{"id":"https://openalex.org/W1980613381","doi":"https://doi.org/10.1074/jbc.m109.041707","title":"Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity","display_name":"Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity","publication_year":2010,"publication_date":"2010-04-28","ids":{"openalex":"https://openalex.org/W1980613381","doi":"https://doi.org/10.1074/jbc.m109.041707","mag":"1980613381","pmid":"https://pubmed.ncbi.nlm.nih.gov/20424172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898444"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.041707","doi":"https://doi.org/10.1074/jbc.m109.041707","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.041707","pdf_url":"http://www.jbc.org/article/S002192582060151X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582060151X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054938192","display_name":"Xiaonan H. Wang","orcid":"https://orcid.org/0000-0002-1023-8499","observed_orcids":["https://orcid.org/0000-0002-1023-8499"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaonan H. Wang","raw_affiliation_strings":["Renal Division, Emory University, Atlanta, Georgia 30322, USA. xwang03@emory.edu","Renal Division, Emory University, Atlanta, Georgia, 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Emory University, Atlanta, Georgia 30322, USA. xwang03@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Renal Division, Emory University, Atlanta, Georgia, 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100426731","display_name":"Liping Zhang","orcid":"https://orcid.org/0000-0001-5079-8450","observed_orcids":["https://orcid.org/0000-0001-5079-8450"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Zhang","raw_affiliation_strings":["Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078490088","display_name":"William E. Mitch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Mitch","raw_affiliation_strings":["Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059473455","display_name":"Joseph LeDoux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. LeDoux","raw_affiliation_strings":["Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102875864","display_name":"Junping Hu","orcid":"https://orcid.org/0000-0003-0539-4240","observed_orcids":["https://orcid.org/0000-0003-0539-4240","https://orcid.org/0009-0007-6095-7735"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junping Hu","raw_affiliation_strings":["Renal Division, Emory University, Atlanta, Georgia 30322,","#N#        Renal Division, Emory University, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Emory University, Atlanta, Georgia 30322,","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"#N#        Renal Division, Emory University, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100412675","display_name":"Jie Du","orcid":"https://orcid.org/0000-0003-0447-736X","observed_orcids":["https://orcid.org/0000-0003-0447-736X","https://orcid.org/0009-0001-5415-1635"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Du","raw_affiliation_strings":["Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology Division, Baylor College of Medicine, Houston, Texas 77030, and","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054938192","https://openalex.org/A5100412675"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I181547552"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.6505,"has_fulltext":true,"cited_by_count":89,"citation_normalized_percentile":{"value":0.93879967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"285","issue":"28","first_page":"21249","last_page":"21257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.5145999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.4535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/19s-proteasome","display_name":"19S proteasome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/proteasome-activity","display_name":"proteasome activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rpt2","display_name":"Rpt2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/rpt6","display_name":"Rpt6","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.6779999732971191},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8700000047683716},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.9098441004753113},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.8939214944839478},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6547149419784546},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5451565980911255},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5160991549491882},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.4938722252845764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4803841710090637},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.47792941331863403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4686673879623413},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4515886604785919},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.43732404708862305},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4135969579219818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3914107084274292},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38906586170196533},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27268359065055847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20389646291732788},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.162689208984375},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.1330287754535675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m109.041707","doi":"https://doi.org/10.1074/jbc.m109.041707","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.041707","pdf_url":"http://www.jbc.org/article/S002192582060151X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2898444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20424172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20424172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.041707","doi":"https://doi.org/10.1074/jbc.m109.041707","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.041707","pdf_url":"http://www.jbc.org/article/S002192582060151X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1305478283","display_name":"IGF I, its receptor and vascular remodeling","funder_award_id":"R01HL070762","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G151341764","display_name":"Renal Inflammation: Mechanisms and Consequences","funder_award_id":"P50DK064233","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G172668370","display_name":null,"funder_award_id":"P50-DK64233","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1765236984","display_name":null,"funder_award_id":"R37-DK-37175","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5556778031","display_name":"Protein Nutrition in Experimental Uremia","funder_award_id":"R37DK037175","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000001263","display_name":null,"funder_award_id":"R37DK37175","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G932723062","display_name":null,"funder_award_id":"R01 HL 70762","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980613381.pdf","grobid_xml":"https://content.openalex.org/works/W1980613381.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1495670272","https://openalex.org/W1527289043","https://openalex.org/W1556426431","https://openalex.org/W1804745580","https://openalex.org/W1963990800","https://openalex.org/W1971841367","https://openalex.org/W1971857747","https://openalex.org/W1973835062","https://openalex.org/W1978811843","https://openalex.org/W1988100248","https://openalex.org/W1995805772","https://openalex.org/W2002236561","https://openalex.org/W2003085654","https://openalex.org/W2005993899","https://openalex.org/W2007050986","https://openalex.org/W2008744347","https://openalex.org/W2020738975","https://openalex.org/W2033394004","https://openalex.org/W2033797333","https://openalex.org/W2050692600","https://openalex.org/W2056402897","https://openalex.org/W2058848912","https://openalex.org/W2062894160","https://openalex.org/W2063266560","https://openalex.org/W2066446604","https://openalex.org/W2067794232","https://openalex.org/W2074314807","https://openalex.org/W2081145901","https://openalex.org/W2092421259","https://openalex.org/W2099857411","https://openalex.org/W2100560936","https://openalex.org/W2102615617","https://openalex.org/W2109355862","https://openalex.org/W2113617434","https://openalex.org/W2122696263","https://openalex.org/W2134479830","https://openalex.org/W2150123812","https://openalex.org/W2154584639","https://openalex.org/W2159154670","https://openalex.org/W2159744672","https://openalex.org/W2162223351","https://openalex.org/W2167033587","https://openalex.org/W2169448756","https://openalex.org/W2170532025","https://openalex.org/W2341277428"],"related_works":["https://openalex.org/W2040225557","https://openalex.org/W2154584639","https://openalex.org/W2083269371","https://openalex.org/W7096604573","https://openalex.org/W2055190515","https://openalex.org/W2152777529","https://openalex.org/W1991248830","https://openalex.org/W3082106905","https://openalex.org/W2062894160","https://openalex.org/W2109709762"],"abstract_inverted_index":{"With":[0],"muscle":[1,16,59,171,184],"wasting,":[2],"caspase-3":[3,34,62,72,82,84,102,124,151],"activation":[4],"and":[5,65,134,138,158,196,198],"the":[6,13,49,81,96,106,143],"ubiquitin-proteasome":[7],"system":[8],"act":[9],"synergistically":[10],"to":[11,26,48,75,115,150,154],"increase":[12,122,130],"degradation":[14],"of":[15,51,98,113,136,148,156,193,200],"proteins.":[17],"Whether":[18],"proteasome":[19,36,55,68,77,109,132,144,201],"activity":[20,37,133],"is":[21,29,46,118],"also":[22],"elevated":[23],"in":[24,38,42,87,108,123,131,152,160,173,180],"response":[25],"catabolic":[27,174],"conditions":[28],"unknown.":[30],"We":[31],"find":[32],"that":[33,169,179],"increases":[35],"myotubes":[39],"but":[40],"not":[41],"myoblasts.":[43],"This":[44,94,162],"difference":[45],"related":[47],"cleavage":[50,85,97,135,192],"specific":[52],"19":[53],"S":[54],"subunits.":[56],"In":[57,70],"mouse":[58],"or":[60,90],"myotubes,":[61,116],"cleaves":[63,73],"Rpt2":[64,137,157,195],"Rpt6":[66,159,197],"increasing":[67],"activity.":[69,78,110,202],"myoblasts,":[71],"Rpt5":[74,91,149],"decrease":[76],"To":[79],"confirm":[80],"dependence,":[83],"sites":[86],"Rpt2,":[88],"Rpt6,":[89],"were":[92],"mutated.":[93],"prevented":[95],"these":[99],"subunits":[100,194],"by":[101,127],"as":[103,105],"well":[104],"changes":[107,142],"During":[111],"differentiation":[112,141],"myoblasts":[114,153],"there":[117,190],"an":[119],"obligatory,":[120],"transient":[121],"activity,":[125],"accompanied":[126],"a":[128,166,183],"corresponding":[129],"Rpt6.":[139],"Therefore,":[140],"type":[145],"from":[146],"sensitivity":[147,155],"myotubes.":[161],"novel":[163],"mechanism":[164],"identifies":[165],"feed-forward":[167],"amplification":[168],"augments":[170],"proteolysis":[172],"conditions.":[175],"Indeed,":[176],"we":[177],"found":[178],"mice":[181],"with":[182],"wasting":[185],"condition,":[186],"chronic":[187],"kidney":[188],"disease,":[189],"was":[191],"stimulation":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}