{"id":"https://openalex.org/W1981064064","doi":"https://doi.org/10.1093/nar/21.23.5509","title":"Selective optimization of the Rev-binding element of HIV-1","display_name":"Selective optimization of the Rev-binding element of HIV-1","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1981064064","doi":"https://doi.org/10.1093/nar/21.23.5509","mag":"1981064064","pmid":"https://pubmed.ncbi.nlm.nih.gov/7505429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/310594"},"language":"en","primary_location":{"id":"doi:10.1093/nar/21.23.5509","doi":"https://doi.org/10.1093/nar/21.23.5509","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/21.23.5509","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC310594","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005102131","display_name":"Lori Giver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Giver","raw_affiliation_strings":["Department of Chemistry, Indiana University, Bloomington 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indiana University, Bloomington 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087589263","display_name":"David P. Bartel","orcid":"https://orcid.org/0000-0002-3872-2856","observed_orcids":["https://orcid.org/0000-0002-3872-2856"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Bartel","raw_affiliation_strings":["Department of Molecular Biology, Massachusetts General Hospital Boston, MA 02118","Harvard University","Indiana University Bloomington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital Boston, MA 02118","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Indiana University Bloomington","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067483520","display_name":"Maria L. Zapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Zapp","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical Center Worcester, MA 01605, USA","Indiana University Bloomington","University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical Center Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Indiana University Bloomington","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032334068","display_name":"Anna Pawul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Pawul","raw_affiliation_strings":["Indiana University. Bloomington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University. Bloomington","institution_ids":["https://openalex.org/I4210119109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060605798","display_name":"Michael R. Green","orcid":"https://orcid.org/0000-0003-3017-3298","observed_orcids":["https://orcid.org/0000-0003-3017-3298","https://orcid.org/0000-0001-6309-9472"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Green","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical Center Worcester, MA 01605, USA","Indiana University Bloomington","University of Massachusetts Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical Center Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Indiana University Bloomington","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"University of Massachusetts Medical School","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089627980","display_name":"Andrew D. Ellington","orcid":"https://orcid.org/0000-0001-6246-5338","observed_orcids":["https://orcid.org/0000-0001-6246-5338"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrew D. Ellington","raw_affiliation_strings":["Molecular Biosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biosciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5089627980"],"corresponding_institution_ids":[],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":3.8606,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.94745676,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"23","first_page":"5509","last_page":"5516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.11209999769926071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-rev","display_name":"HIV-1 Rev protein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rev-response-element","display_name":"Rev response element","score":0.7409999966621399},{"id":"https://openalex.org/keywords/rna-aptamers","display_name":"RNA aptamers","score":0.9359999895095825},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.6140000224113464},{"id":"https://openalex.org/keywords/rna-structure","display_name":"RNA structure","score":0.3889999985694885},{"id":"https://openalex.org/keywords/syn-conformation","display_name":"syn conformation","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8041621446609497},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.7025627493858337},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.698466420173645},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6006097793579102},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5509636402130127},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5108558535575867},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.4327894449234009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42168042063713074},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4197794198989868},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.41501277685165405},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3737519383430481},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.34201914072036743},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21868598461151123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16539964079856873}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015694","descriptor_name":"Gene Products, rev","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054321","descriptor_name":"rev Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/21.23.5509","doi":"https://doi.org/10.1093/nar/21.23.5509","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/21.23.5509","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:239402","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC310594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:310594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/310594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:7505429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7505429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.912.8222","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.912.8222","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/21/23/5509.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:239402","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC310594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W257454419","https://openalex.org/W1481553830","https://openalex.org/W1490558618","https://openalex.org/W1601687245","https://openalex.org/W1659684293","https://openalex.org/W1675934496","https://openalex.org/W1964916693","https://openalex.org/W1966364598","https://openalex.org/W1972183334","https://openalex.org/W1975919410","https://openalex.org/W1981578463","https://openalex.org/W1985861003","https://openalex.org/W2015625581","https://openalex.org/W2019143192","https://openalex.org/W2023250124","https://openalex.org/W2027371180","https://openalex.org/W2029467097","https://openalex.org/W2029503078","https://openalex.org/W2031985285","https://openalex.org/W2036228528","https://openalex.org/W2036358440","https://openalex.org/W2040421291","https://openalex.org/W2041621022","https://openalex.org/W2051507077","https://openalex.org/W2067072259","https://openalex.org/W2071643046","https://openalex.org/W2079321730","https://openalex.org/W2084208256","https://openalex.org/W2094650831","https://openalex.org/W2104525153","https://openalex.org/W2123425704","https://openalex.org/W2140595736","https://openalex.org/W2404483442","https://openalex.org/W2461163283"],"related_works":["https://openalex.org/W1971409149","https://openalex.org/W2040790546","https://openalex.org/W1757867847","https://openalex.org/W2001264233","https://openalex.org/W2037329697","https://openalex.org/W2884153947","https://openalex.org/W2071643046","https://openalex.org/W1967358195","https://openalex.org/W2091653936","https://openalex.org/W1994426972"],"abstract_inverted_index":{"RNA":[0],"molecules":[1],"that":[2,48,77],"can":[3],"bind":[4,52],"to":[5,40,51,55,141],"the":[6,29,35,41,71,88,92,104,110,125,157,161],"Rev":[7,30,53,105],"protein":[8,106],"of":[9,74,119,131,148],"HIV-1":[10],"have":[11],"been":[12],"isolated":[13],"from":[14,124],"random":[15],"sequence":[16,111],"nucleic":[17],"acid":[18],"pools":[19],"based":[20],"on":[21],"a":[22,82],"minimal":[23],"Rev-binding":[24,144],"element":[25],"(RBE)":[26],"found":[27,115],"within":[28],"Responsive":[31],"Element":[32],"(RRE).":[33],"While":[34],"selected":[36,162],"sequences":[37],"are":[38,107],"related":[39],"wild-type":[42,126,158],"element,":[43],"they":[44],"also":[45],"contain":[46],"substitutions":[47,151],"allow":[49],"them":[50],"up":[54],"10-fold":[56],"better":[57],"in":[58,81,116],"vitro.":[59],"A":[60],"hypothesized":[61],"homopurine":[62],"pairing":[63],"at":[64],"G48:G71":[65],"is":[66],"generally":[67],"replaced":[68],"by":[69,96,109],"A48:A71;":[70],"occasional":[72],"selection":[73],"C48:A71":[75],"suggests":[76],"R71":[78],"may":[79],"be":[80],"syn":[83],"conformation.":[84],"These":[85],"data":[86],"support":[87],"structural":[89,153],"model":[90],"for":[91,155],"RBE":[93,159],"originally":[94],"proposed":[95],"Bartel":[97],"et":[98],"al.":[99],"(1).":[100],"Additional":[101],"interactions":[102],"with":[103,138],"promoted":[108],"CUC":[112],"...":[113],"UYGAG,":[114],"one":[117,139],"class":[118,130],"high-affinity":[120,163],"aptamers,":[121],"but":[122],"absent":[123],"element.":[127],"Within":[128],"each":[129],"aptamers":[132],"different":[133,149],"residues":[134],"and":[135,160],"substructures":[136],"covary":[137],"another":[140],"generate":[142],"optimal":[143],"surfaces.":[145],"The":[146],"interdependencies":[147],"nucleotide":[150],"suggest":[152],"models":[154],"both":[156],"aptamers.":[164]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}