{"id":"https://openalex.org/W1981122638","doi":"https://doi.org/10.1002/lt.22214","title":"Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury","display_name":"Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury","publication_year":2010,"publication_date":"2010-10-27","ids":{"openalex":"https://openalex.org/W1981122638","doi":"https://doi.org/10.1002/lt.22214","mag":"1981122638","pmid":"https://pubmed.ncbi.nlm.nih.gov/21280193","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058297"},"language":"en","primary_location":{"id":"doi:10.1002/lt.22214","doi":"https://doi.org/10.1002/lt.22214","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.22214","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058297","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111554008","display_name":"Xiu\u2010Da Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiu-Da Shen","raw_affiliation_strings":["Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Dumont-UCLA Transplant Center, Los Angeles, CA 90095, USA","Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Dumont-UCLA Transplant Center, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045209569","display_name":"Bibo Ke","orcid":"https://orcid.org/0000-0002-1885-1538","observed_orcids":["https://orcid.org/0000-0002-1885-1538"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibo Ke","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057053381","display_name":"Yoichiro Uchida","orcid":"https://orcid.org/0000-0003-2266-7722","observed_orcids":["https://orcid.org/0000-0003-2266-7722"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoichiro Uchida","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474194","display_name":"Haofeng Ji","orcid":"https://orcid.org/0000-0002-7707-9090","observed_orcids":["https://orcid.org/0000-0002-7707-9090"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haofeng Ji","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037211841","display_name":"Yuan Zhai","orcid":"https://orcid.org/0000-0003-0485-4022","observed_orcids":["https://orcid.org/0000-0003-0485-4022"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Zhai","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075909338","display_name":"Ronald W. Busuttil","orcid":"https://orcid.org/0000-0001-8157-1531","observed_orcids":["https://orcid.org/0000-0001-8157-1531"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald W. Busuttil","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016218484","display_name":"Jerzy W. Kupiec\u2010Weglinski","orcid":"https://orcid.org/0000-0001-8976-4872","observed_orcids":["https://orcid.org/0000-0001-8976-4872"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerzy W. Kupiec-Weglinski","raw_affiliation_strings":["Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","Telephone: 310-825-4196; FAX: 310-267-2358","FAX: 310-267-2358","Telephone: 310-825-4196"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Telephone: 310-825-4196; FAX: 310-267-2358","institution_ids":[]},{"raw_affiliation_string":"FAX: 310-267-2358","institution_ids":[]},{"raw_affiliation_string":"Telephone: 310-825-4196","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016218484"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":2.3591,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.87283808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"17","issue":"2","first_page":"201","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.11909999698400497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9940000176429749},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.781000018119812},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7049999833106995},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.5130000114440918},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8629999756813049},{"id":"https://openalex.org/keywords/leukocyte-sequestration","display_name":"leukocyte sequestration","score":0.722000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8069999814033508},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8989999890327454},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.39100000262260437},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8215575218200684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5908190608024597},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5649769306182861},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5478555560112},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5040653944015503},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4984164237976074},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48054248094558716},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.47546499967575073},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4594138562679291},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.43508002161979675},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4193817973136902},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37962496280670166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.366877019405365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36188697814941406},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.3349851369857788},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23547318577766418},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2344081997871399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2197819948196411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2020229995250702},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.17284205555915833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15923309326171875},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09941539168357849},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014185","descriptor_name":"Transplantation, Isogeneic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050377","descriptor_name":"Cold Ischemia","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/lt.22214","doi":"https://doi.org/10.1002/lt.22214","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lt.22214","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:21280193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21280193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3058297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058297","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Liver Transpl","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3058297","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3058297","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Liver Transpl","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2091283467","display_name":"CD4+ T REG CELLS IN MAINTENANCE OF TRANSPLANT TOLERANCE","funder_award_id":"R01AI042223","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4998903197","display_name":"COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS","funder_award_id":"R01AI023847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5645731719","display_name":"COSTIMULATORY PATHWAYS IN SENSITIZED GRAFT RECIPIENTS","funder_award_id":"R56AI023847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6075649901","display_name":null,"funder_award_id":"AI23847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G770363607","display_name":"COSTIMULATORY PATHWAYS SENSITIZED GRAFT RECIPIENTS","funder_award_id":"R21AI023847","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G869156900","display_name":null,"funder_award_id":"AI42223","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898292","display_name":"HuR/HIF \u2013 SIRT1 Signaling Axis in Liver Transplant Rejuvenation","funder_award_id":"R01DK062357","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W120883508","https://openalex.org/W162447880","https://openalex.org/W197615574","https://openalex.org/W1489742081","https://openalex.org/W1568253208","https://openalex.org/W1585585503","https://openalex.org/W1677024991","https://openalex.org/W1977445279","https://openalex.org/W1991303210","https://openalex.org/W1992470444","https://openalex.org/W2008499605","https://openalex.org/W2011305280","https://openalex.org/W2013626478","https://openalex.org/W2018229946","https://openalex.org/W2020941408","https://openalex.org/W2028502712","https://openalex.org/W2032225648","https://openalex.org/W2050971607","https://openalex.org/W2058706346","https://openalex.org/W2059829735","https://openalex.org/W2065284764","https://openalex.org/W2068326328","https://openalex.org/W2069162788","https://openalex.org/W2089573702","https://openalex.org/W2105754873","https://openalex.org/W2108131089","https://openalex.org/W2113552021","https://openalex.org/W2123011696","https://openalex.org/W2130866079","https://openalex.org/W2135921495","https://openalex.org/W2145530136","https://openalex.org/W2153251153","https://openalex.org/W2165192883","https://openalex.org/W2167097725"],"related_works":["https://openalex.org/W2008499605","https://openalex.org/W2048974242","https://openalex.org/W3007776476","https://openalex.org/W2050971607","https://openalex.org/W3031527055","https://openalex.org/W974392358","https://openalex.org/W2072353087","https://openalex.org/W2039058199","https://openalex.org/W2772449648","https://openalex.org/W2770595858"],"abstract_inverted_index":{"We":[0],"investigated":[1],"whether":[2],"native":[3,214,236],"macrophages":[4,48,120,215,237],"overexpressing":[5],"heme":[6,56],"oxygenase":[7,57],"1":[8,58,163],"(HO-1)":[9],"could":[10],"protect":[11],"rat":[12,223],"orthotopic":[13],"liver":[14,258,303],"transplant":[15],"(OLT)":[16],"against":[17],"cold":[18],"ischemia/reperfusion":[19],"injury":[20,261],"(IRI).":[21],"Livers":[22],"from":[23,225,263],"Sprague-Dawley":[24],"rats":[25],"were":[26,41,51,70,79],"stored":[27],"at":[28,248],"4\u00b0C":[29],"in":[30,207,278,285],"University":[31],"of":[32,90,95,112,119,139,176,194,213,251,292,302],"Wisconsin":[33],"solution":[34],"for":[35,101,180],"24":[36],"hours,":[37],"and":[38,103,109,150,156,188,196,232,260,296],"then":[39],"they":[40],"transplanted":[42],"into":[43,73],"syngeneic":[44],"recipients.":[45],"Bone":[46],"marrow-derived":[47],"(BMMs)":[49],"that":[50],"transfected":[52,121,216,238],"ex":[53,217,239],"vivo":[54,218,240],"with":[55,82,122,165,219,241],"adenovirus":[59,62],"(Ad-HO-1),":[60],"\u03b2-galactosidase":[61],"(Ad-\u03b2-gal),":[63],"or":[64,84],"HO-1":[65,123,131,220,244],"small":[66],"interfering":[67],"RNA":[68],"(siRNA)":[69],"infused":[71],"directly":[72],"the":[74,93,174,192,211,242,249,264,290,299],"OLT":[75,80,96,168],"before":[76],"reperfusion.":[77],"Controls":[78],"conditioned":[81],"unmodified":[83],"scrambled":[85],"siRNA-transfected":[86],"cells.":[87],"The":[88],"transfer":[89,212],"Ad-HO-1/BMMs":[91,172],"increased":[92,206],"survival":[94],"to":[97,126,253,275,288],"100%":[98],"(versus":[99],"40%-50%":[100],"controls)":[102],"decreased":[104,137,173],"serum":[105],"alanine":[106],"aminotransferase":[107],"levels":[108],"histological":[110],"features":[111],"hepatocellular":[113],"damage.":[114],"In":[115],"contrast,":[116],"an":[117],"infusion":[118],"siRNA/Ad-\u03b2-gal":[124],"failed":[125],"affect":[127],"IRI.":[128,226],"Gene":[129],"therapy-induced":[130],"suppressed":[132],"toll-like":[133],"receptor":[134],"4":[135],"expression,":[136],"expression":[138,164,193],"proinflammatory":[140],"tumor":[141],"necrosis":[142],"factor":[143],"\u03b1,":[144],"interleukin-1\u03b2,":[145],"monocyte":[146],"chemoattractant":[147],"protein":[148],"1,":[149],"chemokine":[151],"(C-X-C":[152],"motif)":[153],"ligand":[154],"10,":[155],"attenuated":[157],"endothelial":[158],"intercellular":[159],"cell":[160,199,202],"adhesion":[161],"molecule":[162],"resultant":[166],"diminished":[167],"leukocyte":[169],"sequestration.":[170],"Although":[171],"frequency":[175],"apoptotic":[177],"cells":[178],"positive":[179],"terminal":[181],"deoxynucleotidyl":[182],"transferase-mediated":[183],"deoxyuridine":[184],"triphosphate":[185],"nick-end":[186],"labeling":[187],"ameliorated":[189],"caspase-3":[190],"activity,":[191],"interleukin-10":[195],"antiapoptotic":[197],"B":[198],"lymphoma":[200,203],"2/B":[201],"extra":[204],"large":[205],"well-functioning":[208],"OLT.":[209],"Thus,":[210],"can":[221,245],"rescue":[222],"iso-OLT":[224],"Our":[227],"study":[228],"validates":[229],"a":[230],"novel":[231],"clinically":[233],"attractive":[234],"concept:":[235],"antioxidant":[243],"be":[246,276,283],"applied":[247],"time":[250],"transplantation":[252],"mitigate":[254],"otherwise":[255],"damaging":[256],"antigen-independent":[257],"inflammation":[259],"resulting":[262],"peritransplant":[265],"harvesting":[266],"insult.":[267],"If":[268],"this":[269],"new,":[270],"refined":[271],"strategy":[272],"is":[273],"proven":[274],"effective":[277],"allo-OLT":[279],"recipients,":[280],"it":[281],"should":[282],"considered":[284],"clinical":[286],"settings":[287],"increase":[289],"supply":[291],"usable":[293],"donor":[294],"organs":[295],"ultimately":[297],"improve":[298],"overall":[300],"success":[301],"transplantation.":[304]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}