{"id":"https://openalex.org/W1981152018","doi":"https://doi.org/10.1097/00006676-200008000-00013","title":"Menadione-Induced Oxidative Stress Inhibits Cholecystokinin-Stimulated Secretion of Pancreatic Acini by Cell Dehydration","display_name":"Menadione-Induced Oxidative Stress Inhibits Cholecystokinin-Stimulated Secretion of Pancreatic Acini by Cell Dehydration","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W1981152018","doi":"https://doi.org/10.1097/00006676-200008000-00013","mag":"1981152018","pmid":"https://pubmed.ncbi.nlm.nih.gov/10975714"},"language":"en","primary_location":{"id":"doi:10.1097/00006676-200008000-00013","doi":"https://doi.org/10.1097/00006676-200008000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006676-200008000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070360488","display_name":"Bing Han","orcid":"https://orcid.org/0000-0001-8303-5185","observed_orcids":["https://orcid.org/0000-0001-8303-5185"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bing Han","raw_affiliation_strings":["Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf Germany","Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082437668","display_name":"Hanne Klonowski-Stumpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanne Klonowski-Stumpe","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084013311","display_name":"Reinhard L then","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard L??then","raw_affiliation_strings":["Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037554008","display_name":"Rainer Schreiber","orcid":"https://orcid.org/0000-0002-3974-5363","observed_orcids":["https://orcid.org/0000-0002-3974-5363"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Schreiber","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111400754","display_name":"Dieter H\ufffdussinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dieter H??ussinger","raw_affiliation_strings":["Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112170733","display_name":"Claus Niederau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claus Niederau","raw_affiliation_strings":["Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Department of Medicine, Hepatology and Infectious Diseases, Heinrich-Heine-University of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112170733"],"corresponding_institution_ids":["https://openalex.org/I44260953"],"apc_list":null,"apc_paid":null,"fwci":0.2986,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.47692434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"21","issue":"2","first_page":"191","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pancreatic-acinar-cells","display_name":"pancreatic acinar cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/enzyme-secretion","display_name":"enzyme secretion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/amylase-release","display_name":"amylase release","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cellular-dehydration","display_name":"cell dehydration","score":0.9580000042915344},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6909999847412109},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.984000027179718},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8190000057220459},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.9819999933242798},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-damage","display_name":"cell damage","score":0.4959999918937683},{"id":"https://openalex.org/keywords/vacuolization","display_name":"vacuolization","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2781095387","wikidata":"https://www.wikidata.org/wiki/Q192471","display_name":"Menadione","level":3,"score":0.9103443622589111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5701137185096741},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5515326857566833},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4997823238372803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4518045485019684},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.4501670002937317},{"id":"https://openalex.org/C2780446580","wikidata":"https://www.wikidata.org/wiki/Q346854","display_name":"Acinus","level":3,"score":0.43480533361434937},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.42592281103134155},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4153153896331787},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4134730100631714},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4116540253162384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4055462181568146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3958072364330292},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.16013288497924805},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12533527612686157},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001834","descriptor_name":"Body Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011949","descriptor_name":"Receptors, Cholecystokinin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006676-200008000-00013","doi":"https://doi.org/10.1097/00006676-200008000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006676-200008000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},{"id":"pmid:10975714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1497717446","https://openalex.org/W1518880759","https://openalex.org/W1564829038","https://openalex.org/W1595656597","https://openalex.org/W1600119213","https://openalex.org/W1967048271","https://openalex.org/W1967994678","https://openalex.org/W1976935047","https://openalex.org/W1977741121","https://openalex.org/W1978688634","https://openalex.org/W1982748405","https://openalex.org/W2007064404","https://openalex.org/W2024716555","https://openalex.org/W2031107296","https://openalex.org/W2032438811","https://openalex.org/W2070194097","https://openalex.org/W2072544330","https://openalex.org/W2080164442","https://openalex.org/W2080350670","https://openalex.org/W2082178945","https://openalex.org/W2102213319","https://openalex.org/W2104109693","https://openalex.org/W2150751337","https://openalex.org/W2170553582","https://openalex.org/W2218262572","https://openalex.org/W2265179938","https://openalex.org/W2277762954","https://openalex.org/W2332697941","https://openalex.org/W2337401562","https://openalex.org/W2342744565","https://openalex.org/W2398533060","https://openalex.org/W2414596392"],"related_works":["https://openalex.org/W2009080781","https://openalex.org/W2161899812","https://openalex.org/W2030684569","https://openalex.org/W1967048271","https://openalex.org/W3046039466","https://openalex.org/W3141743406","https://openalex.org/W2093668839","https://openalex.org/W2926222670","https://openalex.org/W2147760107","https://openalex.org/W2031107296"],"abstract_inverted_index":{"The":[0,220],"present":[1],"study":[2],"evaluated":[3,31],"the":[4],"effects":[5],"of":[6,16,35,60,70,97,128,168,223,243],"free":[7,47],"radicals":[8,48],"generated":[9,46],"by":[10,54,83,112,132,136,159,172,207,237],"menadione":[11,137,180,229],"on":[12,21,150],"morphology":[13,32],"and":[14,26,33,50,68,74,94,115,117,135,147,152,196,210,215,251],"function":[15,34],"pancreatic":[17,38],"acinar":[18,39],"cells":[19,40],"focusing":[20],"enzyme":[22,225],"secretion,":[23],"stimulus-secretion":[24,244],"coupling,":[25],"cell":[27,57,120,129,238],"hydration.":[28],"Various":[29],"experiments":[30],"isolated":[36],"rat":[37],"exposed":[41],"to":[42,141,200,228,233],"menadione.":[43,160],"Menadione":[44,76,106,161],"instantaneously":[45],"(luminol":[49],"deoxyribose":[51],"assays)":[52],"followed":[53,82,171],"a":[55,78,84,95,123,142,173,185,234],"time-dependent":[56],"injury":[58],"(uptake":[59],"trypan":[61],"blue).":[62],"Early":[63],"ultrastructural":[64],"changes":[65,216],"included":[66],"vacuolization":[67],"alterations":[69,198],"mitochondria,":[71],"endoplasmic":[72],"reticulum,":[73],"nucleus.":[75],"caused":[77,119,206],"rapid":[79],"glutathione":[80,211],"oxidation":[81],"depletion":[85,96],"in":[86,91,217],"reduced":[87],"glutathione.":[88],"An":[89],"increase":[90,167],"lipid":[92,213],"peroxides":[93],"adenosine":[98,208],"triphosphate":[99,209],"were":[100,156],"seen":[101,190],"only":[102],"after":[103,122,191],"30-60":[104],"minutes.":[105,125],"markedly":[107],"inhibited":[108,138],"amylase":[109,139],"release":[110],"stimulated":[111],"cholecystokinin":[113],"(CCK)":[114],"carbachol":[116],"simultaneously":[118],"shrinkage":[121,130],"few":[124],"Similar":[126],"degrees":[127],"induced":[131,164,181],"hyperosmolar":[133],"incubation":[134],"secretion":[140,226],"similar":[143],"extent.":[144],"CCK":[145,192],"binding":[146],"its":[148],"effect":[149],"calcium":[151,170,182,249],"inositol":[153],"1,4,5-trisphosphate":[154],"(IP3)":[155],"not":[157],"affected":[158],"(without":[162],"CCK)":[163],"an":[165],"instantaneous":[166],"intracellular":[169],"slow":[174],"constant":[175],"increase.":[176],"In":[177],"single":[178],"cells,":[179],"oscillations":[183],"with":[184],"frequency":[186],"lower":[187],"than":[188],"that":[189],"stimulation.":[193],"Some":[194],"morphologic":[195],"functional":[197],"owing":[199,227],"menadione-induced":[201],"oxidative":[202],"stress":[203],"may":[204,230],"be":[205,231],"depletion,":[212],"peroxidation,":[214],"cytosolic":[218],"calcium.":[219],"marked":[221],"inhibition":[222],"secretagogue-stimulated":[224],"mediated":[232],"large":[235],"part":[236],"dehydration,":[239],"whereas":[240],"classical":[241],"steps":[242],"coupling":[245],"like":[246],"receptor":[247],"binding,":[248],"release,":[250],"IP3":[252],"generation":[253],"remained":[254],"unchanged.":[255]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}