{"id":"https://openalex.org/W1980933786","doi":"https://doi.org/10.1097/00024382-200207000-00009","title":"Epinephrine as a Mediator of Pulmonary Neutrophil Sequestration","display_name":"Epinephrine as a Mediator of Pulmonary Neutrophil Sequestration","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W1980933786","doi":"https://doi.org/10.1097/00024382-200207000-00009","mag":"1980933786","pmid":"https://pubmed.ncbi.nlm.nih.gov/12095133"},"language":"en","primary_location":{"id":"doi:10.1097/00024382-200207000-00009","doi":"https://doi.org/10.1097/00024382-200207000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-200207000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006591542","display_name":"Jeffrey J. Morken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey J. Morken","raw_affiliation_strings":["Hennepin County Medical Center, Minneapolis, Minnesota 55404, USA","Hennepin County Medical Center, Minneapolis, Minnesota 55404","accepted in final form 15 Aug 2001","first review completed 25 May 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404, USA","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"first review completed 25 May 2001","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014804687","display_name":"Krista Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista U. Warren","raw_affiliation_strings":["Hennepin County Medical Center, Minneapolis, Minnesota 55404","first review completed 25 May 2001; accepted in final form 15 Aug 2001","accepted in final form 15 Aug 2001","first review completed 25 May 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"first review completed 25 May 2001; accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"first review completed 25 May 2001","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002655394","display_name":"Yonghong Xie","orcid":"https://orcid.org/0000-0003-0865-7317","observed_orcids":["https://orcid.org/0000-0003-0865-7317"]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yonghong Xie","raw_affiliation_strings":["Hennepin County Medical Center, Minneapolis, Minnesota 55404","first review completed 25 May 2001; accepted in final form 15 Aug 2001","accepted in final form 15 Aug 2001","first review completed 25 May 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"first review completed 25 May 2001; accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"first review completed 25 May 2001","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082858","display_name":"Jorge L. Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge L. Rodriguez","raw_affiliation_strings":["Hennepin County Medical Center, Minneapolis, Minnesota 55404","first review completed 25 May 2001; accepted in final form 15 Aug 2001","accepted in final form 15 Aug 2001","first review completed 25 May 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"first review completed 25 May 2001; accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"first review completed 25 May 2001","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055994217","display_name":"Mark Lyte","orcid":"https://orcid.org/0000-0001-8512-2581","observed_orcids":["https://orcid.org/0000-0001-8512-2581"]},"institutions":[{"id":"https://openalex.org/I2802288015","display_name":"Hennepin County Medical Center","ror":"https://ror.org/01k7a6660","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802288015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Lyte","raw_affiliation_strings":["Address reprint requests to Mark Lyte, PhD, Department of Surgery, Hennepin County Medical Center, Minneapolis Medical Research Foundation, 914 South 8th Street, D3, Minneapolis, MN 55404","Hennepin County Medical Center, Minneapolis, Minnesota 55404","first review completed 25 May 2001; accepted in final form 15 Aug 2001","accepted in final form 15 Aug 2001","first review completed 25 May 2001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Mark Lyte, PhD, Department of Surgery, Hennepin County Medical Center, Minneapolis Medical Research Foundation, 914 South 8th Street, D3, Minneapolis, MN 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"Hennepin County Medical Center, Minneapolis, Minnesota 55404","institution_ids":["https://openalex.org/I2802288015"]},{"raw_affiliation_string":"first review completed 25 May 2001; accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"accepted in final form 15 Aug 2001","institution_ids":[]},{"raw_affiliation_string":"first review completed 25 May 2001","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802288015"],"apc_list":null,"apc_paid":null,"fwci":0.546,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.70082306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"1","first_page":"46","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":1.0},{"id":"https://openalex.org/keywords/neutrophil-accumulation","display_name":"neutrophil accumulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.890999972820282},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.8429999947547913},{"id":"https://openalex.org/keywords/neutrophil-mediated-lung-injury","display_name":"neutrophil-mediated lung injury","score":0.8939999938011169},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.5249999761581421},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.8680848479270935},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.6904995441436768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6724064946174622},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6543757319450378},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6132473945617676},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6042994856834412},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5366536974906921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4509911835193634},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.43644893169403076},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39820441603660583},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2907906174659729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001998","descriptor_name":"Bronchopulmonary Sequestration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00024382-200207000-00009","doi":"https://doi.org/10.1097/00024382-200207000-00009","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-200207000-00009","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:12095133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12095133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W162615482","https://openalex.org/W189122608","https://openalex.org/W1521933398","https://openalex.org/W1522730425","https://openalex.org/W1965737875","https://openalex.org/W1974001553","https://openalex.org/W1979447888","https://openalex.org/W1984345127","https://openalex.org/W1988631824","https://openalex.org/W1996387186","https://openalex.org/W2004973778","https://openalex.org/W2007388328","https://openalex.org/W2007982869","https://openalex.org/W2023119268","https://openalex.org/W2027113170","https://openalex.org/W2033241814","https://openalex.org/W2050707064","https://openalex.org/W2072214664","https://openalex.org/W2072622532","https://openalex.org/W2074419421","https://openalex.org/W2092917836","https://openalex.org/W2093057855","https://openalex.org/W2094644303","https://openalex.org/W2100128400","https://openalex.org/W2109355027","https://openalex.org/W2114819441","https://openalex.org/W2121746820","https://openalex.org/W2128814422","https://openalex.org/W2148000616","https://openalex.org/W2257233909","https://openalex.org/W2259360596","https://openalex.org/W2262126354","https://openalex.org/W2272555990"],"related_works":["https://openalex.org/W2415251319","https://openalex.org/W2058135314","https://openalex.org/W1983356468","https://openalex.org/W2047483162","https://openalex.org/W1831064357","https://openalex.org/W2150110104","https://openalex.org/W1543911011","https://openalex.org/W1984757410","https://openalex.org/W2418215335","https://openalex.org/W4313376921"],"abstract_inverted_index":{"Neutrophil-mediated":[0],"lung":[1,88,114,234,261],"injury":[2],"is":[3,17,104],"a":[4,99,119,130,150],"potential":[5],"complication":[6],"of":[7,24,31,43,60,77,113,134,143,161,205,213,223,258],"trauma":[8,13,32,251],"and":[9,14,20,87,89],"sepsis.":[10],"Concomitant":[11],"with":[12,57,138,187],"sepsis,":[15,34],"there":[16],"an":[18,105,202],"immediate":[19],"sustained":[21],"systemic":[22],"elevation":[23],"catecholamines":[25],"including":[26],"epinephrine.":[27],"In":[28,210],"the":[29,41,46,75,123,211,221,238,254],"absence":[30,212],"or":[33,63,216],"we":[35],"examined":[36],"whether":[37],"epinephrine":[38,64,126,162,218,248],"contributes":[39],"to":[40,49,73,122],"accumulation":[42,94,133,155,166,222],"neutrophils":[44,136,224],"in":[45,129,149,195,220,225,250],"lung.":[47],"Eight-":[48],"12-week-old":[50],"male":[51],"CF-1":[52],"mice":[53],"were":[54,81,91,167,174,191],"injected":[55],"i.p.":[56,78],"0.2":[58],"mL":[59],"normal":[61,139,144],"saline":[62,145],"(0.1-5.0":[65],"mg/kg).":[66],"An":[67],"unmanipulated":[68,157],"control":[69],"group":[70],"was":[71,95,116],"included":[72],"examine":[74],"stress":[76,142],"injection.":[79],"Animals":[80],"sacrificed":[82],"at":[83,169],"predetermined":[84],"time":[85],"points,":[86],"spleen":[90,196],"harvested.":[92],"PMN":[93],"assessed":[96],"by":[97,118,181],"using":[98],"myeloperoxidase":[100],"(MPO)":[101],"assay,":[102],"which":[103],"indirect":[106],"marker":[107],"for":[108,256],"neutrophil":[109,154,165,208,235],"presence.":[110],"Morphometric":[111],"analysis":[112],"tissue":[115],"performed":[117],"pathologist":[120],"blinded":[121],"groups.":[124],"Increasing":[125],"doses":[127],"resulted":[128,148],"significantly":[131,151,176],"increased":[132,233],"pulmonary":[135,153,164,207],"compared":[137],"saline.":[140],"The":[141,159,228],"injection":[146],"also":[147],"greater":[152],"than":[156],"controls.":[158],"effects":[160],"on":[163],"greatest":[168],"2":[170],"h,":[171],"but":[172],"they":[173],"not":[175],"different":[177],"from":[178],"saline-injected":[179],"controls":[180],"12":[182],"h.":[183],"These":[184],"results":[185,219],"correlated":[186],"histological":[188],"analysis.":[189],"There":[190],"no":[192],"significant":[193],"differences":[194],"MPO":[197],"activity":[198],"between":[199],"groups,":[200],"suggesting":[201],"organ-specific":[203],"mechanism":[204,242],"epinephrine-induced":[206],"sequestration.":[209],"trauma,":[214],"shock,":[215],"infection,":[217],"murine":[226],"lungs.":[227],"finding":[229],"that":[230,240],"\"injection":[231],"stress\"":[232],"sequestration":[236],"suggests":[237],"possibility":[239],"this":[241],"may":[243,252],"be":[244],"physiologically":[245],"relevant.":[246],"Thus,":[247],"release":[249],"set":[253],"stage":[255],"development":[257],"neutrophil-mediated":[259],"acute":[260],"injury.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}