{"id":"https://openalex.org/W1980693221","doi":"https://doi.org/10.1002/cncr.23076","title":"Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression","display_name":"Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression","publication_year":2007,"publication_date":"2007-10-11","ids":{"openalex":"https://openalex.org/W1980693221","doi":"https://doi.org/10.1002/cncr.23076","mag":"1980693221","pmid":"https://pubmed.ncbi.nlm.nih.gov/17932890"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.23076","doi":"https://doi.org/10.1002/cncr.23076","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.23076","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012800731","display_name":"Janine G. Einspahr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janine G. Einspahr","raw_affiliation_strings":["Department of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA. jeinspahr@azcc.arizona.edu","Arizona Cancer Center, University of Arizona, Tucson, Arizona","Department of Medicine, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA. jeinspahr@azcc.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103507455","display_name":"Tracy Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy L. Thomas","raw_affiliation_strings":["Department of Dermatology, University of New Mexico, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of New Mexico, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053609519","display_name":"Kathylynn Saboda","orcid":"https://orcid.org/0000-0003-2784-1670","observed_orcids":["https://orcid.org/0000-0003-2784-1670"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathylynn Saboda","raw_affiliation_strings":["Arizona Cancer Center, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023492677","display_name":"Brian J. Nickolof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4405255059","display_name":"University of New Mexico Health Sciences Center","ror":"https://ror.org/02jvjmd55","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Nickolof","raw_affiliation_strings":["Department of Dermatology, University of New Mexico, Albuquerque, New Mexico","Department of Pathology, the Cardinal Bernardin Cancer Center, Loyola University of Chicago Medical Center, Maywood, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of New Mexico, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973","https://openalex.org/I4405255059"]},{"raw_affiliation_string":"Department of Pathology, the Cardinal Bernardin Cancer Center, Loyola University of Chicago Medical Center, Maywood, Illinois","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066095968","display_name":"James A. Warneke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Warneke","raw_affiliation_strings":["Department of Medicine, University of Arizona, Tucson, Arizona","Department of Surgery, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Surgery, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013049371","display_name":"Clara N. Curiel\u2010Lewandrowski","orcid":"https://orcid.org/0000-0001-8982-6252","observed_orcids":["https://orcid.org/0000-0001-8982-6252"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Curiel\u2010Lewandrowski","raw_affiliation_strings":["Department of Dermatology, University of Arizona, Tucson, Arizona","Department of Medicine, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067090865","display_name":"James Ranger\u2010Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Ranger\u2010Moore","raw_affiliation_strings":["Arizona Cancer Center, University of Arizona, Tucson, Arizona","Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005489179","display_name":"Laura D. Duckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Duckett","raw_affiliation_strings":["Arizona Cancer Center, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089907707","display_name":"Jerry L. Bangert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Bangert","raw_affiliation_strings":["Department of Medicine, Chao Family Comprehensive Cancer Center, Catalina Skin Institute, Tucson, Arizona","University of California at Irvine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Chao Family Comprehensive Cancer Center, Catalina Skin Institute, Tucson, Arizona","institution_ids":[]},{"raw_affiliation_string":"University of California at Irvine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061918246","display_name":"John P. Fruehauf","orcid":"https://orcid.org/0000-0002-9447-9440","observed_orcids":["https://orcid.org/0000-0002-9447-9440"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Fruehauf","raw_affiliation_strings":["University of California at Irvine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Irvine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109356977","display_name":"David Samuel Alberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Alberts","raw_affiliation_strings":["Arizona Cancer Center, University of Arizona, Tucson, Arizona","Department of Medicine, University of Arizona, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arizona Cancer Center, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Medicine, University of Arizona, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012800731"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.9854,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.85196782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"110","issue":"11","first_page":"2519","last_page":"2527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.25,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.9769999980926514},{"id":"https://openalex.org/keywords/benign-nevi","display_name":"benign nevi","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.8240000009536743},{"id":"https://openalex.org/keywords/melanoma-progression","display_name":"melanoma progression","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.9779999852180481},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.7929999828338623},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8315706253051758},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7788499593734741},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7731906175613403},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.6712683439254761},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5702590942382812},{"id":"https://openalex.org/C2776294769","wikidata":"https://www.wikidata.org/wiki/Q377568","display_name":"Melanocytic nevus","level":4,"score":0.5442076921463013},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5377336740493774},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5256460905075073},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.46127012372016907},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.42999354004859924},{"id":"https://openalex.org/C2779323059","wikidata":"https://www.wikidata.org/wiki/Q692077","display_name":"Nevus","level":3,"score":0.39997023344039917},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26359495520591736},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.2100594937801361}],"mesh":[{"descriptor_ui":"D004416","descriptor_name":"Dysplastic Nevus Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009506","descriptor_name":"Nevus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.23076","doi":"https://doi.org/10.1002/cncr.23076","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.23076","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:17932890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17932890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2159449340","display_name":null,"funder_award_id":"CA 23074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G482860941","display_name":null,"funder_award_id":"CA 27502","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7709471183","display_name":"Chemoprevention of Skin Cancer Program Project","funder_award_id":"P01CA027502","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909272","display_name":"University of Arizona Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W65259777","https://openalex.org/W86774168","https://openalex.org/W122317830","https://openalex.org/W125016941","https://openalex.org/W137204540","https://openalex.org/W171437669","https://openalex.org/W1546101705","https://openalex.org/W1617231590","https://openalex.org/W1965734230","https://openalex.org/W1969662781","https://openalex.org/W1969908659","https://openalex.org/W1972100810","https://openalex.org/W1975813183","https://openalex.org/W1978233722","https://openalex.org/W1979139036","https://openalex.org/W1982787753","https://openalex.org/W1986402525","https://openalex.org/W1990681500","https://openalex.org/W1992515309","https://openalex.org/W1994571309","https://openalex.org/W2004913529","https://openalex.org/W2006410648","https://openalex.org/W2008831582","https://openalex.org/W2009081283","https://openalex.org/W2009831880","https://openalex.org/W2010397777","https://openalex.org/W2010927639","https://openalex.org/W2016646322","https://openalex.org/W2020109267","https://openalex.org/W2031467322","https://openalex.org/W2034218449","https://openalex.org/W2037244915","https://openalex.org/W2041488117","https://openalex.org/W2042616935","https://openalex.org/W2043315819","https://openalex.org/W2050152316","https://openalex.org/W2051421411","https://openalex.org/W2055656744","https://openalex.org/W2055905515","https://openalex.org/W2055987653","https://openalex.org/W2056669173","https://openalex.org/W2064215096","https://openalex.org/W2069475288","https://openalex.org/W2074283639","https://openalex.org/W2089149411","https://openalex.org/W2095038799","https://openalex.org/W2123060447","https://openalex.org/W2131365547","https://openalex.org/W2133820317","https://openalex.org/W2134687017","https://openalex.org/W2141046053","https://openalex.org/W2142528392","https://openalex.org/W2149170850","https://openalex.org/W2152606604","https://openalex.org/W2158294624","https://openalex.org/W2158965678","https://openalex.org/W2160916229","https://openalex.org/W2169351903","https://openalex.org/W2188864596","https://openalex.org/W2314811237","https://openalex.org/W2321802999","https://openalex.org/W2335014389","https://openalex.org/W2412365924","https://openalex.org/W2413287713","https://openalex.org/W2413513425","https://openalex.org/W2444256172","https://openalex.org/W2463951386","https://openalex.org/W2485127851","https://openalex.org/W2808598014","https://openalex.org/W4210963749","https://openalex.org/W4211038110","https://openalex.org/W4242231501","https://openalex.org/W4322701229"],"related_works":["https://openalex.org/W2413287713","https://openalex.org/W2031467322","https://openalex.org/W2891930795","https://openalex.org/W1979139036","https://openalex.org/W2050364391","https://openalex.org/W2890537713","https://openalex.org/W2363447442","https://openalex.org/W2069475288","https://openalex.org/W2412461955","https://openalex.org/W2463951386"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,65],"considerable":[2],"body":[3],"of":[4,13,37,42,54,59,92,204,219,222],"evidence":[5],"supports":[6],"the":[7,60,189,211,215,220],"concept":[8],"that":[9,56,193],"a":[10,19,31,89,151,186,201],"significant":[11],"number":[12],"cutaneous":[14],"malignant":[15],"melanomas":[16,95,171],"progress":[17],"through":[18],"precursor":[20],"lesion":[21],"or":[22,114,180],"dysplastic":[23],"melanocytic":[24,107,208],"nevi":[25,79],"(DN).":[26],"Tumor":[27],"angiogenesis":[28,43,55],"likely":[29],"plays":[30],"critical":[32],"role":[33],"in":[34,74,88,106,116,121,132,197,207],"early":[35],"development":[36],"melanoma,":[38],"and":[39,49,67,81,87,99,129,160,217],"intermediate":[40],"biomarkers":[41],"could":[44],"be":[45,200],"useful":[46],"as":[47],"chemoprevention":[48],"prognostic":[50],"markers.":[51],"METHODS:":[52],"Markers":[53],"included":[57],"expression":[58,105,196],"vascular":[61],"endothelial":[62],"growth":[63],"factor":[64],"(VEGF-A)":[66],"microvessel":[68],"density":[69],"counts":[70],"(MVD)":[71],"were":[72,172],"evaluated":[73],"13":[75],"prospectively":[76],"collected":[77],"benign":[78],"(BN)":[80],"19":[82],"DN":[83,122,140,161,181,198,223],"from":[84],"16":[85],"individuals":[86],"comparison":[90],"group":[91],"17":[93],"primary":[94,133,170],"(16":[96],"archival":[97],"samples":[98],"1":[100],"prospective":[101,187],"melanoma).":[102,142,183],"RESULTS:":[103],"VEGF":[104],"cells":[108],"(mean+/-standard":[109],"error":[110],"[SE])":[111],"was":[112],"low":[113],"absent":[115],"BN":[117,126,157,166,179],"(3.4+/-1.4),":[118],"increased":[119,130,194],"significantly":[120,173],"(41.0+/-10.1;":[123],"P=.0003":[124],"for":[125,139,165,178,213],"vs":[127,141,167,182],"DN),":[128,168],"further":[131],"melanoma":[134],"(119.9+/-28.3;":[135],"P":[136],"=":[137],".06":[138],"MVD":[143],"using":[144],"CD31":[145],"(mean+/-SE":[146],"[percentage":[147],"x":[148],"intensity])":[149],"followed":[150],"similar":[152],"pattern":[153],"with":[154,210],"similarity":[155],"between":[156],"(2.6+/-0.7;":[158],"N=13)":[159],"(2.2+/-0.8;":[162],"N=19;":[163],"P=.4":[164],"whereas":[169],"higher":[174],"(39.4+/-6.4;":[175],"N=17;":[176],"P=.0001":[177],"CONCLUSIONS:":[184],"In":[185],"setting,":[188],"current":[190],"data":[191],"suggested":[192],"VEGF-A":[195],"may":[199],"good":[202],"indicator":[203],"preneoplastic":[205],"change":[206],"lesions":[209],"potential":[212],"improving":[214],"understanding":[216],"prevention":[218],"transformation":[221],"to":[224],"melanoma.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}