{"id":"https://openalex.org/W1980840240","doi":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","title":"Effects of Chronic Ethanol Treatment on the \u03b2\u2010Adrenergic Receptor\u2010Coupled Adenylate Cyclase System of Mouse Cerebral Cortex","display_name":"Effects of Chronic Ethanol Treatment on the \u03b2\u2010Adrenergic Receptor\u2010Coupled Adenylate Cyclase System of Mouse Cerebral Cortex","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W1980840240","doi":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","mag":"1980840240","pmid":"https://pubmed.ncbi.nlm.nih.gov/3033151"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1987.tb05741.x","doi":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110703922","display_name":"Toshikazu Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Toshikazu Saito","raw_affiliation_strings":["Alcohol and Drug Abuse Research and Training Program, Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol and Drug Abuse Research and Training Program, Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000331309","display_name":"John Michael Lee","orcid":"https://orcid.org/0000-0001-8473-4674","observed_orcids":["https://orcid.org/0000-0001-8473-4674"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Lee","raw_affiliation_strings":["Alcohol and Drug Abuse Research and Training Program, Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, Chicago, Illinois, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alcohol and Drug Abuse Research and Training Program, Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, Chicago, Illinois, U.S.A","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108196798","display_name":"Paula L. Hoffman","orcid":"https://orcid.org/0000-0002-6443-4225","observed_orcids":["https://orcid.org/0000-0002-6443-4225"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula L. Hoffman","raw_affiliation_strings":["National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic and Pharmacologic Studies, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic and Pharmacologic Studies, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014576325","display_name":"Boris Tabakoff","orcid":"https://orcid.org/0000-0001-5132-5030","observed_orcids":["https://orcid.org/0000-0001-5132-5030"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Tabakoff","raw_affiliation_strings":["National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic and Pharmacologic Studies, National Institutes of Health, Bethesda, Maryland, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Alcohol Abuse and Alcoholism, Laboratory of Physiologic and Pharmacologic Studies, National Institutes of Health, Bethesda, Maryland, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110703922"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.2072,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.88356933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"6","first_page":"1817","last_page":"1822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-alcohol-exposure","display_name":"chronic ethanol exposure","score":0.9240000247955322},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9100000262260437},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.972000002861023},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.843999981880188},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.8669999837875366},{"id":"https://openalex.org/keywords/gpp-nh-p","display_name":"Gpp(NH)p","score":0.8090000152587891},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8759999871253967},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ethanol-tolerance","display_name":"ethanol tolerance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ethanol-dependence","display_name":"ethanol dependence","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.8978298902511597},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.8733872175216675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7261002659797668},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7187698483467102},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5861386656761169},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5495615005493164},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5165404677391052},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49808192253112793},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.41073596477508545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3016277551651001},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29548418521881104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09667831659317017}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006165","descriptor_name":"Guanylyl Imidodiphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1987.tb05741.x","doi":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1987.tb05741.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:3033151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3033151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2043466603","display_name":null,"funder_award_id":"AA2696","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1493609355","https://openalex.org/W1532747508","https://openalex.org/W1570939625","https://openalex.org/W1600624424","https://openalex.org/W1775749144","https://openalex.org/W1902984408","https://openalex.org/W1926401086","https://openalex.org/W1933709061","https://openalex.org/W1944391672","https://openalex.org/W1980185263","https://openalex.org/W2038021560","https://openalex.org/W2049296045","https://openalex.org/W2107163988","https://openalex.org/W2128624418","https://openalex.org/W2169503005","https://openalex.org/W2172509713","https://openalex.org/W2222808899","https://openalex.org/W2244983727","https://openalex.org/W2301918850","https://openalex.org/W2346424288","https://openalex.org/W2366040490","https://openalex.org/W2409689425","https://openalex.org/W2418271042"],"related_works":["https://openalex.org/W2054529939","https://openalex.org/W2418077496","https://openalex.org/W2064498397","https://openalex.org/W2135714150","https://openalex.org/W1970268624","https://openalex.org/W2128624418","https://openalex.org/W2164894518","https://openalex.org/W2086411670","https://openalex.org/W2030924444","https://openalex.org/W1985138921"],"abstract_inverted_index":{"Chronic":[0],"ingestion":[1],"of":[2,14,39,45,61,78,86,103,125,158],"ethanol,":[3],"which":[4],"produced":[5],"tolerance":[6,170],"and":[7,72,97,162],"physical":[8],"dependence,":[9],"resulted":[10],"in":[11,23,30,36,59,66,75,83,109,122,135],"altered":[12],"function":[13,124],"the":[15,37,40,50,76,90,98,123,126,136],"cerebral":[16],"cortical":[17,84],"beta-adrenergic":[18,137],"receptor-coupled":[19],"adenylate":[20,32,46,69,104],"cyclase":[21,33,47,70,105],"system":[22],"mice.":[24,88],"Although":[25],"there":[26],"was":[27,57,80,95,107],"no":[28],"change":[29],"basal":[31],"activity,":[34,71],"or":[35,119,169],"activity":[38,48,106],"digitonin-solubilized":[41],"catalytic":[42],"unit,":[43],"stimulation":[44,102],"by":[49],"nonhydrolyzable":[51],"guanine":[52,128],"nucleotide":[53],"analog":[54],"guanylylimidodiphosphate":[55],"[Gpp(NH)p]":[56],"reduced":[58,82],"brains":[60],"ethanol-fed":[62,87,110],"animals.":[63,111],"Ethanol":[64],"added":[65],"vitro":[67],"increased":[68,108],"this":[73],"enhancement,":[74],"presence":[77],"Gpp(NH)p,":[79],"also":[81],"membranes":[85],"Furthermore,":[89],"maximal":[91],"response":[92],"to":[93,148,151,171],"isoproterenol":[94,101],"decreased,":[96],"EC50":[99],"for":[100],"The":[112],"results":[113],"are":[114],"consistent":[115],"with":[116,166],"a":[117],"qualitative":[118],"quantitative":[120],"defect":[121],"stimulatory":[127],"nucleotide-binding":[129],"protein":[130],"(Ns),":[131],"as":[132,134],"well":[133],"receptor,":[138],"after":[139],"chronic":[140],"ethanol":[141],"exposure.":[142],"In":[143],"part,":[144],"these":[145],"changes":[146],"appear":[147],"be":[149,164],"similar":[150],"those":[152],"that":[153],"occur":[154],"during":[155],"heterologous":[156],"desensitization":[157],"various":[159],"receptor":[160],"systems,":[161],"may":[163],"associated":[165],"dependence":[167],"on":[168],"ethanol.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
