{"id":"https://openalex.org/W1980720468","doi":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","title":"Population pharmacokinetics of lopinavir in combination with ritonavir in HIV\u20101\u2010infected patients","display_name":"Population pharmacokinetics of lopinavir in combination with ritonavir in HIV\u20101\u2010infected patients","publication_year":2005,"publication_date":"2005-07-19","ids":{"openalex":"https://openalex.org/W1980720468","doi":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","mag":"1980720468","pmid":"https://pubmed.ncbi.nlm.nih.gov/16187970","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884825"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.2005.02455.x","doi":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2005.02455.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2005.02455.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034884716","display_name":"Kristel M. L. Crommentuyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"K. M. L. Crommentuyn","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, Slotervaart Hospital, 1066 EC Amsterdam, the Netherlands. Apkcr@slz.nl","Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, Slotervaart Hospital, 1066 EC Amsterdam, the Netherlands. Apkcr@slz.nl","institution_ids":["https://openalex.org/I2802065108"]},{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070794861","display_name":"Bregt S Kappelhoff","orcid":"https://orcid.org/0009-0006-9397-450X","observed_orcids":["https://orcid.org/0009-0006-9397-450X"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B. S. Kappelhoff","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102945216","display_name":"Jan Willem Mulder","orcid":"https://orcid.org/0000-0002-9768-3797","observed_orcids":["https://orcid.org/0000-0002-9768-3797"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. W. Mulder","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113567196","display_name":"Albert T.A. Mairuhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. T. A. Mairuhu","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113456514","display_name":"E.C.M. van Gorp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. C. M. Van Gorp","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109900774","display_name":"P. L. Meenhorst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. L. Meenhorst","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam and","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010531755","display_name":"Alwin D. R. Huitema","orcid":"https://orcid.org/0000-0003-1939-4639","observed_orcids":["https://orcid.org/0000-0003-1939-4639"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. D. R. Huitema","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,","institution_ids":["https://openalex.org/I2802065108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. H. Beijnen","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,","Faculty of Pharmaceutical Sciences, Department of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, PO Box 80.082, 3508 TB Utrecht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam,","institution_ids":["https://openalex.org/I2802065108"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Department of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, PO Box 80.082, 3508 TB Utrecht, the Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034884716"],"corresponding_institution_ids":["https://openalex.org/I2802065108"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.2378,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.91079127,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"60","issue":"4","first_page":"378","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lopinavir","display_name":"lopinavir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":1.0},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.8190000057220459},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ritonavir-boosting","display_name":"ritonavir boosting","score":0.722000002861023},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":1.0},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7570000290870667},{"id":"https://openalex.org/keywords/absorption-rate-constant","display_name":"absorption rate constant","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2777182164","wikidata":"https://www.wikidata.org/wiki/Q422585","display_name":"Lopinavir","level":5,"score":0.9461296200752258},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.9002560377120972},{"id":"https://openalex.org/C2781392899","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Lopinavir/ritonavir","level":5,"score":0.86204594373703},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.780213475227356},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.5938229560852051},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5711210370063782},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5355574488639832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44885915517807007},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.4276224374771118},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.421514630317688},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.19931349158287048},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.19255909323692322},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.18639543652534485},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.13474220037460327},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.110088050365448},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0677051842212677},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.2005.02455.x","doi":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2005.02455.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1884825","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884825","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:16187970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16187970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.2005.02455.x","doi":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2005.02455.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2005.02455.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980720468.pdf","grobid_xml":"https://content.openalex.org/works/W1980720468.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W232553080","https://openalex.org/W970450957","https://openalex.org/W1501302493","https://openalex.org/W1847561584","https://openalex.org/W1864203502","https://openalex.org/W1930642263","https://openalex.org/W1968735362","https://openalex.org/W1993340775","https://openalex.org/W1998616088","https://openalex.org/W1998690882","https://openalex.org/W2002977614","https://openalex.org/W2003623971","https://openalex.org/W2014053790","https://openalex.org/W2021775978","https://openalex.org/W2034618224","https://openalex.org/W2047120948","https://openalex.org/W2054695085","https://openalex.org/W2059185356","https://openalex.org/W2066464642","https://openalex.org/W2068946470","https://openalex.org/W2106171109","https://openalex.org/W2108013853","https://openalex.org/W2111376288","https://openalex.org/W2112710992","https://openalex.org/W2112857740","https://openalex.org/W2117312836","https://openalex.org/W2120128540","https://openalex.org/W2141791066","https://openalex.org/W2161446377","https://openalex.org/W2400426333","https://openalex.org/W2769597679","https://openalex.org/W3126246200","https://openalex.org/W3191913224","https://openalex.org/W4239194041","https://openalex.org/W4251758068"],"related_works":["https://openalex.org/W2079159082","https://openalex.org/W2170081257","https://openalex.org/W56813580","https://openalex.org/W2036267503","https://openalex.org/W3092531092","https://openalex.org/W2606012441","https://openalex.org/W2022289827","https://openalex.org/W2047120948","https://openalex.org/W1604494817","https://openalex.org/W1991379107"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"develop":[2],"a":[3,56,107,117,156,176,220,225],"population":[4],"pharmacokinetic":[5,66,246],"model":[6,59,71,127,154,221],"for":[7,72,97,159,248],"lopinavir":[8,37,79,89,163,210],"in":[9,13,23,38,182],"combination":[10,39],"with":[11,40,80,190],"ritonavir,":[12],"which":[14,24,173,205],"the":[15,73,76,102,112,120,160,183,194,207,230,235,245,249,254,260],"interaction":[16,100],"between":[17,26,101,111,229],"both":[18],"drugs":[19,103],"was":[20,82,104,196],"characterized,":[21],"and":[22,29,90,119,132,145,234,239,257],"relationships":[25],"patient":[27],"characteristics":[28],"pharmacokinetics":[30,35,77,195],"were":[31,42,53,95,136],"identified.":[32],"METHODS:":[33],"The":[34,99,126,153,187],"of":[36,65,75,78,124,130,162,166,178,185,199,209,237,244,253,262],"ritonavir":[41,51,81,92,115,165,233],"described":[43,105],"using":[44],"NONMEM":[45],"(version":[46],"V,":[47],"level":[48],"1.1).":[49],"First,":[50],"data":[52],"fitted":[54],"to":[55,60,114,175,232],"previously":[57],"developed":[58,219],"obtain":[61],"individual":[62],"Bayesian":[63],"estimates":[64],"parameters.":[67],"Hereafter,":[68],"an":[69,241],"integrated":[70],"description":[74,243],"designed.":[83],"RESULTS:":[84],"From":[85],"122":[86],"outpatients":[87],"748":[88,91],"plasma":[93],"concentrations":[94],"available":[96],"analysis.":[98],"by":[106,211],"time-independent":[108,226],"inverse":[109,227],"relationship":[110,228],"exposure":[113,231],"over":[116],"dosing-interval":[118],"apparent":[121],"clearance":[122],"(CL/F)":[123],"lopinavir.":[125,263],"parameters":[128,247],"volume":[129],"distribution":[131],"absorption":[133],"rate":[134],"constant":[135],"61.6":[137],"l":[138,168,180],"(95%":[139,148],"prediction":[140],"interval":[141],"(PI)":[142],"22.4,":[143],"83.7)":[144],"0.564":[146],"h(-1)":[147,169,181],"PI":[149],"0.208,":[150],"0.947),":[151],"respectively.":[152],"yielded":[155],"theoretical":[157],"value":[158,177],"CL/F":[161,208,236,261],"without":[164],"14.8":[167],"(95%PI":[170],"12.1,":[171],"20.1),":[172],"translates":[174],"5.73":[179],"presence":[184],"ritonavir.":[186],"only":[188],"factor":[189],"significant":[191],"effect":[192],"on":[193],"concurrent":[197],"use":[198,252],"non-nucleoside":[200],"reverse":[201],"transcriptase":[202],"inhibitors":[203],"(NNRTI),":[204],"increased":[206,259],"39%":[212],"(P":[213],"<":[214],"0.001).":[215],"CONCLUSIONS:":[216],"We":[217],"have":[218],"that":[222],"has":[223],"defined":[224],"lopinavir,":[238],"provided":[240],"adequate":[242],"latter.":[250],"Concomitant":[251],"NNRTIs":[255],"efavirenz":[256],"nevirapine":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}