{"id":"https://openalex.org/W1980682199","doi":"https://doi.org/10.1126/science.1243884","title":"T H 17 Cell Differentiation Is Regulated by the Circadian Clock","display_name":"T H 17 Cell Differentiation Is Regulated by the Circadian Clock","publication_year":2013,"publication_date":"2013-11-07","ids":{"openalex":"https://openalex.org/W1980682199","doi":"https://doi.org/10.1126/science.1243884","mag":"1980682199","pmid":"https://pubmed.ncbi.nlm.nih.gov/24202171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165400"},"language":"en","primary_location":{"id":"doi:10.1126/science.1243884","doi":"https://doi.org/10.1126/science.1243884","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1243884","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165400","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065527113","display_name":"Xiaofei Yu","orcid":"https://orcid.org/0000-0002-1712-331X","observed_orcids":["https://orcid.org/0000-0002-1712-331X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofei Yu","raw_affiliation_strings":["Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042823368","display_name":"Darcy Rollins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darcy Rollins","raw_affiliation_strings":["Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077036049","display_name":"Kelly A. Ruhn","orcid":"https://orcid.org/0000-0002-9440-8546","observed_orcids":["https://orcid.org/0000-0002-9440-8546"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Ruhn","raw_affiliation_strings":["Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053396007","display_name":"Jeremy J. Stubblefield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy J. Stubblefield","raw_affiliation_strings":["Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015774135","display_name":"Carla B. Green","orcid":"https://orcid.org/0000-0002-3947-5156","observed_orcids":["https://orcid.org/0000-0002-3947-5156"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla B. Green","raw_affiliation_strings":["Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066241229","display_name":"Masaki Kashiwada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Kashiwada","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004527964","display_name":"Paul B. Rothman","orcid":"https://orcid.org/0000-0002-7484-1326","observed_orcids":["https://orcid.org/0000-0002-7484-1326"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul B. Rothman","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076767575","display_name":"Joseph S. Takahashi","orcid":"https://orcid.org/0000-0003-0384-8878","observed_orcids":["https://orcid.org/0000-0003-0384-8878"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S. Takahashi","raw_affiliation_strings":["Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049357046","display_name":"Lora V. Hooper","orcid":"https://orcid.org/0000-0002-2759-4641","observed_orcids":["https://orcid.org/0000-0002-2759-4641"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lora V. Hooper","raw_affiliation_strings":["Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049357046"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":12.9471,"has_fulltext":false,"cited_by_count":460,"citation_normalized_percentile":{"value":0.99335708,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"342","issue":"6159","first_page":"727","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nfil3","display_name":"NFIL3","score":0.8790000081062317},{"id":"https://openalex.org/keywords/rorgammat","display_name":"ROR\u03b3t","score":0.9200000166893005},{"id":"https://openalex.org/keywords/rev-erbalpha","display_name":"NR1D1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.5170000195503235},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.6620000004768372},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6880000233650208},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8301501274108887},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6514997482299805},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6430487036705017},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.62394118309021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5871201157569885},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5807099342346191},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5352925062179565},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48148858547210693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47586601972579956},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4089271128177643},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10278457403182983}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005856","descriptor_name":"Germ-Free Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056953","descriptor_name":"Nuclear Receptor Subfamily 1, Group D, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056953","descriptor_name":"Nuclear Receptor Subfamily 1, Group D, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057132","descriptor_name":"Nuclear Receptor Subfamily 1, Group F, Member 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.1243884","doi":"https://doi.org/10.1126/science.1243884","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1243884","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:24202171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24202171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3134789","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4165400","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4165400/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.882.6893","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.882.6893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://science.sciencemag.org/content/sci/342/6159/727.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3134789","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165400","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8489710956","display_name":"Study on roles of circadian clock gene in allergic immune response","funder_award_id":"24590088","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000915388","display_name":"Microbial Regulation of Retinol Transport and its Role in Intestinal Immunity","funder_award_id":"R01DK070855","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1981920912","https://openalex.org/W1991098988","https://openalex.org/W1992494470","https://openalex.org/W1996021680","https://openalex.org/W2004774344","https://openalex.org/W2008546111","https://openalex.org/W2010104326","https://openalex.org/W2010247691","https://openalex.org/W2011848880","https://openalex.org/W2019460213","https://openalex.org/W2021340905","https://openalex.org/W2024490058","https://openalex.org/W2027980220","https://openalex.org/W2054513544","https://openalex.org/W2057792168","https://openalex.org/W2069677284","https://openalex.org/W2077483301","https://openalex.org/W2091531174","https://openalex.org/W2091912666","https://openalex.org/W2102039847","https://openalex.org/W2104290916","https://openalex.org/W2107369528","https://openalex.org/W2118201373","https://openalex.org/W2121472070","https://openalex.org/W2126740537","https://openalex.org/W2132434008","https://openalex.org/W2142017607","https://openalex.org/W2143625465","https://openalex.org/W2164824098","https://openalex.org/W2166839330"],"related_works":["https://openalex.org/W4313355080","https://openalex.org/W2001231369","https://openalex.org/W1409616561","https://openalex.org/W2978364603","https://openalex.org/W7141160579","https://openalex.org/W4206413506","https://openalex.org/W7083322447","https://openalex.org/W4214820140","https://openalex.org/W4313386018","https://openalex.org/W2624807061"],"abstract_inverted_index":{"Circadian":[0],"clocks":[1],"regulate":[2],"numerous":[3],"physiological":[4],"processes":[5],"that":[6,38,61],"vary":[7],"across":[8],"the":[9,17,21,54,62,75,84,89],"day-night":[10],"(diurnal)":[11],"cycle,":[12],"but":[13],"if":[14],"and":[15,42,73,99,112],"how":[16],"circadian":[18,85,129],"clock":[19,86],"regulates":[20],"adaptive":[22],"immune":[23,36,124],"system":[24],"is":[25,51,100,126],"mostly":[26],"unclear.":[27],"Interleukin-17-producing":[28],"CD4(+)":[29],"T":[30],"helper":[31],"(T(H)17)":[32],"cells":[33,37],"are":[34],"proinflammatory":[35],"protect":[39],"against":[40],"bacterial":[41],"fungal":[43],"infections":[44],"at":[45],"mucosal":[46],"surfaces.":[47],"Their":[48],"lineage":[49,95,119],"specification":[50,96,120],"regulated":[52],"by":[53,70],"orphan":[55],"nuclear":[56],"receptor":[57],"ROR\u03b3t.":[58],"We":[59],"show":[60],"transcription":[63,90],"factor":[64,91],"NFIL3":[65,78],"suppresses":[66],"T(H)17":[67,80,109],"cell":[68,81,110,125],"development":[69,82],"directly":[71],"binding":[72],"repressing":[74],"Ror\u03b3t":[76],"promoter.":[77],"links":[79],"to":[83,115],"network":[87],"through":[88],"REV-ERB\u03b1.":[92],"Accordingly,":[93],"TH17":[94],"varies":[97],"diurnally":[98],"altered":[101],"in":[102],"Rev-erb\u03b1(-/-)":[103],"mice.":[104],"Light-cycle":[105],"disruption":[106],"elevated":[107],"intestinal":[108],"frequencies":[111],"increased":[113],"susceptibility":[114],"inflammatory":[116],"disease.":[117],"Thus,":[118],"of":[121],"a":[122],"key":[123],"under":[127],"direct":[128],"control.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":42},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
