{"id":"https://openalex.org/W1981128745","doi":"https://doi.org/10.1016/s0361-9230(00)00370-1","title":"Molecular mechanism of neurodegeneration induced by Alzheimer\u2019s \u03b2-amyloid protein: channel formation and disruption of calcium homeostasis","display_name":"Molecular mechanism of neurodegeneration induced by Alzheimer\u2019s \u03b2-amyloid protein: channel formation and disruption of calcium homeostasis","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W1981128745","doi":"https://doi.org/10.1016/s0361-9230(00)00370-1","mag":"1981128745","pmid":"https://pubmed.ncbi.nlm.nih.gov/11136994"},"language":"en","primary_location":{"id":"doi:10.1016/s0361-9230(00)00370-1","doi":"https://doi.org/10.1016/s0361-9230(00)00370-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0361-9230(00)00370-1","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1981128745"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057317715","display_name":"Masahiro Kawahara","orcid":"https://orcid.org/0000-0002-3334-4235","observed_orcids":["https://orcid.org/0000-0002-3334-4235"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Masahiro Kawahara","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. kawamasa@tmin.ac.jp","Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. kawamasa@tmin.ac.jp","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041313789","display_name":"Yoichiro Kuroda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoichiro Kuroda","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057317715"],"corresponding_institution_ids":[],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":null,"fwci":0.908,"has_fulltext":false,"cited_by_count":227,"citation_normalized_percentile":{"value":0.65602322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"53","issue":"4","first_page":"389","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/beta-amyloid-protein","display_name":"beta-amyloid protein","score":0.8870000243186951},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9739999771118164},{"id":"https://openalex.org/keywords/calcium-permeable-channels","display_name":"calcium-permeable channels","score":0.7440000176429749},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pore-formation","display_name":"pore formation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/gt1-7-cells","display_name":"GT1-7 cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hypothalamic-neurons","display_name":"hypothalamic neurons","score":0.7929999828338623},{"id":"https://openalex.org/keywords/membrane-lipid-composition","display_name":"membrane lipid composition","score":0.6380000114440918},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/conformational-diseases","display_name":"conformational diseases","score":0.9240000247955322},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8895331621170044},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6107382774353027},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5220199227333069},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5065277814865112},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5051105618476868},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4767340421676636},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.47583770751953125},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.47479528188705444},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.47463640570640564},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.463024765253067},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4604175388813019},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.4477699100971222},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.4441232681274414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4372175335884094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37303099036216736},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37060102820396423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19691213965415955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18228518962860107},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.06372925639152527},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0361-9230(00)00370-1","doi":"https://doi.org/10.1016/s0361-9230(00)00370-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0361-9230(00)00370-1","pdf_url":null,"source":{"id":"https://openalex.org/S8119441","display_name":"Brain Research Bulletin","issn_l":"0361-9230","issn":["0361-9230","1873-2747"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research Bulletin","raw_type":"journal-article"},{"id":"pmid:11136994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11136994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research bulletin","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323458","display_name":"Universidad de Chile","ror":"https://ror.org/047gc3g35"},{"id":"https://openalex.org/F4320332504","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W135479848","https://openalex.org/W1568953429","https://openalex.org/W1963849673","https://openalex.org/W1968970931","https://openalex.org/W1972409470","https://openalex.org/W1973504417","https://openalex.org/W1979364057","https://openalex.org/W1980248994","https://openalex.org/W1981545549","https://openalex.org/W1989269014","https://openalex.org/W1990059223","https://openalex.org/W1990730589","https://openalex.org/W1991355594","https://openalex.org/W1992231742","https://openalex.org/W1994038171","https://openalex.org/W2000769077","https://openalex.org/W2001751866","https://openalex.org/W2001870435","https://openalex.org/W2007298400","https://openalex.org/W2008790098","https://openalex.org/W2018582658","https://openalex.org/W2021957834","https://openalex.org/W2029422688","https://openalex.org/W2030749159","https://openalex.org/W2031102482","https://openalex.org/W2032284161","https://openalex.org/W2036288989","https://openalex.org/W2036362108","https://openalex.org/W2044128504","https://openalex.org/W2048172946","https://openalex.org/W2049504098","https://openalex.org/W2049887536","https://openalex.org/W2051221402","https://openalex.org/W2056046302","https://openalex.org/W2058368188","https://openalex.org/W2058713053","https://openalex.org/W2059214757","https://openalex.org/W2060085692","https://openalex.org/W2061531041","https://openalex.org/W2061733977","https://openalex.org/W2062990728","https://openalex.org/W2063807916","https://openalex.org/W2067746291","https://openalex.org/W2072630649","https://openalex.org/W2073686561","https://openalex.org/W2075453627","https://openalex.org/W2075677730","https://openalex.org/W2076673675","https://openalex.org/W2077651746","https://openalex.org/W2077662803","https://openalex.org/W2081678091","https://openalex.org/W2081998222","https://openalex.org/W2082038580","https://openalex.org/W2087861584","https://openalex.org/W2089843826","https://openalex.org/W2098576607","https://openalex.org/W2101119637","https://openalex.org/W2103440561","https://openalex.org/W2122432519","https://openalex.org/W2152958744","https://openalex.org/W2403402357","https://openalex.org/W2525060237","https://openalex.org/W4240929891","https://openalex.org/W4248063930","https://openalex.org/W6713890108"],"related_works":["https://openalex.org/W2034034505","https://openalex.org/W2105094332","https://openalex.org/W1976280318","https://openalex.org/W3022856061","https://openalex.org/W2010199350","https://openalex.org/W2098576607","https://openalex.org/W2075930760","https://openalex.org/W479792356","https://openalex.org/W2416558377"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}