{"id":"https://openalex.org/W1980972742","doi":"https://doi.org/10.1182/blood-2011-10-387787","title":"Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera","display_name":"Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera","publication_year":2011,"publication_date":"2011-12-13","ids":{"openalex":"https://openalex.org/W1980972742","doi":"https://doi.org/10.1182/blood-2011-10-387787","mag":"1980972742","pmid":"https://pubmed.ncbi.nlm.nih.gov/22160617"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2011-10-387787","doi":"https://doi.org/10.1182/blood-2011-10-387787","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2011-10-387787","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000389588","display_name":"Alberto \u00c1lvarez\u2010Larr\u00e1n","orcid":"https://orcid.org/0000-0001-6387-4619","observed_orcids":["https://orcid.org/0000-0001-6387-4619"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Alvarez-Larr\u00e1n","raw_affiliation_strings":["Department of Hematology, Hospital del Mar, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital del Mar, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000087123","display_name":"Arturo Pereira","orcid":"https://orcid.org/0000-0003-2711-422X","observed_orcids":["https://orcid.org/0000-0003-2711-422X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arturo Pereira","raw_affiliation_strings":["Department of Hemotherapy and Hemostasis, Hospital Cl\u00ednic, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemotherapy and Hemostasis, Hospital Cl\u00ednic, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018111458","display_name":"Francisco Cervantes","orcid":"https://orcid.org/0000-0003-2664-8131","observed_orcids":["https://orcid.org/0000-0003-2664-8131"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Cervantes","raw_affiliation_strings":["Department of Hematology, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021406141","display_name":"Eduardo Arellano\u2010Rodrigo","orcid":"https://orcid.org/0000-0001-6236-7826","observed_orcids":["https://orcid.org/0000-0001-6236-7826"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Arellano-Rodrigo","raw_affiliation_strings":["Department of Hemotherapy and Hemostasis, Hospital Cl\u00ednic, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hemotherapy and Hemostasis, Hospital Cl\u00ednic, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070420697","display_name":"Juan Carlos Hern\u00e1ndez\u2010Boluda","orcid":"https://orcid.org/0000-0002-4289-3113","observed_orcids":["https://orcid.org/0000-0002-4289-3113"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan-Carlos Hern\u00e1ndez-Boluda","raw_affiliation_strings":["Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003329910","display_name":"Francisca Ferrer\u2010Mar\u00edn","orcid":"https://orcid.org/0000-0002-9520-3243","observed_orcids":["https://orcid.org/0000-0002-9520-3243"]},"institutions":[{"id":"https://openalex.org/I4210091031","display_name":"Hospital General Universitario Morales Meseguer","ror":"https://ror.org/00cfm3y81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210091031"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisca Ferrer-Mar\u00edn","raw_affiliation_strings":["Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;","institution_ids":["https://openalex.org/I4210091031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038339678","display_name":"Anna Angona","orcid":"https://orcid.org/0000-0002-0965-9501","observed_orcids":["https://orcid.org/0000-0002-0965-9501"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Angona","raw_affiliation_strings":["Department of Hematology, Hospital del Mar, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital del Mar, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111579452","display_name":"Montse G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montse G\u00f3mez","raw_affiliation_strings":["Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061947849","display_name":"Bego\u00f1a Mui\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091031","display_name":"Hospital General Universitario Morales Meseguer","ror":"https://ror.org/00cfm3y81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210091031"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bego\u00f1a Mui\u00f1a","raw_affiliation_strings":["Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;","institution_ids":["https://openalex.org/I4210091031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037323597","display_name":"Helga Guill\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106572","display_name":"Hospital Universitario Pr\u00edncipe de Asturias","ror":"https://ror.org/01az6dv73","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210106572","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Helga Guill\u00e9n","raw_affiliation_strings":["Department of Hematology, Hospital Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Spain; and","institution_ids":["https://openalex.org/I4210106572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029022002","display_name":"Anabel Teruel","orcid":"https://orcid.org/0000-0003-1559-7607","observed_orcids":["https://orcid.org/0000-0003-1559-7607"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anabel Teruel","raw_affiliation_strings":["Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Hospital Cl\u00ednico, Valencia, Spain;","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064267997","display_name":"Beatr\u00edz Bellosillo","orcid":"https://orcid.org/0000-0002-5335-2726","observed_orcids":["https://orcid.org/0000-0002-5335-2726"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Bellosillo","raw_affiliation_strings":["Department of Pathology, Hospital del Mar, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital del Mar, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079965975","display_name":"Carmen Burgaleta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106572","display_name":"Hospital Universitario Pr\u00edncipe de Asturias","ror":"https://ror.org/01az6dv73","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210106572","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Burgaleta","raw_affiliation_strings":["Department of Hematology, Hospital Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Spain; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Spain; and","institution_ids":["https://openalex.org/I4210106572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033392955","display_name":"Vicente Vicente","orcid":"https://orcid.org/0000-0002-4278-3264","observed_orcids":["https://orcid.org/0000-0002-4278-3264"]},"institutions":[{"id":"https://openalex.org/I4210091031","display_name":"Hospital General Universitario Morales Meseguer","ror":"https://ror.org/00cfm3y81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210091031"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Vicente","raw_affiliation_strings":["Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Morales Messeguer, Murcia, Spain;","institution_ids":["https://openalex.org/I4210091031"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020155090","display_name":"Carlos Besses","orcid":"https://orcid.org/0000-0003-1806-3440","observed_orcids":["https://orcid.org/0000-0003-1806-3440"]},"institutions":[{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carles Besses","raw_affiliation_strings":["Department of Hematology, Hospital del Mar, Barcelona, Spain;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital del Mar, Barcelona, Spain;","institution_ids":["https://openalex.org/I4210130874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.4777,"has_fulltext":false,"cited_by_count":235,"citation_normalized_percentile":{"value":0.94512828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"119","issue":"6","first_page":"1363","last_page":"1369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":1.0},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.996999979019165},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.765999972820282},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/drug-intolerance","display_name":"drug intolerance","score":0.902999997138977},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5720000267028809},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.656000018119812},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.6800000071525574},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9760000109672546},{"id":"https://openalex.org/keywords/disease-transformation","display_name":"disease transformation","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9293769598007202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7709156274795532},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.6436165571212769},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6244409084320068},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5910922288894653},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5127447843551636},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.5094783902168274},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44098806381225586},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.43137693405151367},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4179065525531769},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.36408907175064087}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2011-10-387787","doi":"https://doi.org/10.1182/blood-2011-10-387787","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2011-10-387787","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:22160617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22160617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1446966563","https://openalex.org/W1521611999","https://openalex.org/W1571858051","https://openalex.org/W1604100901","https://openalex.org/W1968468753","https://openalex.org/W1983819402","https://openalex.org/W1984960437","https://openalex.org/W1996502308","https://openalex.org/W2001901845","https://openalex.org/W2019870759","https://openalex.org/W2025282390","https://openalex.org/W2025614458","https://openalex.org/W2035529203","https://openalex.org/W2038981426","https://openalex.org/W2039403847","https://openalex.org/W2078504876","https://openalex.org/W2086511628","https://openalex.org/W2112316414","https://openalex.org/W2119941797","https://openalex.org/W2133633030","https://openalex.org/W2147416239","https://openalex.org/W2158669800","https://openalex.org/W2159962994","https://openalex.org/W2161951565","https://openalex.org/W4243746858"],"related_works":["https://openalex.org/W2409651431","https://openalex.org/W1506391849","https://openalex.org/W2377532759","https://openalex.org/W297056630","https://openalex.org/W2994410525","https://openalex.org/W2006422832","https://openalex.org/W2054060818","https://openalex.org/W4234221933","https://openalex.org/W2774931754","https://openalex.org/W1971000754"],"abstract_inverted_index":{"Criteria":[0],"of":[1,5,41,58,95,109,118,133,144,197],"response":[2,50,63,69,86,110,171,187],"and":[3,7,48,56,79,120,123,131,154,190,201],"definition":[4,169],"resistance":[6],"intolerance":[8,124],"to":[9,125,137,172,206],"hydroxyurea":[10],"(HU)":[11],"in":[12,27,53,73,87,111,129,180,184,188],"polycythemia":[13],"vera":[14],"(PV)":[15],"were":[16,25,51,195],"proposed":[17],"by":[18],"the":[19,82,167,181],"European":[20],"LeukemiaNet":[21],"(ELN).":[22],"Such":[23],"criteria":[24],"evaluated":[26],"261":[28],"PV":[29],"patients":[30],"(median":[31],"follow-up,":[32],"7.2":[33],"years)":[34],"treated":[35],"with":[36,92,141,177],"HU":[37,126,138,173,207],"for":[38,170],"a":[39,115,178],"median":[40],"4.4":[42],"years.":[43],"Complete":[44],"response,":[45,47],"partial":[46],"no":[49,85],"observed":[52],"24%,":[54],"66%,":[55],"10%":[57],"patients,":[59,134],"respectively.":[60,135,204],"Achieving":[61],"ELN":[62,168],"(complete":[64],"or":[65,67,76],"partial)":[66],"hematocrit":[68],"did":[70],"not":[71,175],"result":[72],"better":[74,202],"survival":[75],"less":[77,198],"thrombosis":[78,119],"bleeding.":[80,121],"On":[81],"contrary,":[83],"having":[84],"leukocyte":[88],"count":[89,113],"was":[90,127,139,174,208],"associated":[91,140,176],"higher":[93,116,142],"risk":[94,117,143],"death":[96,145],"(HR,":[97,146,156],"2.7;":[98],"95%":[99,148,158],"confidence":[100],"interval":[101],"[CI],":[102],"1.3%-5.4%;":[103],"P":[104,151,161],"=":[105],".007),":[106],"whereas":[107,186],"lack":[108],"platelet":[112,189],"involved":[114],"Resistance":[122,136,205],"registered":[128],"11%":[130],"13%":[132],"5.6;":[147],"CI,":[149,159],"2.7%-11.9%;":[150],"<":[152,162],".001)":[153],"transformation":[155],"6.8;":[157],"3.0%-15.4%;":[160],".001).":[163],"In":[164],"summary,":[165],"fulfilling":[166],"benefit":[179],"clinical":[182],"outcome":[183],"PV,":[185],"white":[191],"blood":[192],"cell":[193],"counts":[194],"predictive":[196],"thrombohemorrhagic":[199],"complications":[200],"prognosis,":[203],"an":[209],"adverse":[210],"prognostic":[211],"factor.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
