{"id":"https://openalex.org/W1980782864","doi":"https://doi.org/10.1093/jac/40.5.615","title":"Natural release of virulence factors in membrane vesicles by Pseudomonas aeruginosa and the effect of aminoglycoside antibiotics on their release","display_name":"Natural release of virulence factors in membrane vesicles by Pseudomonas aeruginosa and the effect of aminoglycoside antibiotics on their release","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W1980782864","doi":"https://doi.org/10.1093/jac/40.5.615","mag":"1980782864","pmid":"https://pubmed.ncbi.nlm.nih.gov/9421308"},"language":"en","primary_location":{"id":"doi:10.1093/jac/40.5.615","doi":"https://doi.org/10.1093/jac/40.5.615","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/40.5.615","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1980782864"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004001758","display_name":"Jagath L. Kadurugamuwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"J. Kadurugamuwa","raw_affiliation_strings":["Department of Microbiology, College of Biological Science, University of Guelph, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, College of Biological Science, University of Guelph, Ontario, Canada","institution_ids":["https://openalex.org/I79817857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161594423","display_name":"T J Beveridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Beveridge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004001758"],"corresponding_institution_ids":["https://openalex.org/I79817857"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.3891,"has_fulltext":false,"cited_by_count":207,"citation_normalized_percentile":{"value":0.80058227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"40","issue":"5","first_page":"615","last_page":"621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5282999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.07190000265836716,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.996999979019165},{"id":"https://openalex.org/keywords/membrane-vesicles","display_name":"membrane vesicles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":1.0},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8949999809265137},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.8009999990463257},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.6549999713897705},{"id":"https://openalex.org/keywords/membrane-perturbation","display_name":"membrane perturbation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cell-lysis","display_name":"cell lysis","score":0.625},{"id":"https://openalex.org/keywords/antibiotic-toxicity","display_name":"antibiotic toxicity","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.6874502897262573},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.67598956823349},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6301698684692383},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.6100619435310364},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.585081934928894},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.5407105088233948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49749472737312317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4937194287776947},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.45977696776390076},{"id":"https://openalex.org/C2781427627","wikidata":"https://www.wikidata.org/wiki/Q410503","display_name":"Pyocyanin","level":5,"score":0.4311411380767822},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3503434658050537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33986765146255493},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3094859719276428},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.30647820234298706},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.2698271870613098},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.08444225788116455},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jac/40.5.615","doi":"https://doi.org/10.1093/jac/40.5.615","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/40.5.615","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:9421308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9421308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W17244967","https://openalex.org/W174814383","https://openalex.org/W311878970","https://openalex.org/W648438745","https://openalex.org/W1620716033","https://openalex.org/W1931126129","https://openalex.org/W1942022395","https://openalex.org/W1960877698","https://openalex.org/W1967233831","https://openalex.org/W1979356356","https://openalex.org/W1983737724","https://openalex.org/W2011239236","https://openalex.org/W2014035141","https://openalex.org/W2020548481","https://openalex.org/W2026708198","https://openalex.org/W2029374586","https://openalex.org/W2031943238","https://openalex.org/W2041652393","https://openalex.org/W2049710076","https://openalex.org/W2050066786","https://openalex.org/W2054873820","https://openalex.org/W2055875742","https://openalex.org/W2058389188","https://openalex.org/W2079071720","https://openalex.org/W2083392007","https://openalex.org/W2093783208","https://openalex.org/W2098294680","https://openalex.org/W2110876099","https://openalex.org/W2140375197","https://openalex.org/W2170420329","https://openalex.org/W2295831751","https://openalex.org/W2315401467","https://openalex.org/W2320676858","https://openalex.org/W2323779084","https://openalex.org/W2399048800","https://openalex.org/W2407502038","https://openalex.org/W2417641236","https://openalex.org/W2485732558","https://openalex.org/W2497590435"],"related_works":["https://openalex.org/W2110313414","https://openalex.org/W2104837454","https://openalex.org/W3004892168","https://openalex.org/W1999044149","https://openalex.org/W1969218547","https://openalex.org/W2089462559","https://openalex.org/W416657375","https://openalex.org/W2073521181","https://openalex.org/W7098562356","https://openalex.org/W2112865125"],"abstract_inverted_index":{"Pseudomonas":[0],"aeruginosa":[1],"(and":[2],"various":[3],"other":[4],"gram-negative":[5],"pathogens)":[6],"liberate":[7],"membrane":[8,21,142,181],"vesicles":[9,15,38,69,182],"during":[10,197],"normal":[11],"growth.":[12],"These":[13],"bilayered":[14,126],"consist":[16],"of":[17,63,72,77,122,162,173,180,192],"endotoxin":[18],"(lipopolysaccharide),":[19],"outer":[20],"proteins":[22],"and":[23,34,41,48,80,166],"several":[24],"potent":[25],"hydrolytic":[26],"enzymes":[27],"including":[28],"protease,":[29],"alkaline":[30,42],"phosphatase,":[31],"phospholipase":[32],"C":[33],"peptidoglycan":[35],"hydrolase.":[36],"The":[37,99],"contain":[39],"pro-elastase":[40],"phosphatase":[43],"(which":[44],"are":[45,50,58,70,156],"periplasmic":[46,54],"constituents)":[47],"so":[49,146],"important":[51],"for":[52,190],"packaging":[53],"components":[55],"as":[56,138],"they":[57,89],"liberated":[59],"to":[60,105,184],"the":[61,64,68,75,97,119,171,178,193],"outside":[62],"cell.":[65],"Once":[66],"liberated,":[67],"capable":[71],"fusing":[73],"with":[74,130,200],"membranes":[76,172],"epithelial":[78],"cells":[79,87,155],"liberating":[81],"their":[82,135],"virulence":[83],"factors":[84],"into":[85],"host":[86],"where":[88],"degrade":[90],"cellular":[91],"components,":[92],"thereby":[93,124],"aiding":[94],"infection":[95],"by":[96,108,159],"pathogen.":[98],"aminoglycoside":[100,201],"antibiotic,":[101],"gentamicin,":[102],"is":[103],"thought":[104],"kill":[106],"bacteria":[107],"inhibiting":[109],"protein":[110,163],"synthesis,":[111],"yet":[112],"this":[113,141],"cationic":[114],"antibiotic":[115],"can":[116,144,150],"also":[117],"perturb":[118],"packing":[120],"order":[121],"lipids,":[123],"destabilizing":[125,170],"membranes.":[127],"For":[128],"pathogens":[129],"highly":[131],"anionic":[132],"lipopolysaccharide":[133],"on":[134],"surface,":[136],"such":[137],"P.":[139,174],"aeruginosa,":[140,175],"destabilization":[143],"be":[145],"serious":[147],"that":[148],"it":[149],"cause":[151],"cell":[152],"lysis;":[153],"these":[154],"therefore":[157],"killed":[158],"a":[160],"combination":[161],"synthesis":[164],"inhibition":[165],"surface":[167],"perturbation.":[168],"By":[169],"gentamicin":[176],"increases":[177],"release":[179],"three-":[183],"five-fold.":[185],"This":[186],"may":[187],"help":[188],"account":[189],"some":[191],"bacterium-mediated":[194],"toxicity":[195],"encountered":[196],"patient":[198],"treatment":[199],"antibiotics.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
