{"id":"https://openalex.org/W1980616359","doi":"https://doi.org/10.1254/jphs.fmj04001x5","title":"Proof of the Mysterious Efficacy of Ginseng: Basic and Clinical Trials: Clinical Effects of Medical Ginseng, Korean Red Ginseng: Specifically, Its Anti-stress Action for Prevention of Disease","display_name":"Proof of the Mysterious Efficacy of Ginseng: Basic and Clinical Trials: Clinical Effects of Medical Ginseng, Korean Red Ginseng: Specifically, Its Anti-stress Action for Prevention of Disease","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1980616359","doi":"https://doi.org/10.1254/jphs.fmj04001x5","mag":"1980616359","pmid":"https://pubmed.ncbi.nlm.nih.gov/15215639"},"language":"en","primary_location":{"id":"doi:10.1254/jphs.fmj04001x5","doi":"https://doi.org/10.1254/jphs.fmj04001x5","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fmj04001x5","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/95/2/95_2_158/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jphs/95/2/95_2_158/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hitoshi Kaneko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hitoshi Kaneko","raw_affiliation_strings":["Kaneko Heart Clinic, Matsuyama, Japan. khc316@gamma.ocn.ne.jp","Kaneko Heart Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaneko Heart Clinic, Matsuyama, Japan. khc316@gamma.ocn.ne.jp","institution_ids":[]},{"raw_affiliation_string":"Kaneko Heart Clinic","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015517523","display_name":"Kozo Nakanishi","orcid":"https://orcid.org/0000-0003-1911-342X","observed_orcids":["https://orcid.org/0000-0003-1911-342X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kozo Nakanishi","raw_affiliation_strings":["Nakanishi Clinic of Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nakanishi Clinic of Internal Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":null,"fwci":1.7687,"has_fulltext":true,"cited_by_count":148,"citation_normalized_percentile":{"value":0.81690405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"95","issue":"2","first_page":"158","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/korean-red-ginseng","display_name":"Korean red ginseng","score":0.8960000276565552},{"id":"https://openalex.org/keywords/panax-ginseng","display_name":"Panax ginseng","score":0.8669999837875366},{"id":"https://openalex.org/keywords/anti-stress-effect","display_name":"anti-stress effects","score":0.8519999980926514},{"id":"https://openalex.org/keywords/homeostasis","display_name":"homeostasis","score":0.718999981880188},{"id":"https://openalex.org/keywords/psychosomatic-disorders","display_name":"psychosomatic disorders","score":0.7379999756813049},{"id":"https://openalex.org/keywords/kampo-medicine","display_name":"Kampo medicine","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.6029999852180481},{"id":"https://openalex.org/keywords/common-cold","display_name":"common cold","score":0.7829999923706055},{"id":"https://openalex.org/keywords/influenza-prevention","display_name":"influenza prevention","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.9351462125778198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6785154342651367},{"id":"https://openalex.org/C2779626144","wikidata":"https://www.wikidata.org/wiki/Q403356","display_name":"Kampo","level":3,"score":0.6704409718513489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6396902799606323},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5452743768692017},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5296532511711121},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4912518858909607},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3754638135433197},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.23382627964019775},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2125169336795807},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20562002062797546},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1216571033000946}],"mesh":[{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003139","descriptor_name":"Common Cold","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005894","descriptor_name":"Panax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1254/jphs.fmj04001x5","doi":"https://doi.org/10.1254/jphs.fmj04001x5","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fmj04001x5","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/95/2/95_2_158/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:15215639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15215639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.580.1910","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.580.1910","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://plaza.umin.ac.jp/JPS1927/jps/JPS-Preprints/95-2-1-5.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a6ce01d4f8ae48f8b92385b4e53c619f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6ce01d4f8ae48f8b92385b4e53c619f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 95, Iss 2, Pp 158-162 (2004)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1254/jphs.fmj04001x5","doi":"https://doi.org/10.1254/jphs.fmj04001x5","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fmj04001x5","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/95/2/95_2_158/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980616359.pdf","grobid_xml":"https://content.openalex.org/works/W1980616359.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2343265841","https://openalex.org/W2411103601","https://openalex.org/W2412257797"],"related_works":["https://openalex.org/W2109635600","https://openalex.org/W2394823549","https://openalex.org/W1920404372","https://openalex.org/W4382515144","https://openalex.org/W3026141663","https://openalex.org/W2153182181","https://openalex.org/W2791540364","https://openalex.org/W920014149","https://openalex.org/W2240936923","https://openalex.org/W2555320794"],"abstract_inverted_index":{"We":[0,108],"are":[1],"exposed":[2,122],"to":[3,102,123],"many":[4],"external":[5],"and":[6,12,24,40,78,87,110,130],"internal":[7],"stresses":[8,125],"in":[9,21,58],"this":[10],"day":[11],"age.":[13],"Stress":[14],"weakens":[15],"the":[16,60,68,95,104,112,136,143],"function":[17],"of":[18,37,56,71,91,106,114,139],"immune":[19,85],"systems":[20],"living":[22,92,118],"organisms":[23,93,119],"disturbs":[25],"homeostasis.":[26],"As":[27],"a":[28],"result,":[29],"stress":[30,39],"induces":[31],"various":[32,124],"psychosomatic":[33],"diseases.":[34],"Thus,":[35],"ways":[36],"reducing":[38],"thus":[41],"protecting":[42],"humans":[43],"from":[44,80],"disease":[45],"must":[46],"be":[47],"developed.":[48],"One":[49],"such":[50,126],"method":[51],"is":[52,99],"called":[53],"\"the":[54],"prevention":[55],"Mibyou\"":[57],"Kampo,":[59],"Chinese":[61],"traditional":[62],"medicine.":[63],"Many":[64],"studies":[65],"have":[66],"reported":[67],"direct":[69],"effects":[70,138],"medical":[72,115,140],"ginseng":[73,116,141],"on":[74,117,142],"damaged":[75],"target":[76],"organs":[77],"recovery":[79],"disease.":[81,107],"It":[82,98],"also":[83,100],"increases":[84],"potential":[86],"may":[88],"maintain":[89],"homeostasis":[90],"through":[94],"autonomic-endocrine":[96],"systems.":[97],"thought":[101],"prevent":[103],"development":[105],"studied":[109],"considered":[111],"action":[113],"that":[120],"were":[121],"as":[127],"cold":[128,145],"environment":[129],"industrial":[131],"work.":[132],"Furthermore,":[133],"we":[134,154],"confirmed":[135],"preventive":[137],"common":[144],"symptom":[146],"complex,":[147],"including":[148],"flu,":[149],"by":[150],"clinical":[151],"observation.":[152],"Here,":[153],"report":[155],"our":[156],"experiences.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}