{"id":"https://openalex.org/W1980683029","doi":"https://doi.org/10.1016/j.ijpharm.2010.08.006","title":"A statistical approach to the development of a transdermal delivery system for ondansetron","display_name":"A statistical approach to the development of a transdermal delivery system for ondansetron","publication_year":2010,"publication_date":"2010-08-11","ids":{"openalex":"https://openalex.org/W1980683029","doi":"https://doi.org/10.1016/j.ijpharm.2010.08.006","mag":"1980683029","pmid":"https://pubmed.ncbi.nlm.nih.gov/20705125"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijpharm.2010.08.006","doi":"https://doi.org/10.1016/j.ijpharm.2010.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2010.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024394826","display_name":"Yasuko Obata","orcid":"https://orcid.org/0000-0001-6759-207X","observed_orcids":["https://orcid.org/0000-0001-6759-207X"]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuko Obata","raw_affiliation_strings":["Department of Pharmaceutics, Hoshi University, Tokyo, Japan. obata@hoshi.ac.jp","Department of Pharmaceutics, Hoshi University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Hoshi University, Tokyo, Japan. obata@hoshi.ac.jp","institution_ids":["https://openalex.org/I36296616"]},{"raw_affiliation_string":"Department of Pharmaceutics, Hoshi University, Tokyo, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003279548","display_name":"Yuriko Ashitaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuriko Ashitaka","raw_affiliation_strings":["Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shingo Kikuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Kikuchi","raw_affiliation_strings":["Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020539331","display_name":"Koichi Isowa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichi Isowa","raw_affiliation_strings":["The Center of Japan Biological Chemistry Co. Ltd., 52 Fukue, Kaizu-cho, Kaizu, Gifu 503-0628, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center of Japan Biological Chemistry Co. Ltd., 52 Fukue, Kaizu-cho, Kaizu, Gifu 503-0628, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100852349","display_name":"Kozo Takayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozo Takayama","raw_affiliation_strings":["Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024394826"],"corresponding_institution_ids":["https://openalex.org/I36296616"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.4583,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87074919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"399","issue":"1-2","first_page":"87","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.8799999952316284},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":0.9210000038146973},{"id":"https://openalex.org/keywords/l-menthol","display_name":"L-menthol","score":0.7680000066757202},{"id":"https://openalex.org/keywords/penetration-enhancers","display_name":"penetration enhancers","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hydroxyethyl-cellulose","display_name":"hydroxyethyl cellulose","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hydroxypropyl-cellulose","display_name":"hydroxypropyl cellulose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isopropanol","display_name":"isopropanol","score":0.8270000219345093},{"id":"https://openalex.org/keywords/n-methyl-2-pyrrolidone","display_name":"N-methyl-2-pyrrolidone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/thin-plate-spline-interpolation","display_name":"thin-plate spline interpolation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pharmacological-activity","display_name":"pharmacological activity","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8798760175704956},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.8090900182723999},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.6906149387359619},{"id":"https://openalex.org/C2780194911","wikidata":"https://www.wikidata.org/wiki/Q407418","display_name":"Menthol","level":2,"score":0.6653355956077576},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.5736466646194458},{"id":"https://openalex.org/C2777170512","wikidata":"https://www.wikidata.org/wiki/Q410011","display_name":"Ondansetron","level":3,"score":0.5551213026046753},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5539777874946594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5319023132324219},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.48474571108818054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4846828281879425},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4574834704399109},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4336870312690735},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3755861520767212},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.19892749190330505},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.18470776081085205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17765921354293823},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12335821986198425},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09100538492202759},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06493544578552246},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.05845379829406738},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000932","descriptor_name":"Antiemetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008812","descriptor_name":"Mice, Hairless","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023422","descriptor_name":"Skin Irritancy Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijpharm.2010.08.006","doi":"https://doi.org/10.1016/j.ijpharm.2010.08.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijpharm.2010.08.006","pdf_url":null,"source":{"id":"https://openalex.org/S131016564","display_name":"International Journal of Pharmaceutics","issn_l":"0378-5173","issn":["0378-5173","1873-3476"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:20705125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20705125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pharmaceutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W110251752","https://openalex.org/W579662085","https://openalex.org/W1966829527","https://openalex.org/W1985109147","https://openalex.org/W1986774418","https://openalex.org/W1990478616","https://openalex.org/W2008424294","https://openalex.org/W2017889321","https://openalex.org/W2021781189","https://openalex.org/W2034030708","https://openalex.org/W2037064517","https://openalex.org/W2037102194","https://openalex.org/W2050391908","https://openalex.org/W2058201576","https://openalex.org/W2064805272","https://openalex.org/W2073457923","https://openalex.org/W2073531403","https://openalex.org/W2090572919","https://openalex.org/W2092378439","https://openalex.org/W2096268542","https://openalex.org/W2129492476","https://openalex.org/W2141824701","https://openalex.org/W2313837188","https://openalex.org/W2326428613","https://openalex.org/W2397924113","https://openalex.org/W2772887788"],"related_works":["https://openalex.org/W1525279745","https://openalex.org/W2045638409","https://openalex.org/W2994052982","https://openalex.org/W2060933570","https://openalex.org/W2169961366","https://openalex.org/W2076954754","https://openalex.org/W6931595383","https://openalex.org/W2163878864","https://openalex.org/W3214681976","https://openalex.org/W4391781054"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}