{"id":"https://openalex.org/W1981017801","doi":"https://doi.org/10.1016/j.archoralbio.2012.04.016","title":"Autoinducer 2 of Fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens","display_name":"Autoinducer 2 of Fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens","publication_year":2012,"publication_date":"2012-05-26","ids":{"openalex":"https://openalex.org/W1981017801","doi":"https://doi.org/10.1016/j.archoralbio.2012.04.016","mag":"1981017801","pmid":"https://pubmed.ncbi.nlm.nih.gov/22633049"},"language":"en","primary_location":{"id":"doi:10.1016/j.archoralbio.2012.04.016","doi":"https://doi.org/10.1016/j.archoralbio.2012.04.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.archoralbio.2012.04.016","pdf_url":null,"source":{"id":"https://openalex.org/S44717366","display_name":"Archives of Oral Biology","issn_l":"0003-9969","issn":["0003-9969","1879-1506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Oral Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100832677","display_name":"Yun\u2010Ji Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun-Ji Jang","raw_affiliation_strings":["Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074164770","display_name":"Yu-Jung Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu-Jung Choi","raw_affiliation_strings":["Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741444","display_name":"Sung\u2010Hoon Lee","orcid":"https://orcid.org/0000-0002-8852-0419","observed_orcids":["https://orcid.org/0000-0002-8852-0419"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Hoon Lee","raw_affiliation_strings":["Department of Oral Microbiology and Immunology, College of Dentistry, Dankook University, Cheonan, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology and Immunology, College of Dentistry, Dankook University, Cheonan, Republic of Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073060218","display_name":"Hye\u2010Kyoung Jun","orcid":"https://orcid.org/0009-0007-4888-4086","observed_orcids":["https://orcid.org/0009-0007-4888-4086","https://orcid.org/0000-0002-6225-8678"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Kyoung Jun","raw_affiliation_strings":["Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061275785","display_name":"Bong\u2010Kyu Choi","orcid":"https://orcid.org/0000-0003-3743-7209","observed_orcids":["https://orcid.org/0000-0003-3743-7209"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Bong-Kyu Choi","raw_affiliation_strings":["Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea","Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061275785"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":null,"fwci":1.8898,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.85557282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"58","issue":"1","first_page":"17","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.24410000443458557,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoinducer-2","display_name":"autoinducer-2","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fusobacterium-nucleatum","display_name":"Fusobacterium nucleatum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.9049999713897705},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.7879999876022339},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.9359999895095825},{"id":"https://openalex.org/keywords/red-complex","display_name":"red complex","score":0.8610000014305115},{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/treponema-denticola","display_name":"Treponema denticola","score":1.0},{"id":"https://openalex.org/keywords/tannerella-forsythia","display_name":"Tannerella forsythia","score":1.0},{"id":"https://openalex.org/keywords/coaggregation","display_name":"co-aggregation","score":0.871999979019165},{"id":"https://openalex.org/keywords/qs-inhibitors","display_name":"QS inhibitors","score":0.6990000009536743},{"id":"https://openalex.org/keywords/d-ribose","display_name":"D-ribose","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interspecies-interactions","display_name":"interspecies interactions","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777349128","wikidata":"https://www.wikidata.org/wiki/Q5510311","display_name":"Fusobacterium nucleatum","level":4,"score":0.9886343479156494},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9255270957946777},{"id":"https://openalex.org/C2777422794","wikidata":"https://www.wikidata.org/wiki/Q2534751","display_name":"Treponema denticola","level":4,"score":0.854276180267334},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7916010618209839},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.7291082143783569},{"id":"https://openalex.org/C2776202939","wikidata":"https://www.wikidata.org/wiki/Q1137677","display_name":"Fusobacteria","level":5,"score":0.4983205795288086},{"id":"https://openalex.org/C2779914569","wikidata":"https://www.wikidata.org/wiki/Q143504","display_name":"Dental plaque","level":2,"score":0.47208258509635925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4416676163673401},{"id":"https://openalex.org/C2777327803","wikidata":"https://www.wikidata.org/wiki/Q7683667","display_name":"Tannerella forsythia","level":5,"score":0.4377969801425934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4374021887779236},{"id":"https://openalex.org/C2776357993","wikidata":"https://www.wikidata.org/wiki/Q4840030","display_name":"Bacteroidaceae","level":3,"score":0.4232257008552551},{"id":"https://openalex.org/C2780960513","wikidata":"https://www.wikidata.org/wiki/Q2720082","display_name":"Fusobacterium","level":4,"score":0.42239388823509216},{"id":"https://openalex.org/C2780014169","wikidata":"https://www.wikidata.org/wiki/Q7168662","display_name":"Periodontal pathogen","level":4,"score":0.41834622621536255},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41482269763946533},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.23110729455947876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13882189989089966},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779005926","wikidata":"https://www.wikidata.org/wiki/Q156047","display_name":"Honeysuckle","level":4,"score":0.0},{"id":"https://openalex.org/C2777385719","wikidata":"https://www.wikidata.org/wiki/Q1061265","display_name":"Bacteroidetes","level":4,"score":0.0},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001431","descriptor_name":"Bacteriological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001439","descriptor_name":"Bacteroides","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005840","descriptor_name":"Gentian Violet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006714","descriptor_name":"Homoserine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006714","descriptor_name":"Homoserine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012266","descriptor_name":"Ribose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012266","descriptor_name":"Ribose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016966","descriptor_name":"Porphyromonas gingivalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016967","descriptor_name":"Fusobacterium nucleatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018533","descriptor_name":"Biomass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D048373","descriptor_name":"Treponema denticola","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049449","descriptor_name":"Luminescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050296","descriptor_name":"Microbial Viability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.archoralbio.2012.04.016","doi":"https://doi.org/10.1016/j.archoralbio.2012.04.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.archoralbio.2012.04.016","pdf_url":null,"source":{"id":"https://openalex.org/S44717366","display_name":"Archives of Oral Biology","issn_l":"0003-9969","issn":["0003-9969","1879-1506"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Oral Biology","raw_type":"journal-article"},{"id":"pmid:22633049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22633049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of oral biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1494718950","https://openalex.org/W1940549522","https://openalex.org/W1943112463","https://openalex.org/W1974927036","https://openalex.org/W1992007782","https://openalex.org/W1993616876","https://openalex.org/W2001701624","https://openalex.org/W2004625925","https://openalex.org/W2021161135","https://openalex.org/W2025248886","https://openalex.org/W2036922717","https://openalex.org/W2039582130","https://openalex.org/W2040641257","https://openalex.org/W2044380556","https://openalex.org/W2058454385","https://openalex.org/W2061520106","https://openalex.org/W2069228394","https://openalex.org/W2071054356","https://openalex.org/W2071784720","https://openalex.org/W2099185954","https://openalex.org/W2107277218","https://openalex.org/W2108264246","https://openalex.org/W2109864955","https://openalex.org/W2121992777","https://openalex.org/W2125268958","https://openalex.org/W2131573792","https://openalex.org/W2142596421","https://openalex.org/W2142726625","https://openalex.org/W2144014672","https://openalex.org/W2144640625","https://openalex.org/W2146292204","https://openalex.org/W2150890529","https://openalex.org/W2151001863","https://openalex.org/W2152710136","https://openalex.org/W2154819662","https://openalex.org/W2156628221","https://openalex.org/W2157107389","https://openalex.org/W2162149255","https://openalex.org/W2168557435","https://openalex.org/W2951068392","https://openalex.org/W4254280253"],"related_works":["https://openalex.org/W2076093958","https://openalex.org/W2515920012","https://openalex.org/W2616419025","https://openalex.org/W4392192457","https://openalex.org/W2753956022","https://openalex.org/W2044380556","https://openalex.org/W7169753340","https://openalex.org/W1912152183","https://openalex.org/W2131573792","https://openalex.org/W2086644363"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}