{"id":"https://openalex.org/W1981195281","doi":"https://doi.org/10.2174/1876532700901010005","title":"Mitochondrial Superoxide Dismutase Activity in Amyotrophic Lateral Sclerosis","display_name":"Mitochondrial Superoxide Dismutase Activity in Amyotrophic Lateral Sclerosis","publication_year":2009,"publication_date":"2009-04-02","ids":{"openalex":"https://openalex.org/W1981195281","doi":"https://doi.org/10.2174/1876532700901010005","mag":"1981195281"},"language":"en","primary_location":{"id":"doi:10.2174/1876532700901010005","doi":"https://doi.org/10.2174/1876532700901010005","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1876532700901010005","pdf_url":"http://benthamopen.com/contents/pdf/TOSPINEJ/TOSPINEJ-1-5.pdf","source":{"id":"https://openalex.org/S134405079","display_name":"The Open Spine Journal","issn_l":"1876-5327","issn":["1876-5327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Spine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://benthamopen.com/contents/pdf/TOSPINEJ/TOSPINEJ-1-5.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064320499","display_name":"Pilar Larrod\u00e9","orcid":"https://orcid.org/0000-0002-5413-1431","observed_orcids":["https://orcid.org/0000-0002-5413-1431"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]},{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Larrode","raw_affiliation_strings":["Neurology Department, Lozano-Blesa Clinical Hospital, Zaragoza, Spain","Biology Department, Zaragoza University Sciences Faculty, Spain","Neurology Department, Miguel-Servet Hospital, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Lozano-Blesa Clinical Hospital, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]},{"raw_affiliation_string":"Biology Department, Zaragoza University Sciences Faculty, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Neurology Department, Miguel-Servet Hospital, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025231444","display_name":"Pedro I\u00f1arrea","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro Inarrea","raw_affiliation_strings":["Biology Department , Zaragoza University Sciences Faculty , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department , Zaragoza University Sciences Faculty , Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032264660","display_name":"Jose Luis Capablo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose L. Capablo","raw_affiliation_strings":["Biology Department , Zaragoza University Sciences Faculty , Spain","Neurology Department , Miguel-Servet Hospital , Zaragoza , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department , Zaragoza University Sciences Faculty , Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Neurology Department , Miguel-Servet Hospital , Zaragoza , Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109854440","display_name":"Cristina \u00cd\u00f1iguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]},{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Iniguez","raw_affiliation_strings":["Neurology Department, Lozano-Blesa Clinical Hospital, Zaragoza, Spain","Biology Department, Zaragoza University Sciences Faculty, Spain","Neurology Department, Miguel-Servet Hospital, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Department, Lozano-Blesa Clinical Hospital, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]},{"raw_affiliation_string":"Biology Department, Zaragoza University Sciences Faculty, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Neurology Department, Miguel-Servet Hospital, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013972889","display_name":"J.R. Ara","orcid":"https://orcid.org/0000-0002-9788-2083","observed_orcids":["https://orcid.org/0000-0002-9788-2083"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose R. Ara","raw_affiliation_strings":["Biology Department , Zaragoza University Sciences Faculty , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department , Zaragoza University Sciences Faculty , Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102173990","display_name":"Jes\u00fas Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Martin","raw_affiliation_strings":["Biology Department , Zaragoza University Sciences Faculty , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department , Zaragoza University Sciences Faculty , Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023213252","display_name":"Enrique Mostacero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Mostacero","raw_affiliation_strings":["Biology Department , Zaragoza University Sciences Faculty , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department , Zaragoza University Sciences Faculty , Spain","institution_ids":["https://openalex.org/I255234318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6381,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72071728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"5","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.6899999976158142},{"id":"https://openalex.org/keywords/aconitase","display_name":"aconitase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sporadic-als","display_name":"sporadic ALS","score":0.8059999942779541},{"id":"https://openalex.org/keywords/clinical-progression","display_name":"clinical progression","score":0.6480000019073486},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.8629999756813049},{"id":"https://openalex.org/keywords/alsfrs","display_name":"ALSFRS","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9397281408309937},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.8675574660301208},{"id":"https://openalex.org/C2776108821","wikidata":"https://www.wikidata.org/wiki/Q15335612","display_name":"SOD2","level":4,"score":0.7832719683647156},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6961729526519775},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6154617071151733},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.572652280330658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5667012929916382},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.554252028465271},{"id":"https://openalex.org/C200886947","wikidata":"https://www.wikidata.org/wiki/Q342083","display_name":"Aconitase","level":3,"score":0.5035421252250671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4645625650882721},{"id":"https://openalex.org/C2778248901","wikidata":"https://www.wikidata.org/wiki/Q5282371","display_name":"Dismutase","level":4,"score":0.4381875991821289},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.349117636680603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.333614319562912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2649925947189331},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16204679012298584},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10750851035118103}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1876532700901010005","doi":"https://doi.org/10.2174/1876532700901010005","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1876532700901010005","pdf_url":"http://benthamopen.com/contents/pdf/TOSPINEJ/TOSPINEJ-1-5.pdf","source":{"id":"https://openalex.org/S134405079","display_name":"The Open Spine Journal","issn_l":"1876-5327","issn":["1876-5327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Spine Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2174/1876532700901010005","doi":"https://doi.org/10.2174/1876532700901010005","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1876532700901010005","pdf_url":"http://benthamopen.com/contents/pdf/TOSPINEJ/TOSPINEJ-1-5.pdf","source":{"id":"https://openalex.org/S134405079","display_name":"The Open Spine Journal","issn_l":"1876-5327","issn":["1876-5327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Spine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981195281.pdf","grobid_xml":"https://content.openalex.org/works/W1981195281.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1487416252","https://openalex.org/W1497265707","https://openalex.org/W1554056672","https://openalex.org/W1964177214","https://openalex.org/W1970094644","https://openalex.org/W1977069725","https://openalex.org/W1982967923","https://openalex.org/W1993713215","https://openalex.org/W1996788873","https://openalex.org/W2011856025","https://openalex.org/W2023928434","https://openalex.org/W2036454611","https://openalex.org/W2056644558","https://openalex.org/W2065351534","https://openalex.org/W2086095107","https://openalex.org/W2087430568","https://openalex.org/W2088009451","https://openalex.org/W2090967079","https://openalex.org/W2090971266","https://openalex.org/W2115990474","https://openalex.org/W2117991410","https://openalex.org/W2128635872","https://openalex.org/W2137434543"],"related_works":["https://openalex.org/W2137434543","https://openalex.org/W2115990474","https://openalex.org/W1988540034","https://openalex.org/W2045426274","https://openalex.org/W4411845121","https://openalex.org/W2024384082","https://openalex.org/W2044088459","https://openalex.org/W2038697027","https://openalex.org/W2086095107","https://openalex.org/W2055364351"],"abstract_inverted_index":{"Background:":[0],"Evidence":[1],"suggests":[2],"that":[3,40],"mitochondrial":[4],"dysfunction":[5],"and":[6,59,64,68,82,89,109,129],"oxidative":[7],"stress":[8],"may":[9,136],"be":[10,137],"involved":[11,138],"in":[12,30,48,62,73,102,106,112,139],"the":[13,22,31,49,54,95,126,130,140],"pathogenesis":[14],"of":[15,24,33,75,116,143],"Amyotrophic":[16],"Lateral":[17],"Sclerosis":[18],"(ALS).Some":[19],"studies":[20],"show":[21],"presence":[23],"altered":[25],"anti-oxidative":[26],"defence":[27],"enzyme":[28,44],"activity":[29,58,70,99,135],"blood":[32],"ALS":[34,103,117],"patients.It":[35],"has":[36],"also":[37],"been":[38],"demonstrated":[39],"a":[41],"superoxide-dismutase-1":[42],"(SOD1)":[43],"fraction":[45],"is":[46],"located":[47],"mitochondria.":[50],"Objective:":[51],"To":[52],"Study":[53],"correlation":[55],"between":[56],"SOD1":[57,98,134],"clinical":[60,92,141],"data":[61,86,93],"ALS-patients.Patients":[63],"Methods:":[65],"SOD1,":[66],"SOD2":[67],"aconitase":[69],"was":[71,87,100],"analysed":[72],"mitochondria":[74],"platelets":[76],"from":[77,94],"nine":[78,83],"sporadic-ALS":[79],"(SALS)":[80],"patients":[81,104],"healthy-controls.The":[84],"biochemical":[85],"compared":[88],"correlated":[90],"with":[91,119],"ALS-patients.Results:":[96],"Mitochondrial":[97,133],"lower":[101,111],"than":[105],"healthy":[107],"controls,":[108],"much":[110],"more":[113],"serious":[114],"cases":[115],"associated":[118],"respiratory":[120],"insufficiency,":[121],"weight-loss,":[122],"low":[123],"scores":[124],"on":[125],"ALSFRS":[127],"scale":[128],"elderly.":[131],"Conclusion:":[132],"evolution":[142],"SALS.":[144]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
