{"id":"https://openalex.org/W1981196442","doi":"https://doi.org/10.1359/jbmr.041009","title":"Fluid Shear-Induced ATP Secretion Mediates Prostaglandin Release in MC3T3-E1 Osteoblasts","display_name":"Fluid Shear-Induced ATP Secretion Mediates Prostaglandin Release in MC3T3-E1 Osteoblasts","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W1981196442","doi":"https://doi.org/10.1359/jbmr.041009","mag":"1981196442","pmid":"https://pubmed.ncbi.nlm.nih.gov/15619668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2929123"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.041009","doi":"https://doi.org/10.1359/jbmr.041009","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.041009","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/JBMR.041009","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1981196442"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/JBMR.041009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075094625","display_name":"Damian C. Genetos","orcid":"https://orcid.org/0000-0002-8599-2867","observed_orcids":["https://orcid.org/0000-0002-8599-2867"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Damian C Genetos","raw_affiliation_strings":["Departments of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001272490","display_name":"Derik J Geist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derik J Geist","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051747497","display_name":"Dawei Liu","orcid":"https://orcid.org/0000-0003-4592-8358","observed_orcids":["https://orcid.org/0000-0003-4592-8358"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawei Liu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007737311","display_name":"Henry J. Donahue","orcid":"https://orcid.org/0000-0002-9238-4157","observed_orcids":["https://orcid.org/0000-0002-9238-4157"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry J Donahue","raw_affiliation_strings":["Departments of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA","Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088184269","display_name":"Randall L. Duncan","orcid":"https://orcid.org/0000-0001-5733-6603","observed_orcids":["https://orcid.org/0000-0001-5733-6603"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randall L Duncan","raw_affiliation_strings":["Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088184269"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":9.1505,"has_fulltext":true,"cited_by_count":286,"citation_normalized_percentile":{"value":0.99701344,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"41","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluid-shear","display_name":"fluid shear","score":0.9480000138282776},{"id":"https://openalex.org/keywords/atp-release","display_name":"ATP release","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8190000057220459},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vesicle-exocytosis","display_name":"vesicle exocytosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/p2-purinergic-receptors","display_name":"purinergic P2 receptors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.8880000114440918},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7279999852180481},{"id":"https://openalex.org/keywords/apyrase","display_name":"apyrase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/mc3t3-e1-cells","display_name":"MC3T3-E1 cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bone-mechanobiology","display_name":"bone mechanobiology","score":0.5860000252723694},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.6589999794960022},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7877727746963501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5169610381126404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44139882922172546},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.440645307302475},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4310113191604614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40195372700691223},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3741663098335266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23614931106567383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2275925576686859}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001081","descriptor_name":"Apyrase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015759","descriptor_name":"Ionomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058307","descriptor_name":"Receptors, Prostaglandin E, EP2 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1359/jbmr.041009","doi":"https://doi.org/10.1359/jbmr.041009","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.041009","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/JBMR.041009","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"doi:10.1359/jbmr.2005.20.1.41","doi":"https://doi.org/10.1359/jbmr.2005.20.1.41","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.2005.20.1.41","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:15619668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15619668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2929123","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2929123/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Bone Miner Res","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/55586","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/55586","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/8c8d216a-cbf3-4d5a-92db-bfd73cb77bf9/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.944.9283","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.944.9283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Damian_Genetos/publication/8110353_Fluid_ShearInduced_ATP_Secretion_Mediates_Prostaglandin_Release_in_MC3T3E1_Osteoblasts/links/09e4150327a7294b6d000000.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.948.7886","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.948.7886","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Damian_Genetos/publication/8110353_Fluid_shear-induced_ATP_secretion_mediates_prostaglandin_release_in_MC3T3-E1_osteoblasts/links/09e4150327a7294b6d000000.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1359/jbmr.041009","doi":"https://doi.org/10.1359/jbmr.041009","is_oa":true,"landing_page_url":"https://doi.org/10.1359/jbmr.041009","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/JBMR.041009","source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1566499697","display_name":null,"funder_award_id":"13087-09","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G1919226730","display_name":"MECHANOTRANSDUCTION IN BONE","funder_award_id":"P01AR045218","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2855993209","display_name":"PTH Reduces the Mechanical Threshold in Osteoblasts","funder_award_id":"R01DK058246","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5488429319","display_name":"Issues of Mechanosensitivity in Osteoblasts","funder_award_id":"R01AR043222","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5583944748","display_name":"ACTIVATION, ADAPTATION AND RESTORATION OF THE MECH ANICAL RESPONSE OF OSTEOBLASTS TO FLUID SHEAR/STU","funder_award_id":"NGT550366","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G7021050798","display_name":"Gap Junction and Bone Cell Responses to Physical Signals","funder_award_id":"R01AG013087","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981196442.pdf","grobid_xml":"https://content.openalex.org/works/W1981196442.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W202834474","https://openalex.org/W1532386517","https://openalex.org/W1873184289","https://openalex.org/W1875886495","https://openalex.org/W1884900523","https://openalex.org/W1932241391","https://openalex.org/W1978252089","https://openalex.org/W1981919734","https://openalex.org/W1986746924","https://openalex.org/W1987577114","https://openalex.org/W1988622369","https://openalex.org/W2009462543","https://openalex.org/W2017909062","https://openalex.org/W2023201005","https://openalex.org/W2027712657","https://openalex.org/W2027765902","https://openalex.org/W2030331927","https://openalex.org/W2031070373","https://openalex.org/W2044930326","https://openalex.org/W2051792551","https://openalex.org/W2055407120","https://openalex.org/W2063553561","https://openalex.org/W2066227639","https://openalex.org/W2066628016","https://openalex.org/W2070776129","https://openalex.org/W2081257648","https://openalex.org/W2084535455","https://openalex.org/W2088602091","https://openalex.org/W2090043788","https://openalex.org/W2091042230","https://openalex.org/W2091824151","https://openalex.org/W2096925272","https://openalex.org/W2098759244","https://openalex.org/W2099279074","https://openalex.org/W2111395353","https://openalex.org/W2115293226","https://openalex.org/W2119892103","https://openalex.org/W2135343497","https://openalex.org/W2137780990","https://openalex.org/W2138599948","https://openalex.org/W2140042507","https://openalex.org/W2143091157","https://openalex.org/W2157909882","https://openalex.org/W2163414758","https://openalex.org/W2181400332","https://openalex.org/W2189467740","https://openalex.org/W2261511021","https://openalex.org/W2264664535","https://openalex.org/W2269458787","https://openalex.org/W2271816486","https://openalex.org/W2345043532"],"related_works":["https://openalex.org/W1884900523","https://openalex.org/W2330395202","https://openalex.org/W1986393841","https://openalex.org/W2158144686","https://openalex.org/W2083920483","https://openalex.org/W2085989796","https://openalex.org/W2101299206","https://openalex.org/W2610288133","https://openalex.org/W1989866518","https://openalex.org/W2055532277"],"abstract_inverted_index":{"UNLABELLED:":[0],"ATP":[1,24,48,114,155,204,244,253,259,288,307,340,352],"is":[2,88],"rapidly":[3],"released":[4],"from":[5,96,268],"osteoblasts":[6,67],"in":[7,17,62,66,78,86,184,203,255,261,286,313,336],"response":[8,262],"to":[9,106,136,138,143,263,266,331],"mechanical":[10],"load.":[11],"We":[12],"examined":[13],"the":[14,38,72,89,108,117,158,185,189,192,231],"mechanisms":[15,119],"involved":[16],"this":[18,84,122],"release":[19,25,99,115,156,205,254,260,270],"and":[20,31,116,141,175,182,271],"established":[21],"that":[22,68,346],"shear-induced":[23,52,97,243,311],"was":[26,32,104,161],"mediated":[27],"through":[28,40,230,273],"vesicular":[29,176,269,339],"fusion":[30],"dependent":[33],"on":[34,113,131,251],"Ca2+":[35,43,234,333],"entry":[36,229,334],"into":[37,157],"cell":[39],"L-type":[41,232],"voltage-sensitive":[42,233],"channels.":[44],"Degradation":[45,304],"of":[46,71,91,100,110,168,191,224,227,292,305,324],"secreted":[47,351],"by":[49,350],"apyrase":[50,309],"prevented":[51,284,310],"PGE2":[53],"release.":[54,123,245,317,341,356],"INTRODUCTION:":[55],"Fluid":[56,197],"shear":[57,112,181,198,264,328],"induces":[58],"a":[59,150,164,200,321],"rapid":[60],"rise":[61],"intracellular":[63],"calcium":[64,228],"([Ca2+]i)":[65],"mediates":[69,353],"many":[70],"cellular":[73],"responses":[74],"associated":[75,120],"with":[76,121,207,237,278,295,308],"mechanotransduction":[77,325],"bone.":[79],"A":[80],"potential":[81],"mechanism":[82],"for":[83,188],"increase":[85,202],"[Ca2+]i":[87],"activation":[90,349],"purinergic":[92],"(P2)":[93],"receptors":[94],"resulting":[95],"extracellular":[98,306],"ATP.":[101],"This":[102],"study":[103],"designed":[105],"determine":[107],"effects":[109],"fluid":[111,147,327],"possible":[118],"MATERIALS":[124],"AND":[125,195],"METHODS:":[126],"MC3T3-E1":[127,209],"preosteoblasts":[128],"were":[129,178],"plated":[130],"type":[132],"I":[133],"collagen,":[134],"allowed":[135],"proliferate":[137],"90%":[139],"confluency,":[140],"subjected":[142],"12":[144],"dynes/cm2":[145],"laminar":[146],"flow":[148,153,159,186],"using":[149,163],"parallel":[151],"plate":[152],"chamber.":[154],"media":[160],"measured":[162],"luciferin/luciferase":[165],"assay.":[166],"Inhibitors":[167],"channels,":[169],"gap":[170,274,293],"junctional":[171],"intercellular":[172],"communication":[173],"(GJIC),":[174],"formation":[177],"added":[179],"before":[180],"maintained":[183],"medium":[187],"duration":[190],"experiment.":[193],"RESULTS":[194],"CONCLUSIONS:":[196],"produced":[199],"transient":[201],"compared":[206],"static":[208,256],"cells":[210],"(59.8":[211],"+/-":[212,216],"15.7":[213],"versus":[214],"6.2":[215],"1.8":[217],"nM,":[218],"respectively),":[219],"peaking":[220],"within":[221],"1":[222],"minute":[223],"onset.":[225],"Inhibition":[226],"channel":[235],"(L-VSCC)":[236],"nifedipine":[238],"or":[239,282,299],"verapamil":[240],"significantly":[241],"attenuated":[242],"Channel":[246],"inhibition":[247,291],"had":[248],"no":[249],"effect":[250],"basal":[252],"cells.":[257],"Ca(2+)-dependent":[258],"seemed":[265],"result":[267],"not":[272],"hemichannels.":[275],"Vesicle":[276],"disruption":[277],"N-ethylmaleimide,":[279],"brefeldin":[280],"A,":[281],"monensin":[283],"increases":[285,312],"flow-induced":[287,354],"release,":[289],"whereas":[290],"hemichannels":[294],"either":[296],"18alpha-glycyrrhetinic":[297],"acid":[298,301],"18beta-glycyrrhetinic":[300],"did":[302],"not.":[303],"prostaglandin":[314,355],"E2":[315],"(PGE2)":[316],"These":[318],"data":[319,344],"suggest":[320,345],"time":[322],"line":[323],"wherein":[326],"activates":[329],"L-VSCCs":[330],"promote":[332],"that,":[335],"turn,":[337],"stimulates":[338],"Furthermore,":[342],"these":[343],"P2":[347],"receptor":[348]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
