{"id":"https://openalex.org/W1980765494","doi":"https://doi.org/10.1210/en.2012-1591","title":"Mammary Gland Morphology and Gene Expression Differ in Female Rats Treated with 17\u03b2-Estradiol or Fed Soy Protein Isolate","display_name":"Mammary Gland Morphology and Gene Expression Differ in Female Rats Treated with 17\u03b2-Estradiol or Fed Soy Protein Isolate","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W1980765494","doi":"https://doi.org/10.1210/en.2012-1591","mag":"1980765494","pmid":"https://pubmed.ncbi.nlm.nih.gov/23027806"},"language":"en","primary_location":{"id":"doi:10.1210/en.2012-1591","doi":"https://doi.org/10.1210/en.2012-1591","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2012-1591","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041753848","display_name":"Martin J. J. Ronis","orcid":"https://orcid.org/0000-0002-0116-3771","observed_orcids":["https://orcid.org/0000-0002-0116-3771"]},"institutions":[{"id":"https://openalex.org/I4210146069","display_name":"Arkansas Children's Nutrition Center","ror":"https://ror.org/03vvhya80","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210122704","https://openalex.org/I4210146069"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J. J. Ronis","raw_affiliation_strings":["Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. RonisMartinJ@uams.edu","Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA. RonisMartinJ@uams.edu","institution_ids":["https://openalex.org/I4210146069"]},{"raw_affiliation_string":"Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA","institution_ids":["https://openalex.org/I4210146069"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035081477","display_name":"Kartik Shankar","orcid":"https://orcid.org/0000-0002-7964-9026","observed_orcids":["https://orcid.org/0000-0002-7964-9026"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartik Shankar","raw_affiliation_strings":["Pediatrics (M.J.J.R., K.S., H.G.-A., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics (M.J.J.R., K.S., H.G.-A., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056294115","display_name":"Horacio G\u00f3mez-Acevedo","orcid":"https://orcid.org/0000-0002-1570-1606","observed_orcids":["https://orcid.org/0000-0002-1570-1606"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Horacio Gomez-Acevedo","raw_affiliation_strings":["Pediatrics (M.J.J.R., K.S., H.G.-A., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics (M.J.J.R., K.S., H.G.-A., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013397406","display_name":"Leah J. Hennings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Hennings","raw_affiliation_strings":["Pathology (L.H.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology (L.H.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109035452","display_name":"Rohit Singhal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohit Singhal","raw_affiliation_strings":["Departments of Pharmacology and Toxicology (M.J.J.R., R.S.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Toxicology (M.J.J.R., R.S.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064881126","display_name":"Michael L. Blackburn","orcid":"https://orcid.org/0000-0002-4126-3750","observed_orcids":["https://orcid.org/0000-0002-4126-3750"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Blackburn","raw_affiliation_strings":["Physiology and Biophysics (M.L.B., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics (M.L.B., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076259954","display_name":"Thomas M. Badger","orcid":"https://orcid.org/0000-0003-1159-7191","observed_orcids":["https://orcid.org/0000-0003-1159-7191"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Badger","raw_affiliation_strings":["Physiology and Biophysics (M.L.B., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics (M.L.B., T.M.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.3814,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80292511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"153","issue":"12","first_page":"6021","last_page":"6032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soy-protein-isolate","display_name":"soy protein isolate","score":0.8299999833106995},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.7609999775886536},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.9070000052452087},{"id":"https://openalex.org/keywords/estrogenic-activity","display_name":"estrogenic activity","score":0.777999997138977},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mammary-gland-morphology","display_name":"mammary gland morphology","score":0.7760000228881836},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.996999979019165},{"id":"https://openalex.org/keywords/ovariectomized-rats","display_name":"ovariectomized rats","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8004814386367798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7717252373695374},{"id":"https://openalex.org/C2777014122","wikidata":"https://www.wikidata.org/wiki/Q7571993","display_name":"Soy protein","level":2,"score":0.7219253182411194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6255035400390625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5927119255065918},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.5625961422920227},{"id":"https://openalex.org/C2778270713","wikidata":"https://www.wikidata.org/wiki/Q414496","display_name":"Phytoestrogens","level":3,"score":0.4824734032154083},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.46453410387039185},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.4470486640930176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44521576166152954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42466315627098083},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3215157687664032},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.2768051028251648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1182955801486969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08721745014190674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002364","descriptor_name":"Caseins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030262","descriptor_name":"Soybean Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/en.2012-1591","doi":"https://doi.org/10.1210/en.2012-1591","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2012-1591","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:23027806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23027806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W154734720","https://openalex.org/W1495772368","https://openalex.org/W1894768384","https://openalex.org/W1898962100","https://openalex.org/W1925222957","https://openalex.org/W1950805987","https://openalex.org/W1971930482","https://openalex.org/W1978094794","https://openalex.org/W1979648005","https://openalex.org/W1981905991","https://openalex.org/W1987878422","https://openalex.org/W1990651658","https://openalex.org/W1991455388","https://openalex.org/W2001177910","https://openalex.org/W2009527950","https://openalex.org/W2013864031","https://openalex.org/W2015938432","https://openalex.org/W2018590902","https://openalex.org/W2026836636","https://openalex.org/W2040837954","https://openalex.org/W2040851511","https://openalex.org/W2044817965","https://openalex.org/W2046529862","https://openalex.org/W2048732074","https://openalex.org/W2049065322","https://openalex.org/W2049970571","https://openalex.org/W2059113657","https://openalex.org/W2063576046","https://openalex.org/W2067382565","https://openalex.org/W2067920028","https://openalex.org/W2068104926","https://openalex.org/W2073718466","https://openalex.org/W2074846025","https://openalex.org/W2083188840","https://openalex.org/W2085240103","https://openalex.org/W2085703900","https://openalex.org/W2096588215","https://openalex.org/W2108802209","https://openalex.org/W2109555266","https://openalex.org/W2111178814","https://openalex.org/W2113038168","https://openalex.org/W2113979917","https://openalex.org/W2116405797","https://openalex.org/W2116483670","https://openalex.org/W2118633617","https://openalex.org/W2121454015","https://openalex.org/W2122221269","https://openalex.org/W2125163646","https://openalex.org/W2129612118","https://openalex.org/W2130289865","https://openalex.org/W2134247733","https://openalex.org/W2141060847","https://openalex.org/W2141212104","https://openalex.org/W2147968542","https://openalex.org/W2148458324","https://openalex.org/W2149836519","https://openalex.org/W2156218663","https://openalex.org/W2159608867","https://openalex.org/W2164620234","https://openalex.org/W2165229748","https://openalex.org/W2165937121","https://openalex.org/W2169328139","https://openalex.org/W2169917918","https://openalex.org/W2474761801"],"related_works":["https://openalex.org/W3166538420","https://openalex.org/W2133197996","https://openalex.org/W1527063362","https://openalex.org/W2096588215","https://openalex.org/W2290447691","https://openalex.org/W147570737","https://openalex.org/W3173647296","https://openalex.org/W1562009702","https://openalex.org/W3174602668","https://openalex.org/W4406286719"],"abstract_inverted_index":{"Soy":[0],"foods":[1,30],"have":[2,6],"been":[3],"suggested":[4],"to":[5,115,133,144,150,185,236],"both":[7,245],"positive":[8],"health":[9],"benefits":[10],"and":[11,60,89,157,164,181,192,203,240,247],"potentially":[12],"adverse":[13],"effects":[14,38,167],"as":[15],"a":[16],"result":[17],"of":[18,21,28,39,52,108,125,154,161,212,234,272],"their":[19],"content":[20],"phytoestrogens.":[22],"However,":[23],"studies":[24],"on":[25,55,78,85,168,189],"the":[26,37,44,63,136,175,190,210,217,223,232,264,270],"estrogenicity":[27],"soy":[29,40,47],"are":[31],"lacking.":[32],"Here":[33],"we":[34],"directly":[35],"compared":[36],"protein":[41,45],"isolate":[42],"(SPI),":[43],"in":[46,62,142,174,263,269],"infant":[48],"formula,":[49],"with":[50,91],"those":[51,172],"17\u03b2-estradiol":[53],"(E2),":[54],"global":[56],"gene":[57],"expression":[58,107,124,160],"profiles":[59],"morphology":[61],"female":[64],"rat":[65,265],"mammary":[66,266],"gland.":[67],"Rats":[68,82],"were":[69,83],"fed":[70],"AIN-93G":[71],"diets":[72],"containing":[73],"casein":[74],"or":[75,95,113,131,148],"SPI":[76,121,155,215,230,243,258],"beginning":[77],"postnatal":[79,86],"d":[80,87],"30.":[81],"ovariectomized":[84],"50":[88],"treated":[90],"5":[92],"\u03bcg/kg/d":[93],"E2":[94,104,158,166,213,241],"vehicle":[96],"for":[97,216,222],"14":[98],"d.":[99],"Microarray":[100],"analysis":[101],"revealed":[102],"that":[103,257],"treatment":[105],"altered":[106,123,159],"780":[109],"genes":[110,128,141,163],"more":[111,129,146],"than":[112,130,147],"equal":[114,132,149],"2-fold":[116],"(P":[117,227,251],"<":[118,228,252],"0.05),":[119],"whereas":[120],"feeding":[122,156],"only":[126,139,260],"53":[127],"2-fold.":[134,151],"Moreover,":[135],"groups":[137],"had":[138],"10":[140],"common":[143],"increase":[145],"The":[152],"combination":[153,211],"422":[162],"reversed":[165],"many":[169],"mRNAs,":[170],"including":[171],"involved":[173],"c-myc":[176],"signaling":[177],"pathway,":[178],"cyclin":[179],"D1,":[180],"Ki67.":[182],"ER\u03b1":[183],"binding":[184,206],"its":[186],"response":[187],"element":[188],"Tie-2/Tek":[191,218],"progesterone":[193,224],"receptor":[194,225],"promoters":[195],"was":[196,207],"increased":[197,221],"by":[198,209],"E2,":[199],"but":[200,220],"not":[201],"SPI,":[202],"this":[204],"promoter":[205,219,226],"suppressed":[208],"+":[214,242],"0.05).":[229,253],"reduced":[231,244],"ratio":[233],"epithelial":[235,246],"fat":[237,248],"pad":[238,249],"area":[239,250],"These":[254],"data":[255],"suggest":[256],"is":[259],"minimally":[261],"estrogenic":[262],"gland":[267],"even":[268],"absence":[271],"endogenous":[273],"estrogens.":[274]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}