{"id":"https://openalex.org/W1980970682","doi":"https://doi.org/10.1210/jc.2012-1238","title":"A Systematic Review: Influence of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentration","display_name":"A Systematic Review: Influence of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentration","publication_year":2012,"publication_date":"2012-06-15","ids":{"openalex":"https://openalex.org/W1980970682","doi":"https://doi.org/10.1210/jc.2012-1238","mag":"1980970682","pmid":"https://pubmed.ncbi.nlm.nih.gov/22701014"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2012-1238","doi":"https://doi.org/10.1210/jc.2012-1238","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2012-1238","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044264142","display_name":"Philippe Autier","orcid":"https://orcid.org/0000-0003-1538-5321","observed_orcids":["https://orcid.org/0000-0003-1538-5321"]},"institutions":[{"id":"https://openalex.org/I4210099872","display_name":"International Prevention Research Institute","ror":"https://ror.org/011ssy811","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210099872"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Philippe Autier","raw_affiliation_strings":["International Prevention Research Institute, Lyon, France. philippe.autier@i-pri.org","International Prevention Research Institute (P.A., P.M.), 69006 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Prevention Research Institute, Lyon, France. philippe.autier@i-pri.org","institution_ids":["https://openalex.org/I4210099872"]},{"raw_affiliation_string":"International Prevention Research Institute (P.A., P.M.), 69006 Lyon, France","institution_ids":["https://openalex.org/I4210099872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015077519","display_name":"Sara Gandini","orcid":"https://orcid.org/0000-0002-1348-4548","observed_orcids":["https://orcid.org/0000-0002-1348-4548"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Gandini","raw_affiliation_strings":["European Institute of Oncology (S.G.), 20139 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Institute of Oncology (S.G.), 20139 Milano, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106512522","display_name":"Patrick Mullie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099872","display_name":"International Prevention Research Institute","ror":"https://ror.org/011ssy811","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210099872"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Mullie","raw_affiliation_strings":["International Prevention Research Institute (P.A., P.M.), 69006 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Prevention Research Institute (P.A., P.M.), 69006 Lyon, France","institution_ids":["https://openalex.org/I4210099872"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044264142"],"corresponding_institution_ids":["https://openalex.org/I4210099872"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.3734,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.90268199,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"97","issue":"8","first_page":"2606","last_page":"2613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":1.0},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.8820000290870667},{"id":"https://openalex.org/keywords/vitamin-d2","display_name":"vitamin D2","score":1.0},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7419999837875366},{"id":"https://openalex.org/keywords/serum-vitamin-d-levels","display_name":"serum vitamin D levels","score":0.7110000252723694},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7879999876022339},{"id":"https://openalex.org/keywords/baseline-vitamin-d-status","display_name":"baseline vitamin D status","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.8851380944252014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7596414089202881},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7524713277816772},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.6356605291366577},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6174610257148743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.572913646697998},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5312219858169556},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.5111022591590881},{"id":"https://openalex.org/C2777621572","wikidata":"https://www.wikidata.org/wiki/Q139200","display_name":"Ergocalciferol","level":4,"score":0.44702979922294617},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4389728605747223},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40193697810173035},{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.3854474127292633},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.328786164522171},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05780160427093506},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/jc.2012-1238","doi":"https://doi.org/10.1210/jc.2012-1238","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2012-1238","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:22701014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22701014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01262994v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01262994","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Endocrinol Metab, 2012, 97 (8), pp.2606-13. ⟨10.1210/jc.2012-1238⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:80026","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/a-systematic-review--influence-of-vitamin-d-supplementation-on-serum-25hydroxyvitamin-d-concentration(3b4bd7b3-8806-4a7c-8baf-8a0bda40ded6).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W221858366","https://openalex.org/W1564323166","https://openalex.org/W1940281156","https://openalex.org/W1968140022","https://openalex.org/W1972991194","https://openalex.org/W1974125594","https://openalex.org/W1979327418","https://openalex.org/W2000442546","https://openalex.org/W2007593363","https://openalex.org/W2011411081","https://openalex.org/W2024208347","https://openalex.org/W2028903163","https://openalex.org/W2029644930","https://openalex.org/W2036841307","https://openalex.org/W2053727263","https://openalex.org/W2058871858","https://openalex.org/W2072271529","https://openalex.org/W2072975437","https://openalex.org/W2077040550","https://openalex.org/W2096150705","https://openalex.org/W2101805185","https://openalex.org/W2107072401","https://openalex.org/W2109253309","https://openalex.org/W2109452366","https://openalex.org/W2123038181","https://openalex.org/W2123457747","https://openalex.org/W2126082097","https://openalex.org/W2126602143","https://openalex.org/W2130265167","https://openalex.org/W2131264460","https://openalex.org/W2133403604","https://openalex.org/W2153721027","https://openalex.org/W2156394393","https://openalex.org/W2157304718","https://openalex.org/W2159722563","https://openalex.org/W2162139093","https://openalex.org/W2237938271","https://openalex.org/W2321873428","https://openalex.org/W2395085828","https://openalex.org/W4233228028","https://openalex.org/W4234762277","https://openalex.org/W4252973580"],"related_works":["https://openalex.org/W4400286496","https://openalex.org/W4414380223","https://openalex.org/W4386782359","https://openalex.org/W2042598607","https://openalex.org/W2154541156","https://openalex.org/W2913681752","https://openalex.org/W2166670479","https://openalex.org/W2921225437","https://openalex.org/W4415646747","https://openalex.org/W4392505007"],"abstract_inverted_index":{"CONTEXT:":[0],"Few":[1],"studies":[2],"in":[3,33,43,57,61,86,144,159,171,224,242],"subjects":[4,45,118],"over":[5,46],"50":[6,47],"yr":[7,48],"of":[8,14,17,31,63,77,162,165,183,208],"age":[9],"have":[10],"evaluated":[11,74],"the":[12,75,87,104,160,168,191,194,250],"influence":[13,76],"variable":[15],"doses":[16,127],"vitamin":[18,40,78,184,192,195,235,257],"D":[19,24,36,41,79,98,146,174,214,226,236,245],"supplementation":[20,42,80,210,237],"on":[21,81,234,256],"serum":[22,96,172],"25-hydroxyvitamin":[23,35,97,145,173,213,225,244],"levels.":[25],"OBJECTIVE:":[26],"We":[27,52,91],"performed":[28],"a":[29,54],"meta-analysis":[30],"changes":[32],"circulating":[34,243],"level":[37],"associated":[38,198,220],"with":[39,199,221],"Caucasian":[44],"old.":[49],"DATA":[50,89,106],"SOURCES:":[51],"conducted":[53],"systematic":[55],"search":[56],"literature":[58],"databases":[59],"and":[60,95,102,211,231],"references":[62],"past":[64],"reviews.":[65],"STUDY":[66],"SELECTION:":[67],"Randomized":[68],"placebo":[69],"or":[70],"open-label":[71],"trials":[72,109,140,233,255],"that":[73,124,158],"clinical":[82],"outcomes":[83],"were":[84],"included":[85,116],"study.":[88],"EXTRACTION:":[90],"reviewed":[92],"trial":[93],"characteristics":[94],"concentrations":[99,175],"at":[100,216],"baseline":[101,217],"during":[103],"trial.":[105],"SYNTHESIS:":[107],"Seventy-six":[108],"published":[110],"from":[111,129],"1984":[112],"to":[113,120,131,148,190],"March":[114],"2011":[115],"6207":[117],"allocated":[119],"101":[121],"intervention":[122],"groups":[123],"tested":[125],"supplement":[126,186],"ranging":[128],"5":[130],"250":[132],"\u03bcg/d":[133],"(median,":[134],"20":[135],"\u03bcg/d).":[136],"For":[137],"similar":[138],"doses,":[139],"could":[141],"obtain":[142],"increases":[143,202,223,241,252],"three":[147],"four":[149],"times":[150],"lower":[151,201,222],"than":[152],"other":[153],"trials.":[154],"A":[155],"meta-regression":[156],"showed":[157],"absence":[161],"concomitant":[163,260],"use":[164,207],"calcium":[166,209,261],"supplements,":[167],"average":[169,251],"increase":[170],"was":[176,197,218],"0.78":[177],"ng/ml":[178],"(1.95":[179],"nmol/liter)":[180],"per":[181,187],"microgram":[182],"D3":[185,258],"day.":[188],"Compared":[189],"D3,":[193],"D2":[196],"significantly":[200],"(P":[203],"=":[204],"0.03).":[205],"Concomitant":[206],"high":[212],"concentration":[215],"nonsignificantly":[219],"concentrations.":[227],"CONCLUSIONS:":[228],"Dietary":[229],"recommendations":[230],"randomized":[232],"should":[238],"evaluate":[239],"whether":[240],"levels":[246],"match":[247],"expectations--for":[248],"instance,":[249],"obtained":[253],"by":[254],"without":[259],"supplements.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}