195],"the":[3,9,64,80,106,144,183,193],"US":[4],"population":[5,189],"is":[6,16,154],"increasing,":[7],"with":[8,28,125,166],"elderly":[10],"desiring":[11],"successful":[12,46,196],"aging.":[13,197],"This":[14,61],"goal":[15],"jeopardized":[17],"as":[18],"multiple":[19],"systemic":[20,32,67,147],"conditions":[21,118],"and":[22,33,36,57,71,100,105,110,138,149,162,175,190],"their":[23],"treatments":[24],"become":[25],"more":[26],"prevalent":[27],"age,":[29],"causing":[30,69],"impaired":[31],"oral":[34,136,152,177],"health":[35,153,178],"influencing":[37],"an":[38],"older":[39,164],"person's":[40],"quality":[41,184],"life.":[43],"To":[44],"obtain":[45],"aging,":[47],"a":[48,170],"compression":[49],"morbidity":[51,70],"must":[52],"be":[53],"obtained":[54],"through":[55],"prevention":[56],"management":[58],"disease.":[60],"paper":[62],"describes":[63],"most":[65],"common":[66],"diseases":[68,78,148],"mortality":[72],"in":[73,192],"persons":[74],"aged":[75],"65+":[76],"years:":[77],"heart,":[81],"malignant":[82],"neoplasms,":[83],"cerebrovascular":[84],"diseases,":[85,98],"chronic":[86],"obstructive":[87],"pulmonary":[88],"disease,":[89,96],"pneumonia,":[90],"influenza,":[91],"diabetes":[92],"mellitus,":[93],"trauma,":[94],"Alzheimer's":[95],"renal":[97],"septicemia,":[99],"liver":[101],"diseases.":[102],"Disease":[103],"prevalence":[104],"impact":[107,145],"medications":[109],"other":[111],"therapeutic":[112],"measures":[113],"used":[114],"to":[115,159],"treat":[116,161],"these":[117,131,167],"are":[119,123],"discussed.":[120],"Oral":[121],"sequelae":[122],"reviewed":[124],"guidelines":[126],"for":[127,135,156],"early":[128,173],"detection":[129,174],"deleterious":[132],"consequences,":[133],"considerations":[134],"treatment,":[137],"patient":[139],"management.":[140],"An":[141],"understanding":[142],"treatment":[150],"on":[151,172],"imperative":[155],"dental":[157],"practitioners":[158],"appropriately":[160],"manage":[163],"patients":[165],"conditions.":[168],"With":[169],"focus":[171],"prevention,":[176],"care":[179],"providers":[180],"can":[181],"improve":[182],"life":[186],"this":[188],"aid":[191],"attainment":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}